Skip to main content
×
×
Home

Positron emission tomography in the study of neuropsychiatric disorders – its uses and potential

  • Raymond J Dolan (a1)
Abstract

PET represents the most powerful tool available for the measurement of in-vivo brain function. The basic principles of the technique and its application to the study of brain energy metabolism and neuroreceptor function are described by reference to findings from clinical studies of cerebral metabolism in neurological and psychiatric disorders. The extension of such resting state investigations by the application of activation paradigms in dynamic studies is discussed. The potential of PET as a tool to investigate neuroreceptor function is outlined in the context of preliminary findings from studies of dopaminergic function in schizophrenic patients.

Copyright
References
Hide All
1.Eichling, JO, Higgins, CS, Ter-pogossian, MM. Determination of radionuclide concentrations with positron CT scanning. J Nucl Med 1977; 18: 845847.
2.Phelps, ME, Maziotta, JC, Schelbert, H. Positron emission tomography and autoradiography: principles and applications for the brain and heart. New York: Raven Press, 1986.
3.Ter-Pogossian, MM, Phelps, ME. A positron emission tranxial tomography for nuclear imaging (PET). Radiology 1975; 114: 8998.
4.Huang, SC, Hoffman, SC, Phelps, ME, Kuhl, DE. Quantitation in positron emission tomography: 2. Effects of inaccurate attenuation correction. J Comp Ass Tomog 1979; 3: 804814
5.Hoffman, EJ, Huang, SC, Phelps, ME. Quantitation in positron emission computed tomography: i. Effects of object size. J Comp Ass Tomog 1979; 3: 299308.
6.Siesjo, BK, eds. Brian energy metabolism. New York: John Wiley 1978.
7.Jones, T, Chesler, DA, Ter-pogossian, MM. The continuous inhalation of oxygen-15 for assessing regional oxygen extraction in the brain of man. Br J Radiol 1976; 49: 339343.
8.Frackowial, R, Lenzi, G, Jones, T, Heather, JD. Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 150 and positron emission tomography: theory, procedure and normal values. J Comp Ass Tomog 1980; 4: 727736.
9.Sokoloff, L, Reivich, M, Kennedy, C, et al.The [14C] deoxyglucose method for the measurement of local cerebral glucose utilisation: theory, procedure and normal values in the conscious and anesthesized albino rat. J Neurochem 1977; 28: 897916.
10.Phelps, ME, Huang, SC, Hoffman, EJ, Selin, EJ, Sokoloff, L, Kuhl, DE. Tomographic measurement of local glucose metabolic rate in humans with (F-18) 2-fluro-2-deoxy-D-glucose: validation of method. Ann Neurol 1979; 6: 371388.
11.deLeon, MJ, Ferris, SH, George, AEet al.Positron emission tomographic studies of aging and Alzheimer's disease. AJNR 1983; 4: 568571.
12.Duara, R, Margolin, RA, Robertson-Tchabo, EA. et al.Cerebral glucose utilization as measured with positron emission tomography in 21 resting healthy men between the ages of 21 and 83 years. Brain 1983; 106: 761775.
13.Kuhl, De, Metter, EJ, Riege, WHet al.Effects of human aging on patterns of local cerebral glucose utilization determined by the {18F} fluoro-deoxyglucose method. J Cereb Blood Flow Metab 1982; 2: 163171.
14.Baron, JC, Lebrun-Grandie, P, Collard, P, Crouzel, C, Mestelan, GT, Bousser, MG. Non-invasive measurement of blood flow, oxygen consumption and glucose utilization in the same brain locus in man by positron emission tomography. J Nucl Med 1982; 23: 391399.
15.Baron, JC, Rougemont, D, Soussaline, Fet al.Positron tomography investigation in humans of the local coupling among CBF, oxygen consumption and glucose utilization. J Cereb Blood Flow Metab 1983; 3(suppl 1): S242S243.
16.Gibbs, JM, Wise, R, Leenders, Ket al.The relationship of regional cerebral blood flow, blood volume, and oxygen metabolism in patients with carotid occlusion: Evaluation of perfusion reserve. J Cereb Blood Flow Metab 1983; 3(suppl 1): S590S591.
17.Wise, RJ, Bernardi, S, Frackowiak, RS, Legg, NJ, Jones, T. Serial observations in the pathophysiology of acute stroke. Brain 1983; 106: 197222.
18.Baron, JC, Bousser, MG, Comar, D, Castaigne, P. Crossed cerebellar diaschisis in human supratentorial brain infarction. Trans Am Neurol Ass 1981; 105: 459461.
19.Bogousslavsky, J, Ferrazzini, M, Regli, F, Assal, G, Tanabe, HDelaloye-Bischof, A. Manic delirium and frontal-like syndromes with paramedian infarction of the right thalamus. J Neurol Neurosurg Psychiatry 1988; 51: 116119.
20.Baron, JC, D'Antona, R, Pantano, P, Serdaru, M, Samson, Y, Bousser, MG. Effects of thalamic stroke on energy metabolism of the cerebral cortex. Brain 1986; 109: 12431259.
