OBJECTIVES/SPECIFIC AIMS: Background: Failure to involve hard-to-reachpopulations in clinical research denies the potential benefits of research tothe excluded groups, perpetuating health disparities. Employing community healthworkers (CHWs) may be an effective strategy to increase outreach and engagementof marginalized groups. CHWs are members of the target communities with apersonal commitment to help their neighbors, and who serve as informants andcommunicators among their peers. CHWs may be particularly effective inaddressing individual and cultural barriers to research participation. Becauseof their unique background and community-based roles, tailored training programsfor CHWs are needed. The Recruitment, Retention, and Community EngagementProgram at the UIC Center for Clinical and Translational Sciences seeks to trainCHWs to be involved in the recruitment and enrollment of participants inclinical trials. We developed an 8-hour training that covers basic researchmethods (e.g., randomized clinical trials, longitudinal studies); researchactivities (e.g., surveys, interviews); and research ethics. The trainingfocuses on the development of communication skills necessary for ethicalrecruitment and informed consent, providing strategies for addressing mistrust,fear and misunderstanding around the research process. Aim 1: To evaluate thefeasibility of the CHW training by assessing. Aim 1.1: Recruitment ofparticipants; Aim 1.2: Completion of training session (8 hr). Aim 2: To evaluateacceptability of training by assessing. Aim 2.1: Satisfaction with training; Aim2.2: Cultural competence of training content; Aim 2.3: Participant self-efficacyin reproducing information. Aim 3: To collect performance measures by assessing.Aim 3.1: Knowledge gain and retention; Aim 3.2: Self-efficacy in identifying andaddressing negative beliefs about research; Aim 3.3: Participants’readiness to refer and/or recommend participation in clinical trials.METHODS/STUDY POPULATION: Methods: This is a pilot study with asingle-group repeated-measures design with assessments at baseline, 1 weekpost-test, and 3- and 6-month follow-ups. We aim to recruit 25 CHWs working withorganizations serving the needs of ethnic minorities in Chicago. We willevaluate feasibility (recruitment, completion of training and assessments) andacceptability of the training (satisfaction with training, culturalappropriateness of content and delivery, participant self-efficacy inreproducing information). Performance measures assessed throughself-administered surveys at baseline, 1 week post-training, 3 months, and 6months will include knowledge, attitudes toward research, and self-efficacy inidentifying and addressing barriers to participation. Readiness to recruit andobtain informed consent will be assessed during an observed simulation activitywith a standardized participant. Data analysis: Demographic data will becollected, and descriptive and inferential analyses will be conducted. Pretestand post-test questionnaire data will be compared usingt-tests. In the informed consent simulation, individuals willbe scored on whether they adequately addressed required elements of the informedconsent process. Data gathered from the informed consent simulation will also beused for program evaluation and formative purposes; feedback on strengths andareas for improvement will be provided to participants.RESULTS/ANTICIPATED RESULTS: Expected results: It will be feasible toimplement the training of CHWs, reaching the expected goal of 25 participants,with at least 70% of them completing the 8-hour training. We expectto collect data demonstrating acceptability of the training with a score of“good” or “excellent” by70% of participants. At least 70% will rate the trainingas “culturally acceptable” or better, and will showimproved self-efficacy in the delivery of information from pretest to post-testby at least 30%. Performance measures will demonstrate improvementsin research knowledge by 30% from pretest to post-test; increasedself-efficacy in identifying and addressing negative beliefs about researchprocess, by at least 30%. A minimum of 70% of participantswill demonstrate readiness to refer and/or recommend participation inclinical trials by scoring at or above 70% in evaluation ofperformance with standardized participants. Evaluation of knowledge retention at3 and 6 months post-training will not take place before the TranslationalScience Conference in March 2018. DISCUSSION/SIGNIFICANCE OF IMPACT:Discussion/Impact. The outcomes of this evaluation may advance ourknowledge of community obstacles to participation in research, and shed light onsuccessful strategies to address them. Information obtained will be used toaddress limitations of the training. Even though the sample is small we expectto identify trends in quantitative measures that will support an application forfunding for a larger randomized study. Once we have developed an effectivetraining model, we expect to disseminate it to other CTSAs for broadimplementation.