Hostname: page-component-8448b6f56d-tj2md Total loading time: 0 Render date: 2024-04-23T23:49:26.773Z Has data issue: false hasContentIssue false
  • English
  • Français

Cooling management effects on dry matter intake, metabolic hormones levels and welfare parameters in dairy cows during heat stress

Published online by Cambridge University Press:  02 March 2020

Alona Kleinjan-Elazary ,
Yehoshav Ben-Meir ,
Haim Gacitua ,
Harel Levit ,
Avia Fridman ,
Dima Shinder ,
Shamay Jacoby ,
Joshua Miron ,
Ilan Halachmi  and
Eran Gershon
Alona Kleinjan-Elazary
Affiliation:
Department of Ruminant Science, Agricultural Research Organization, PO Box 6, Rishon LeZion50250, Israel Department of Animal Sciences, The Robert H. Smith Faculty of Agriculture, Food, and Environment, The Hebrew University of Jerusalem, Rehovot7612001, Israel
Yehoshav Ben-Meir
Affiliation:
Department of Ruminant Science, Agricultural Research Organization, PO Box 6, Rishon LeZion50250, Israel Department of Animal Sciences, The Robert H. Smith Faculty of Agriculture, Food, and Environment, The Hebrew University of Jerusalem, Rehovot7612001, Israel
Haim Gacitua
Affiliation:
Department of Ruminant Science, Agricultural Research Organization, PO Box 6, Rishon LeZion50250, Israel
Harel Levit
Affiliation:
Department of Animal Sciences, The Robert H. Smith Faculty of Agriculture, Food, and Environment, The Hebrew University of Jerusalem, Rehovot7612001, Israel Agricultural Engineering, Agricultural Research Organization, PO Box 6, Rishon LeZion50250, Israel
Avia Fridman
Affiliation:
Department of Ruminant Science, Agricultural Research Organization, PO Box 6, Rishon LeZion50250, Israel
Dima Shinder
Affiliation:
Poultry and Aquaculture Sci. Department, Agricultural Research Organization, PO Box 6, Rishon LeZion50250, Israel
Shamay Jacoby
Affiliation:
Department of Ruminant Science, Agricultural Research Organization, PO Box 6, Rishon LeZion50250, Israel
Joshua Miron
Affiliation:
Department of Ruminant Science, Agricultural Research Organization, PO Box 6, Rishon LeZion50250, Israel
Ilan Halachmi
Affiliation:
Agricultural Engineering, Agricultural Research Organization, PO Box 6, Rishon LeZion50250, Israel
Eran Gershon*
Affiliation:
Department of Ruminant Science, Agricultural Research Organization, PO Box 6, Rishon LeZion50250, Israel
*
Author for correspondence: Eran Gershon, Email: eran.gershon1@mail.huji.ac.il
Get access Rights & Permissions [Opens in a new window]

Abstract

This research paper addresses the hypothesis that intensive cooling management during the summer improves the secretion of metabolic hormones in dairy cows. To test this hypothesis, we characterized the effect of different cooling managements on the different ghrelin isoforms and leptin secretion of 20 Israeli-Holstein dairy cows during 5 weeks during heat stress. The cows were divided into two groups: one was exposed to 5 cooling sessions per day (5 CS) and the other to 8 cooling sessions per day (8 CS). Blood was collected and leptin and ghrelin isoforms level were radioimmunoassayed. Analysis of the interaction between coolings and the week of the experiment showed that the 8 CS group consumed more food and produced more milk, although neither difference was statistically significant. In addition, the 8 CS group exhibited higher blood levels of acyl-ghrelin and leptin as compared to the 5 CS group. Conversely, the blood levels of total ghrelin were lower in the cows exposed to 8 CS as compared to cows from the 5 CS treatment. Furthermore, a significant correlation was found only between total ghrelin levels and the weeks, but not with other parameters examined. We further compared digestibility as well as stress parameters between the groups. We found that the 8 CS group cows ruminated and lay down more hours during a day and simultaneously had better activity time. No significant difference was detected between groups in milk yield and digestibility parameters. Our results suggest that intensive cooling management during the hot season influences the levels of metabolic hormones in the circulation and helps to mitigate the detrimental effect of heat stress on dairy cow welfare and production.

