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  • Kristian Lampe (a1), Iris Pasternack (a2), Oskari Saarekas (a1), Leena Raustia (a1), Irina Cleemput (a3), Mirella Corio (a4), Gottfried Endel (a5), Katrine Frønsdal (a6), Iñaki Imaz (a7), Sarah Kleijnen (a8), Finn Kristensen (a9), Alric Rüther (a10), Sophie Werkö (a11) and Marina Cerbo (a12)...


Background: A framework for collaborative production and sharing of HTA information, the HTA Core Model, was originally developed within EUnetHTA in 2006–08. In this paper, we describe the further development of the Model to allow implementation and utilization of the Model online. The aim was to capture a generic HTA process that would allow effective use of the HTA Core Model and resulting HTA information while at the same time not interfering with HTA agencies' internal processes.

Methods: The work was coordinated by a development team in Finland, supported by an international expert group. Two pilot testing rounds were organized among EUnetHTA agencies and two extensive core HTA projects tested the tool in a real setting. The final work was also formally validated by a group of HTA agencies.

Results: The HTA Core Model Online—available at—is a web site hosting a) a tool to allow electronic utilization of the HTA Core Model and b) a database of produced HTA information. While access to the HTA information is free to all, the production features are currently available to EUnetHTA member agencies only. A policy was crafted to steer the use of the Model and produced information.

Conclusions: We have successfully enabled electronic use of the HTA Core Model and agreed on a policy for its utilization. The system is already being used in subsequent HTA projects within EUnetHTA Joint Action 2. Identified shortcomings and further needs will be addressed in subsequent development.



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1. Lampe, K, Mäkelä, M, Garrido, MV, et al. The HTA core model: A novel method for producing and reporting health technology assessments. Int J Technol Assess Health Care. 2009;25 (Suppl 2):920.
2. Liberati, A, Sheldon, TA, Banta, HD. EUR-ASSESS Project Subgroup report on methodology. Methodological guidance for the conduct of health technology assessment. Int J Technol Assess Health Care. 1997;13:186219.
3. Pasternack, I, Anttila, H, Mäkelä, M, Ikonen, T, Räsänen, P, Lampe, K, et al. Testing the HTA core model: Experiences from two pilot projects. Int J Technol Assess Health Care. 2009;25 (Suppl 2):2127.
4. Kristensen, FB, Lampe, K, Chase, DL, et al. Practical tools and methods for health technology assessment in Europe: Structures, methodologies, and tools developed by the European Network for Health Technology Assessment, EUnetHTA. Int J Technol Assess Health Care. 2009;25 (Suppl 2):18.
5. EUnetHTA Work Package 4. HTA core model for medical and surgical interventions 1.0r. (accessed November 11, 2013).
6. EUnetHTA Work Package 4. HTA core model for diagnostic technologies 1.0r. (accessed November 11, 2013).
7. EUnetHTA Work Package 4. Core HTA on drug eluting stents. (accessed November 11, 2013).
8. EUnetHTA Work Package 4. Core HTA on MSCT Angiography. (accessed November 11, 2013).
9. Liberati, A, Altman, DG, Tetzlaff, J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. Ann Intern Med. 2009;151:W65–W94.
10. Moher, D, Hopewell, S, Schulz, KF, et al. CONSORT 2010 explanation and elaboration: Updated guidelines for reporting parallel group randomised trials. Int J Surg. 2012;10:2855. doi: 10.1016/j.ijsu.2011.10.001.
11. von Elm, E, Altman, DG, Egger, M, et al. STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies. J Clin Epidemiol. 2008;61:344349.
12. Brouwers, M, Kho, ME, Browman, GP, et al. AGREE, II: Advancing guideline development, reporting and evaluation in healthcare. Can Med Assoc J. 2010;182:E839–E842.
13. Review Manager (RevMan) [Computer program]. Version 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
14. Kidholm, K, Ekeland, AG, Jensen, LK, et al. A model for assessment of telemedicine applications: Mast. Int J Technol Assess Health Care. 2012;28:4451.
15. EUnetHTA Joint Action WP4. Policy for the HTA Core Model and core HTA information. Version 1.0. (accessed November 11, 2013).
16. Chalon PX, Kraemer P. The EUnetHTA Information Management System: Development and lessons learned. Int J Technol Assess Health Care. 2014:514--520.
17. EUnetHTA Joint Action Final Technical Report. (accessed November 11, 2013).
18. Lo Scalzo A, Vicari N, Corio M, et al. Collaborative models for the joint production of Core Health Technology Assessments: Negative and positive aspects for the joint work of different European agencies. Int J Technol Assess Health Care 2014:536--543.
19. European Network for Health Technology Assessment. EUnetHTA Stakeholder Forum. EUnetHTA. (accessed November 11, 2013).
20. EUnetHTA Work Package 4. HTA Core Model for Screening Technologies 1.0. (accessed November 11, 2013).
21. Chase, D, Rosten, C, Turner, S, Hicks, N, Milne, R. Development of a toolkit and glossary to aid in the adaptation of health technology assessment (HTA) reports for use in different contexts. Health Technol Assess. 2009;13:1142, iii.
22. Vickery, BC. Ontologies. J Inform Sci. 1997;23:277286.
23. Lumsden, J, Hall, H, Cruickshank, P. Ontology definition and construction, and epistemological adequacy for systems interoperability: A practitioner analysis. J Inform Sci. 2001;37:248255.
24. Hauptverband der österreichischen Sozialversicherungsträger. Abdominal aorta aneurysm – Cost-effectiveness analysis on introduction of organized screening in comparison to current practice in Austria. 2013. (accessed November 11, 2013).



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