A glutathione deficiency in the red cells of certain Merino sheep

Elizabeth M. Tucker; L. Kilgour

doi:10.1017/S0021859600025892

Summary

Red cell GSH concentrations were measured in 83 pure-bred and 65 cross-bred Tasmanian Merino sheep. A bimodal distribution was found; 40% of sheep had mean GSH values of 27·3 ± 1·2 mg and 60% had 92·2 ± 1·5 mg/100 ml red cells. Family data are limited, but they suggest that this difference is under genetic control, the gene for low GSH levels being dominant to that for high. Unlike GSH-low type Finnish Landrace sheep, GSH-low type Merino sheep do not have lower than normal red cell sodium and potassium concentrations.

References

REFERENCES

Beutler, E., Duron, O. & Kelly, B. M. (1963). Improved method for the determination of blood glutathione. J. Lab. clin. Med. 61, 882–8.Google Scholar PubMed

Tucker, E. M. & Kilgour, L. (1970). An inherited glutathione deficiency and a concomitant reduction in potassium concentration in sheep red cells. Experientia 26, 203–4.CrossRef Google Scholar

Tucker, E. M. & Ellory, J. C. (1971). The cation composition of the red cells of sheep with an inherited deficiency of reduced glutathione. Res. vet. Sci. 12, 600–2.CrossRef Google Scholar PubMed

Crossref Citations

This article has been cited by the following publications. This list is generated based on data provided by Crossref.

Tucker, Elizabeth M. Ellory, J.C. and Kilgour, L. 1973. Determinations of amino acid, cation and reduced glutathione levels in the red cells of Awassi sheep (Ovis Aries). Comparative Biochemistry and Physiology Part A: Physiology, Vol. 46, Issue. 1, p. 103.

Board, P. G. Roberts, J. and Evans, J. V. 1974. The genetic control of erythrocyte reduced glutathione in Australian Merino sheep. The Journal of Agricultural Science, Vol. 82, Issue. 3, p. 395.

Tucker, Elizabeth M. 1974. A Shortened Life Span of Sheep Red Cells with a Glutathione Deficiency. Research in Veterinary Science, Vol. 16, Issue. 1, p. 19.

YOUNG, J. D. ELLORY, J. C. and TUCKER, ELIZABETH M. 1975. Amino acid transport defect in glutathione-deficient sheep erythrocytes. Nature, Vol. 254, Issue. 5496, p. 156.

Tucker, E. M. 1975. The Blood of Sheep. p. 123.

Hopkins, G. J. Roberts, J. and Evans, J. V. 1975. Red blood cell concentrations of reduced glutathione and potassium as biochemical markers of wool growth in Merino sheep. The Journal of Agricultural Science, Vol. 84, Issue. 3, p. 481.

Young, J.D. Nimmo, I.A. and Hall, J.G. 1975. The relationship between GSH, GSSG and non-GSH thiol in GSH-deficienct erythrocytes from finnish landrage and tasmanian merino sheep. Biochimica et Biophysica Acta (BBA) - General Subjects, Vol. 404, Issue. 1, p. 124.

Tucker, Elizabeth M. 1975. The life span of glutathione-deficient red cells in Tasmanian Merino sheep. Research in Veterinary Science, Vol. 19, Issue. 3, p. 343.

Young, J.D. and Nimmo, I.A. 1975. GSH biosynthesis in glutathione deficient erythrocytes from Finnish Landrace and Tasmanian Merino sheep. Biochimica et Biophysica Acta (BBA) - General Subjects, Vol. 404, Issue. 1, p. 132.

Agar, N.S. 1975. Glutathione polymorphism in the sheep red blood cells. International Journal of Biochemistry, Vol. 6, Issue. 12, p. 843.

Tucker, Elizabeth M. Kilgour, L. and Young, J. D. 1976. The genetic control of red cell glutathione deficiencies in Finnish Landrace and Tasmanian Merino sheep and in crosses between these breeds. The Journal of Agricultural Science, Vol. 87, Issue. 2, p. 315.

Smith, J.E. and Lee, M. 1976. How phlebotomy affects the erythrocyte metabolism of high- and low-glutathione sheep. Research in Veterinary Science, Vol. 21, Issue. 2, p. 127.

Board, P.G. Morris, R.J.H. and Peter, D.W. 1976. The enzymes of glutathione synthesis in erythrocytes from gsh-high and gsh-low type australian merino sheep. International Journal of Biochemistry, Vol. 7, Issue. 8, p. 381.

Millar, K.R. 1980. Haemoglobin types, blood parameters and erythrocyte glutathione in the New Zealand Romney and other breeds. New Zealand Veterinary Journal, Vol. 28, Issue. 12, p. 251.

Young, James D. Crowley, Charles and Tucker, Elizabeth M. 1981. Haemolysis of normal and glutathione-deficient sheep erythrocytes by selenite and tellurite. Biochemical Pharmacology, Vol. 30, Issue. 18, p. 2527.

Young, J. D. and Jarvis, S. M. 1981. Transport and Inherited Disease. p. 347.

ZANOTTI, MARTA GIULIANI, M. GRAZIA ROGNONI, G. and RIZZI, RITA 1988. Heritability of erythrocyte reduced glutathione (GSH) in “delle Langhe” sheep. Journal of Animal Breeding and Genetics, Vol. 105, Issue. 1-6, p. 384.

Haba, M. De La Moreno, A Llanes, D. and Tucker, E. M. 1988. Glutathione concentrations in the red cells of Merino sheep. The Journal of Agricultural Science, Vol. 110, Issue. 2, p. 401.

Rizzi, Rita Caroli, Anna Bolla, Patrizia Acciaioli, Anna and Pagnacco, Giulio 1988. Variability of reduced glutathione levels in Massese ewes and its effect on daily milk production. Journal of Dairy Research, Vol. 55, Issue. 3, p. 345.

RIZZI, R. ZANOTTI‐CASATI, M. and ROGNONI, G. 1988. Variability of reduced glutathione (GSH) levels in three different ovine populations bred in Italy1. Journal of Animal Breeding and Genetics, Vol. 105, Issue. 1-6, p. 218.

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A glutathione deficiency in the red cells of certain Merino sheep

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This article has been cited by the following publications. This list is generated based on data provided by Crossref.

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A glutathione deficiency in the red cells of certain Merino sheep

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