Keywords

Cooling managementDMIGhrelinheat stressLeptin
Type
Research Article
Information
Journal of Dairy Research , Volume 87 , Issue 1 , February 2020 , pp. 64 - 69
Copyright
Copyright © Hannah Dairy Research Foundation 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Allen, JD, Hall, LW, Collier, RJ and Smith, JF (2015) Effect of core body temperature, time of day, and climate conditions on behavioral patterns of lactating dairy cows experiencing mild to moderate heat stress. Journal of Dairy Science 98, 118–127.Google ScholarPubMed
Asakawa, A, Inui, A, Fujimiya, M, Sakamaki, R, Shinfuku, N, Ueta, Y, Meguid, MM and Kasuga, M (2005) Stomach regulates energy balance Via Acylated ghrelin and desacyl ghrelin. Gut 54, 18–24.Google ScholarPubMed
Berman, A (2006) Extending the potential of evaporative cooling for heat-stress relief. Journal of Dairy Science 89, 3817–3825.10.3168/jds.S0022-0302(06)72423-7Google ScholarPubMed
Borner, S, Derno, M, Hacke, S, Kautzsch, U, Schaff, C, Thanthan, S, Kuwayama, H, Hammon, HM, Rontgen, M, Weikard, R, Kuhn, C, Tuchscherer, A and Kuhla, B (2013) Plasma ghrelin is positively associated with body fat, liver fat and milk fat content but not with feed intake of dairy cows after parturition. Journal of Endocrinology 216, 217–229.Google Scholar
Bradford, BJ and Allen, MS (2008) Negative energy balance increases periprandial ghrelin and growth hormone concentrations in lactating dairy cows. Domestic Animal Endocrinology 34, 196–203.Google ScholarPubMed
Budak, E, Fernandez Sanchez, M, Bellver, J, Cervero, A, Simon, C and Pellicer, A (2006) Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36 with the reproductive system. Fertility and Sterility 85, 1563–1581.10.1016/j.fertnstert.2005.09.065Google ScholarPubMed
Burfeind, O, Suthar, VS and Heuwieser, W (2012) Effect of heat stress on body temperature in healthy early postpartum dairy cows. Theriogenology 78, 2031–2038.10.1016/j.theriogenology.2012.07.024Google ScholarPubMed
Chen, CY, Inui, A, Asakawa, A, Fujino, K, Kato, I, Chen, CC, Ueno, N and Fujimiya, M (2005) Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats. Gastroenterology 129, 8–25.Google ScholarPubMed
Collier, RJ, Beede, DK, Thatcher, WW, Israel, LA and Wilcox, CJ (1982) Influences of environment and its modification on dairy animal health and production. Journal of Dairy Science 65, 2213–2227.Google Scholar
de la Hoya MPGTR, JA, Contreras, PR, Diaz, CEP, Saucedo, FOR and Saucedo, JSQ (2015) Role of leptin in cattle production: review. Journal of Animal and Veterinary Advances 14, 81–90.Google Scholar
De Rensis, F and Scaramuzzi, RJ (2003) Heat stress and seasonal effects on reproduction in the dairy cow--a review. Theriogenology 60, 1139–1151.10.1016/S0093-691X(03)00126-2Google ScholarPubMed
Dickin, JC, Thue, TD and Buchanan, FC (2004) An alternative splice site in ghrelin is missing in ruminants. Animal Genetics 35, 411–412.Google ScholarPubMed
Fernandez-Fernandez, R, Martini, AC, Navarro, VM, Castellano, JM, Dieguez, C, Aguilar, E, Pinilla, L and Tena-Sempere, M (2006) Novel signals for the integration of energy balance and reproduction. Molecular and Cellular Endocrinology 254–255, 127–132.Google ScholarPubMed
Flamenbaum, I and Galon, N 2010 Management of heat stress to improve fertility in dairy cows in Israel. Journal of Reproduction and Development 56(suppl.) S36–S4110.1262/jrd.1056S36Google ScholarPubMed
Flamenbaum, I, Wolfenson, D, Mamen, M and Berman, A (1986) Cooling dairy cattle by a combination of sprinkling and forced ventilation and its implementation in the shelter system. Journal of Dairy Science 69, 3140–3147.Google ScholarPubMed
Foote, AP, Hales, KE, Lents, CA and Freetly, HC (2014) Association of circulating active and total ghrelin concentrations with dry matter intake, growth, and carcass characteristics of finishing beef cattle. Journal of Animal Science 92, 5651–5658.10.2527/jas.2014-8291Google ScholarPubMed
Gentry, PC, Willey, JP and Collier, RJ (2003) Ghrelin, a growth hormone secretagogue, is expressed by bovine rumen. Journal of Animal Science 81, 123.Google Scholar
Gutierrez, JA, Solenberg, PJ, Perkins, DR, Willency, JA, Knierman, MD, Jin, Z, Witcher, DR, Luo, S, Onyia, JE and Hale, JE (2008) Ghrelin octanoylation mediated by an orphan lipid transferase. Proceedings of the National Academy of Sciences of the United States of America 105, 6320–6325.Google ScholarPubMed
Hayashida, T, Murakami, K, Mogi, K, Nishihara, M, Nakazato, M, Mondal, MS, Horii, Y, Kojima, M, Kangawa, K and Murakami, N (2001) Ghrelin in domestic animals: distribution in stomach and its possible role. Domestic Animal Endocrinology 21, 17–24.10.1016/S0739-7240(01)00104-7Google ScholarPubMed
Her, E, Wolfenson, D, Flamenbaum, I, Folman, Y, Kaim, M and Berman, A (1988) Thermal, productive, and reproductive responses of high yielding cows exposed to short-term cooling in summer. Journal of Dairy Science 71, 1085–1092.Google Scholar
Honig, H, Miron, J, Lehrer, H, Jackoby, S, Zachut, M, Zinou, A, Portnick, Y and Moallem, U (2012) Performance and welfare of high-yielding dairy cows subjected to 5 or 8 cooling sessions daily under hot and humid climate. Journal of Dairy Science 95, 3736–3742.Google ScholarPubMed
Honig, H, Ofer, L, Elbaz, M, Kaim, M, Shinder, D and Gershon, E (2016) Seasonal and parity effects on ghrelin levels throughout the estrous cycle in dairy cows. General and Comparative Endocrinology 235, 64–69.Google ScholarPubMed
Hosoda, H, Kojima, M, Matsuo, H and Kangawa, K (2000) Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochemical and Biophysical Research Communications 279, 909–913.Google ScholarPubMed
Kojima, M, Hosoda, H, Date, Y, Nakazato, M, Matsuo, H and Kangawa, K (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402, 656–660.Google ScholarPubMed
Liefers, SC, Veerkamp, RF, te Pas, MF, Delavaud, C, Chilliard, Y and van der Lende, T (2003) Leptin concentrations in relation to energy balance, milk yield, intake, live weight, and estrus in dairy cows. Journal of Dairy Science 86, 799–80710.3168/jds.S0022-0302(03)73662-5Google ScholarPubMed
Miura, H, Tsuchiya, N, Sasaki, I, Kikuchi, M, Kojima, M, Kangawa, K, Hasegawa, Y and Ohnami, Y (2004) Changes in plasma ghrelin and growth hormone concentrations in mature Holstein cows and three-month-old calves. Journal of Animal Science 82, 1329–1333.10.2527/2004.8251329xGoogle ScholarPubMed
Moretti, R, Biffani, S, Chessa, S and Bozzi, R (2017) Heat stress effects on Holstein dairy cows' rumination. Animal: An International Journal of Animal Bioscience 11, 2320–2325.10.1017/S1751731117001173Google ScholarPubMed
Muccioli, G, Lorenzi, T, Lorenzi, M, Ghe, C, Arnoletti, E, Raso, GM, Castellucci, M, Gualillo, O and Meli, R (2011) Beyond the metabolic role of ghrelin: a new player in the regulation of reproductive function. Peptides 32, 2514–2521.Google ScholarPubMed
Silanikove, N (2000) Effects of heat stress on the welfare of extensively managed domestic ruminants. Livestock Production Science 67, 1–18.10.1016/S0301-6226(00)00162-7Google Scholar
Sugino, T, Yamaura, J, Yamagishi, M, Ogura, A, Hayashi, R, Kurose, Y, Kojima, M, Kangawa, K, Hasegawa, Y and Terashima, Y (2002) A transient surge of ghrelin secretion before feeding is modified by different feeding regimens in sheep. Biochemical and Biophysical Research Communications 298, 785–788.Google Scholar
ThidarMyint, H, Yoshida, H, Ito, T and Kuwayama, H (2006) Dose-dependent response of plasma ghrelin and growth hormone concentrations to bovine ghrelin in Holstein heifers. Journal of Endocrinology 189, 655–664.10.1677/joe.1.06746Google ScholarPubMed
van der Lely, AJ, Tschop, M, Heiman, ML and Ghigo, E (2004) Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocrine Reviews 25, 426–457.Google ScholarPubMed
Wertz-Lutz, AE, Knight, TJ, Pritchard, RH, Daniel, JA, Clapper, JA, Smart, AJ, Trenkle, A and Beitz, DC (2006) Circulating ghrelin concentrations fluctuate relative to nutritional status and influence feeding behavior in cattle. Journal of Animal Science 84, 3285–3300.Google ScholarPubMed
West, JW (2003) Effects of heat-stress on production in dairy cattle. Journal of Dairy Science 86, 2131–2144.Google ScholarPubMed
Yang, J, Brown, MS, Liang, G, Grishin, NV and Goldstein, JL (2008) Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132, 387–396.Google ScholarPubMed
Supplementary material: PDF

Kleinjan-Elazary et al. supplementary material

Kleinjan-Elazary et al. supplementary material

Download Kleinjan-Elazary et al. supplementary material(PDF)
PDF 222.1 KB