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Lipids and polyunsaturated fatty acid levels in deliberate self-harm: a 10-year follow-up study

Published online by Cambridge University Press:  04 October 2016

A. T. Gallagher ,
F. Byrne ,
I. T. Murray ,
J. Lally ,
J. M. Davis ,
M. Garland ,
J. R. Hibbeln  and
B. Hallahan
A. T. Gallagher
Affiliation:
Department of Psychiatry, Clinical Science Institute, National University of Ireland Galway, Galway, Ireland
F. Byrne
Affiliation:
Department of Psychiatry, Clinical Science Institute, National University of Ireland Galway, Galway, Ireland
I. T. Murray
Affiliation:
Department of Psychiatry, Roscommon County Hospital, Roscommon, Ireland
J. Lally
Affiliation:
Department of Psychiatry, Clinical Science Institute, National University of Ireland Galway, Galway, Ireland Institute of Psychiatry, King’s College London and National Psychosis Service, South London and Maudsley NHS Foundation Trust, London, UK
J. M. Davis
Affiliation:
Department of Psychiatry, University of Illinois, Chicago, IL, USA
M. Garland
Affiliation:
Royal College of Surgeons in Ireland, St Ita’s Hospital Portrane, County Dublin, Ireland
J. R. Hibbeln
Affiliation:
Section on Nutritional Neurosciences, LMBB, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD, USA
B. Hallahan*
Affiliation:
Department of Psychiatry, Clinical Science Institute, National University of Ireland Galway, Galway, Ireland
*
*Address for correspondence: Dr B. Hallahan, MMedSci, MD, MRCPsych, Consultant Psychiatrist and Senior Lecturer in Psychiatry, Department of Psychiatry, Clinical Science Institute, National University of Ireland, Galway, Ireland. (Email: brian.hallahan@nuigalway.ie)
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Abstract

Objectives

To evaluate if n-3 polyunsaturated fatty acids (PUFAs) and lipid levels are associated with episodes of self-harm or depression over a 10-year period.

Methods

We included 40 individuals who self-harmed and 40 controls. Episodes of self-harm and depression were ascertained and levels of depression, impulsivity, suicidal ideation and plasma lipid levels measured at baseline and at 10-year follow-up.

Results

Further episode(s) of self-harm occurred in 26% of cases. Omega-3 PUFAs or lipids were not predictive of depressive or self-harm episodes. Baseline eicosapentaenoic acid levels were modestly correlated with suicidal ideation at follow-up and dihomo-γ-linolenic acid and arachidonic acid were modestly correlated with motor impulsivity at follow-up in cases.

Conclusions

Despite significant negative correlations at baseline between plasma lipids, n-3 PUFAs and psychopathology, these levels were not predictive of clinical outcome over a 10-year period. Further research however is required due to the relatively low sample size and the risk of selection bias due to loss to follow-up in this study.

Keywords

Deliberate self-harmdepressionomega-3 polyunsaturated fatty acids
Type
Original Research
Information
Irish Journal of Psychological Medicine , Volume 34 , Issue 2 , June 2017 , pp. 117 - 126
Copyright
© College of Psychiatrists of Ireland 2016 

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References

Allain, CC, Poon, LS, Chan, CS, Richmond, W, Fu, PC (1974). Enzymatic determination of total serum cholesterol. Clinical Chemistry 20, 470–475.Google Scholar
Barratt, ES (1974). Impulsiveness and aggression. In Violence and Mental disorder: Developments in Risk Assessment (ed. J. Monahan and H. J. Steadman), pp. 61–79. University of Chicago Press: Chicago.Google Scholar
Beck, AT, Herman, J, Schuyler, D (1974). Development of suicidal intent scales. In The Prediction of Suicide (ed. A. T. Beck, H. L. P. Resnick and D. J. Lettieri), pp. 45–48. Charles Press.Google Scholar
Beck, AT, Ward, CH, Mendelson, M, Mock, J, Erbaugh, J (1961). An inventory for measuring depression. Archives of General Psychiatry 4, 561–571.CrossRefGoogle ScholarPubMed
Coccaro, EF, Harvey, PD, Kupsaw-Lawrence, E, Herbert, JL, Bernstein, DP (1991). Development of neuropharmacologically based behavioural assessments of impulsive aggressive behaviour. Journal of Neuropsychiatry and Clinical Neuroscience 3, s44–s51.Google Scholar
Edwards, R, Peet, M, Shay, JD, Horrobin, D (1998). Omega-3 highly unsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients. Journal of Affective Disorders 48, 149–155.Google Scholar
Endicott, J, Tracy, K, Burt, D, Olson, E, Coccaro, EF (2002). A novel approach to assess inter-rater reliability in the use of the Overt Aggression Scale Modified. Psychiatry Research 112, 153–159.Google Scholar
Farooqui, AA, Ong, WY, Horrocks, LA, Chen, P, Farooqui, T (2007). Comparison of bio-chemical effects of statins and fish oil in the brain: the battle of the titans. Brain Research Reviews 56, 443–471.Google Scholar
Fowkes, FG, Leng, GC, Donnan, PT, Deary, IJ, Riemersma, RA, Housley, E (1992). Serum cholesterol, triglycerides, and aggression in the general population. Lancet 340, 995–998.Google Scholar
Freedenthal, S (2008). Assessing the wish to die: a 30-year review of the Suicide Intent Scale. Archives of Suicide Research 12, 277–298.CrossRefGoogle Scholar
Garland, M, Hickey, D, Corvin, A, Golden, J, Fitzpatrick, P, Cunningham, S, Walsh, N (2000). Total serum cholesterol in relation to psychological correlates in parasuicide. British Journal of Psychiatry 177, 77–83.CrossRefGoogle ScholarPubMed
Garland, MR, Hallahan, B, McNamara, M, Carney, PA, Grimes, H, Hibbeln, JR, Harkin, A, Conroy, RM (2007). Lipids and essential fatty acids in patients presenting with self-harm. British Journal of Psychiatry 190, 112–117.Google Scholar
Hakkarainen, R, Partonen, T, Haukka, J, Virtamo, J, Albanes, D, Lonnqvist, J (2004). Is low dietary intake of omega-3 fatty acids associated with depression? American Journal of Psychiatry 161, 567–569.Google Scholar
Hallahan, B, Hibbeln, JR, Davis, JM, Garland, MR (2007). Omega-3 fatty acid supplementation in patients with recurrent self-harm. British Journal of Psychiatry 190, 118–122.Google Scholar
Hallahan, B, Ryan, T, Hibbeln, JR, Murray, IT, Glynn, S, Ramsden, CE, San Giovanni, JP, Davis, JM (2016). Efficacy of omega-3 highly unsaturated fatty acids in the treatment of depression. British Journal of Psychiatry 209, 192–201.CrossRefGoogle ScholarPubMed
Hamazaki, T, Sawazaki, S, Nagasawa, T, Nagao, Y, Kanagawa, Y, Yazawa, K (1999). Administration of docosahexaenoic acid influences behaviour and plasma catecholamine levels at times of psychological stress. Lipids 34, s33–s37.CrossRefGoogle ScholarPubMed
Hawton, K, Harris, L (2008). How often does deliberate self-harm occur relative to each suicide? A study of variations by gender and age. Suicide and Life Threatening Behaviour 38, 650–660.CrossRefGoogle ScholarPubMed
Itomura, M, Hamazaki, K, Sawazaki, S, Kobayashi, M, Terasawa, K, Watanabe, S, Hamazaki, T (2005). The effect of fish oil on physical aggression in schoolchildren – a randomized, double-blind, placebo-controlled trial. Journal of Nutrition and Biochemistry 16, 163–171.CrossRefGoogle ScholarPubMed
Lester, D (2002). Serum cholesterol levels and suicide: a meta-analysis. Suicide and Life Threatening Behaviour 32, 333–436.CrossRefGoogle ScholarPubMed
Luciano, JV, Bertsch, J, Salvador-Carulla, L (2010). Factor structure, internal consistence and construct validity of the Sheehan Disability Scale in a Spanish primary care sample. Journal of Evaluation of Clinical Practice 16, 895–901.Google Scholar
McPherson, A, Martin, CR (2010). A narrative review of the Beck Depression Inventory (BDI) and implications for its use in an alcohol-dependent population. Journal of Psychiatric Mental Health Nursing 17, 19–30.Google Scholar
Mukherjee, PK, Marcheselli, VL, Barreiro, S, Hu, J, Bok, D, Baznan, NG (2007). Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotection D1 signalling. Proclamations of the National Academy of Science USA 104, 13152–13157.Google Scholar
Oude Voshaar, RC, Cooper, J, Murphy, E, Steeg, S, Kapur, N, Purandare, NB (2011). First episode of self-harm in older age: a report from the 10-year prospective Manchester Self-Harm project. Journal of Clinical Psychiatry 72, 737–743.Google Scholar
Patton, JH, Stanford, MS, Barratt, ES (1995). Factor structure of the Barratt Impulsiveness Scale. Journal of Clinical Psychology 51, 768–774.Google Scholar
Sheehan, DV (1983). The Anxiety Disease. Charles Scribner and Sons: New York.Google Scholar
Tsai, AS, Lucas, M, Okereke, OI, O’Reilly, EJ, Mirzaei, F, Kawachi, I, Ascheiro, A, Willett, WC (2014) Suicide mortality in relation to dietary intake of n-3 nd n-6 polyunsaturated fatty acids and fish: equivocal findings from 3 large US cohort studies. American Journal of Epidemiology 179, 1458–1466.Google Scholar
Umhau, JC, Zhou, W, Carson, RE, Rapoport, SI, Polozova, A, Demar, J, Hussein, N, Bhattacharjee, AK, Ma, K, Esposito, G, Majchrzak, S, Herscovitch, P, Eckelman, WC, Kurdziel, KA, Salem, N Jr (2009) Imaging incorporation of circulating docosahexaenoic acid into the human brain using positron emission tomography. Journal of Lipid Research 50, 1259–1268.Google Scholar