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The role of platelet factor-4 (PF4 or CXCL4) in B cell differentiation

Published online by Cambridge University Press:  10 May 2018

Sara Blick ,
Craig Morrell ,
Sara Ture  and
David J. Field
Sara Blick
Affiliation:
Rochester Institute of Technology, Rochester, NY, USA
Craig Morrell
Affiliation:
Rochester Institute of Technology, Rochester, NY, USA
Sara Ture
Affiliation:
Rochester Institute of Technology, Rochester, NY, USA
David J. Field
Affiliation:
Rochester Institute of Technology, Rochester, NY, USA
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Abstract

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OBJECTIVES/SPECIFIC AIMS: To investigate the role of platelet factor-4 (PF4) in B cell differentiation and develop strategies to better modulate B cell differentiation in vitro and in vivo. METHODS/STUDY POPULATION: We use tissue culture and flow cytometry to examine the role of PF4 in B cell differentiation. We use wild type (WT) and PF4−/− mice on a C57Bl6/J background. PF4−/− mice have reduced in vivo B cell differentiation responses. RESULTS/ANTICIPATED RESULTS: We anticipate that our studies will demonstrate that PF4 promotes B cell differentiation in the bone marrow microenvironment. DISCUSSION/SIGNIFICANCE OF IMPACT: The significance of this project may be valuable in developing efficient methods and strategies to increase or limit B cell numbers in vitro and in human disease.

Type
Basic Science/Methodology
Information
Journal of Clinical and Translational Science , Volume 1 , Supplement S1 , September 2017 , pp. 10
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Association for Clinical and Translational Science 2018