21.Reivich, M, Greenberg, J, Alavi, Aet al.The use of the 18F-fluorodeoxyglucose technique for mapping functional neural pathways in man. Acta Neurol Scand 1979; 60(suppl 72): 198199.
22.Lauter, JL, Formby, C, Fox, P, Herscovitch, P, Raichle, ME. Tonotopic organization in human auditory cortex as revealed by regional changes in cerebral blood flow. J Cereb Blood Flow Metab 1983; 3(suppl 1): S248S249.
23.Mazziotta, JC, Phelps, ME, Halgren, E. Local cerebral glucose metabolic responses to audio-visual stimulation and deprivation: Studies in human subjects with positron CT. Hum Neurobiol 1983; 2: 1123.
24.Greenberg, J, Reivich, M, Alavi, Aet al.Metabolic mapping of functional activity in human subjects with the (18F) fluorode-oxyglucose technique. Science 1981; 212: 678680.
25.Roland, P, Meyer, E, Yamamoto, Yet al.Dynamic positron emission tomography as a tool in neuroscience: Functional brain-mapping in normal human volunteers. J Cereb Blood Flow Metab 1981; 1(suppl. 1): S463S464.
26.Reivich, M, Alavi, A, Gur, RC. Positron emission tomographic studies of perceptual tasks. Ann Neurol 1984; 15(suppl): S61S65.
27.Petersen, SE, Fox, PT, Posner, MI, Raichle, Mintun M.. Positron emission tomographic studies of the cortical anatomy of single-word processing. Nature 1988; 331: 585589.
28.Frackowiak, RS, Pozzili, C, Legg, NLet al.Regional cerebral oxygen supply and utilization in dementia. Brain 1981; 104: 753778.
29.Frackowiak, RS, Pozzili, C, Legg, NLet al. A prospective study of regional cerebral blood flow and oxygen utilization in dementia using positron emission tomography and oxygen-15. J Cereb Blood Flow Metab 1981; 1(suppl 1): S453S454.
30.Kuhl, DE, Metter, EJ, Reign, WHet al.Local cerebral glucose utilization in elderly patients with depression, multiple infarct dementia and Alzheimer's disease. J Cereb Blood Flow Metab 1983; 3(suppl 1): S494S495.
31.Mesulam, MM. Slowly progressive aphasia without generalised dementia. Ann Neurol 1982; 11: 592598.
32.Kuhl, DE, Phelps, ME, Markham, C. et al.Cerebral metabolism and atrophy in Huntington's disease determined by 18FDG and computed tomographic scan. Ann Neurol 1982; 12: 425434.
33.Kuhl, DE, Markham, CH, Metter, EJ, Riege, WH, Phelps, ME, Mazziotta, JC. Local cerebral glucose utilization in symptomatic and pre-symptomatic Huntington's disease. In: Sokoloff, L, eds. Brain imaging and brain function. New York: Raven Press, 1985: 199209.
34.Brodie, JD, Christman, DR, Corona, JF, et al.Patterns of metabolic activity in the treatment of schizophrenia. Ann Neurol 1984; 15(suppl): S166S169.
35.Buchsbaum, MS, Kessler, R, Bunney, WE. et al.Simultaneous electroencephalography and cerebral glucography with positron emission tomography (PET) in normals and patients with schizophrenia. J Cereb Blool Flow Metab 1981; 1(suppl 1): S457S458.
36.Farkas, T, Reivich, M, Alazi, A, et al.The application of {18F)-2-deoxy-2-fluoro-d-glucose and positron emission tomography in the study of psychiatric conditions. In: Passonneau, JV, Hawkins, R, Lust, WDet al, eds. Cereb Metab Neural Funct. Baltimore: Williams & Wilkins, 1980: 403408.
37.Sheppard, G, Manchanda, R, Gruzelier, J, et al, (1983) Positron emission tomographic scanning in predominantly never-treated acute schizophrenic patients. Lancet 1983; 24/31: 14481452.
38.Weinberger, DR, Berman, KF, Illowsky, BP. Physiological dysfunction of dorso-lateral pre-frontal cortex in schizophrenia. Arch Gen Psychiatry 1988; 45: 609615.
39.Baxter, LR, Phelps, ME, Maziotta, JC, et al.Cerebral metabolic rates for glucose in mood disorders. Arch Gen Psychiatry 1985; 42: 441447.
40.Kuhl, DE, Metter, EJ, Reige, WHet al.Local cerebral glucose utilization in elderly patients with depression, multiple infarct dementia and Alzheimer's disease. J Cereb Blood Flow Metab 1983; 3(suppl 1): S494S495.
41.Perlmutter, JS, Raichle, ME. Regional blood flow in hemiparkinsonism. Neurology 1985; 35: 11271134.
42.Wolfson, LI, Leenders, KL, Brown, LL, Jones, T. Alterations of regional cerebral blood flow and oxygen metabolism in Parkinson's Disease. Neurology 1985; 35: 13991405.
43.Wong, DF, Gjedde, A, Wagner, HN. Quantification of neuroreceptors in the living human brain. I: Irreversible binding of ligands. J Cereb Blood Flow and Metab 1986; 6: 137146.
44.Farde, L, Hall, H, Ehrin, E, Sedvall, G. Quantitative analysis of D2 dopamine receptor binding in living human brain by PET. Science 1986; 231: 258261.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Irish Journal of Psychological Medicine
  • ISSN: 0790-9667
  • EISSN: 2051-6967
  • URL: /core/journals/irish-journal-of-psychological-medicine
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords