Skip to main content
×
Home
    • Aa
    • Aa
  • Access

Glucocorticoids and the ageing hippocampus

  • CARINA HIBBERD (a1), JOYCE L. W. YAU (a1) and JONATHAN R. SECKL (a1)
  • Published online: 06 February 2001
Abstract

Approximately 30% of human and mammalian populations develop cognitive impairments with ageing. Many of these impairments have been linked to dysfunction of the hippocampus, a well studied area of the medial-temporal lobe, which is involved in episodic memory and control of the hypothalamo-pituitary-adrenal stress axis and, thus, of glucocorticoid secretion. This paper reviews the growing body of studies which explore a possible relationship between lifetime exposure to glucocorticoids and hippocampal impairment. There is now strong evidence which associates hypercortisolemia in aged men with later cognitive dysfunction and this complements a wealth of rodent and other human data. We conclude with a discussion of possible pharmacological and behavioural interventions.

    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Glucocorticoids and the ageing hippocampus
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Glucocorticoids and the ageing hippocampus
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Glucocorticoids and the ageing hippocampus
      Available formats
      ×
Copyright
Corresponding author
Correspondence to Dr J. R. Seckl, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The Journal of Anatomy
  • ISSN: 0021-8782
  • EISSN: 1469-7580
  • URL: /core/journals/journal-of-anatomy
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: