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Early infancy – a critical period for development of obesitya

Published online by Cambridge University Press:  06 July 2010

M. W. Gillman
M. W. Gillman*
Affiliation:
Obesity Prevention Program, Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Health Care Institute, Boston, MA, USA
*
*Address for correspondence: Dr Matthew W. Gillman, Obesity Prevention Program, Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, 6th floor, Boston, MA 02215, USA. (Email matthew_gillman@hms.harvard.edu)
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Abstract

Abundant epidemiologic evidence from the developed world now shows that more rapid weight gain during the first half of infancy predicts later obesity and cardio-metabolic risk. In countries in transition, in which stunting is still prevalent, distinguishing the effects of gain in weight from linear growth remains a challenge. Moreover, very few studies to date have incorporated body composition measures during infancy, which is key to understanding determinants of infant weight gain that also predict later obesity. In addition to infant feeding type, potential determinants include the perinatal endocrine milieu. Animal and emerging human data raise the possibility that ensuring adequate leptin exposure to the growing fetus may regulate energy balance as the infant grows. Understanding these pathways, as well as examining the balance between cardiovascular and cognitive effects in both term and preterm infants, will point the way toward effective interventions to alter infant growth to prevent later obesity.

Keywords

growthinfancyleptinobesityweight gain
Type
Reviews
Information
Journal of Developmental Origins of Health and Disease , Volume 1 , Issue 5 , October 2010 , pp. 292 - 299
Copyright
Copyright © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2010

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Footnotes

a

Presented in part at the 6th World Congress on Developmental Origins of Health and Disease, Santiago, Chile, November 2009, and at the 65th Nestlé Nutrition Institute Workshop, Importance of Growth for Health and Development, Kuala Lumpur, Malaysia, March 2009.

References

1. Kim, J, Peterson, KE, Scanlon, KS, et al. Trends in overweight from 1980 through 2001 among preschool-aged children enrolled in a health maintenance organization. Obesity (Silver Spring). 2006; 14, 1107–1112.CrossRefGoogle Scholar
2. Leibel, RL. Molecular physiology of weight regulation in mice and humans. Int J Obes (Lond). 2008; 32(Suppl 7), S98–S108.CrossRefGoogle ScholarPubMed
3. Gardner, DS, Hosking, J, Metcalf, BS, et al. Contribution of early weight gain to childhood overweight and metabolic health: a longitudinal study (EarlyBird 36). Pediatrics. 2009; 123, e67–e73.CrossRefGoogle Scholar
4. Gillman, MW. Early infancy as a critical period for development of obesity and related conditions. Nestlé Nutr Workshop. 2010; 65, 13–24.CrossRefGoogle ScholarPubMed
5. Veldhuis, JD, Roemmich, JN, Richmond, EJ, Bowers, CY. Somatrotropic and gonadotropic axes linkages in infancy, childhood, and the puberty-adult transition. Endocr Rev. 2006; 27, 101–140.CrossRefGoogle Scholar
6. Butte, NF, Hopkinson, JM, Wong, WW, Smith, EO, Ellis, KJ. Body composition during the first 2 years of life: an updated reference. Pediatr Res. 2000; 47, 578–585.Google Scholar
7. Widdowson, EM, McCance, RA. The effect of finite periods of undernutrition at different ages on the composition and subsequent development of the rat. Proc R Soc Lond [Biol]. 1963; 158, 329–342.Google ScholarPubMed
8. Vickers, MH. Developmental programming and adult obesity: the role of leptin. Curr Opin Endocrinol Diabetes Obes. 2007; 14, 17–22.CrossRefGoogle ScholarPubMed
9. Baird, J, Fisher, D, Lucas, P, et al. Being big or growing fast: systematic review of size and growth in infancy and later obesity. BMJ. 2005; 331, 929–934.CrossRefGoogle ScholarPubMed
10. Ong, KK, Loos, RJ. Rapid infancy weight gain and subsequent obesity: systematic reviews and hopeful suggestions. Acta Paediatr. 2006; 95, 904–908.Google Scholar
11. Monteiro, PO, Victora, CG. Rapid growth in infancy and childhood and obesity in later life – a systematic review. Obes Rev. 2005; 6, 143–154.CrossRefGoogle ScholarPubMed
12. Yliharsila, H, Kajantie, E, Osmond, C, et al. Body mass index during childhood and adult body composition in men and women aged 56 to 70 years. Am J Clin Nutr. 2008; 87, 1769–1775.CrossRefGoogle Scholar
13. Barker, DJP, Osmond, C, Forsen, TJ, Kajantie, E, Eriksson, JG. Trajectories of growth among children who later have coronary events. N Engl JMed. 2005; 353, 1802–1809.Google Scholar
14. Botton, J, Heude, B, Maccario, J, et al. Postnatal weight and height growth velocities at different ages between birth and 5 years and body composition in adolescent boys and girls. Am J Clin Nutr. 2008; 87, 1760–1768.CrossRefGoogle ScholarPubMed
15. Chomtho, S, Wells, JC, Williams, JE, et al. Infant growth and later body composition: evidence from the 4-component model. Am J Clin Nutr. 2008; 87, 1776–1784.CrossRefGoogle ScholarPubMed
16. Belfort, MB, Rifas-Shiman, SL, Rich-Edwards, J, Kleinman, KP, Gillman, MW. Size at birth, infant growth, and blood pressure at three years of age. J Pediatr. 2007; 151, 670–674.Google Scholar
17. Taveras, EM, Rifas-Shiman, SL, Belfort, MB, et al. Weight status in the first 6 months of life and obesity at 3 years of age. Pediatrics. 2009; 123, 1177–1183.CrossRefGoogle ScholarPubMed
18. Ben Shlomo, Y, McCarthy, A, Hughes, R, et al. Immediate postnatal growth is associated with blood pressure in young adulthood: the Barry Caerphilly growth study. Hypertension. 2008; 52, 638–644.CrossRefGoogle ScholarPubMed
19. Ekelund, U, Ong, KK, Linne, Y, et al. Association of weight gain in infancy and early childhood with metablic risk in young adults. J Clin Endocrinol Metab. 2007; 1, 98–103.CrossRefGoogle Scholar
20. Leunissen, RW, Kerkhof, GF, Stijnen, T, Hokken-Koelega, A. Timing and tempo of first-year rapid growth in relation to cardiovascular and metabolic risk profile in early adulthood. JAMA. 2009; 301, 2234–2242.CrossRefGoogle ScholarPubMed
21. Centers for Disease Control and Prevention. Retrieved 8 December 2009 from http://www.cdc.gov.GrowthCharts/ Google Scholar
22. Taveras, EM, Rifas-Shiman, SL, Oken, E, et al. (2008) Crossing growth percentiles in infancy and risk of obesity at age 5. 2008 Pediatric Academic Societies’ Annual Meeting, Honolulu, HI, May 2–6.Google Scholar
23. deBeer, M, van Eijsden, M, Vrijkotte, TGM, Gemke, RJBJ. Relation of early weight gain with body size, body composition and fat distribution at the age of 5 in a prospective birth cohort: the ABCD study. J Dev Orig Health Dis. 2009; 1(Suppl 1), s18–s19.Google Scholar
24. Terry, MB, Wei, Y, Esserman, D, McKeague, I, Susser, E. Pre- and postnatal determinants of childhood body size. J Dev Orig Health Dis. 2009; 1(Suppl 1), s31.Google Scholar
25. Singhal, A, Lucas, A. Early Origins of cardiovascular disease: is there a unifying hypothesis? Lancet. 2004; 363, 1642–1645.CrossRefGoogle Scholar
26. Singhal, A, Cole, TJ, Fewtrell, M, et al. Promotion of faster weight gain in infants born small for gestational age: is there an adverse effect on later blood pressure? Circulation. 2007; 115, 213–220.CrossRefGoogle ScholarPubMed
27. Stettler, N, Stallings, VA, Troxel, AB, et al. Weight gain in the first week of life and overweight in adulthood: a cohort study of European American subjects fed infant formula. Circulation. 2005; 111, 1897–1903.CrossRefGoogle ScholarPubMed
28. Adair, LS, Martorell, R, Stein, AD, et al. Size at birth, weight gain in infancy and childhood, and adult blood pressure in 5 low- and middle-income-country cohorts: when does weight gain matter? Am J Clin Nutr. 2009; 89, 1383–1392.CrossRefGoogle ScholarPubMed
29. Sachdev, HS, Fall, CH, Osmond, C, et al. Anthropometric indicators of body composition in young adults: relation to size at birth and serial measurements of body mass index in childhood in the New Delhi birth cohort. Am J Clin Nutr. 2005; 82, 456–466.CrossRefGoogle ScholarPubMed
30. Joglekar, C, Yajnik, CS, Osmond, C, Fall, C. Newborn size, postnatal growth and cardiovascular risk factors and body composition at 12 years (Pune Maternal Nutrition Study). J Dev Orig Health Dis. 2009; 1(Suppl 1), s19–s20.Google Scholar
31. Slining, MM, Adiar, LS. Early rapid weight gain and insulin resistance in young adulthood: evidence from the Cebu Longitudinal Health and Nutrition Study. J Dev Orig Health Dis. 2009; 1(Suppl 1), s30–s31.Google Scholar
32. Fernandes, MTB, Ferraro, AA, Bassotto, AP, Santos, E, Schwartsman, C. Association between catch-up in the first years of life and overweight/obesity at 10 years of age, in a low-income community in Sao Paulo, Brazil. J Dev Orig Health Dis. 2009; 1(Suppl 1), s204–s205.Google Scholar
33. Corvalan, C, Uauy, R, Lera, L, Galvan, M, Kain, J. Body mass index and height growth from birth to 4 y and body composition at 5 y in Chilean children with normal birthweight. J Dev Orig Health Dis. 2009; 1(Suppl 1), s204.Google Scholar
34. Rifas-Shiman, SL, Rich-Edwards, JW, Scanlon, KS, Kleinman, K, Gillman, MW. Misdiagnosis of overweight and underweight children younger than 2 years of age due to length measurement bias. MedGenMed. 2005; 7, 56.Google Scholar
35. Owen, CG, Martin, RM, Whincup, P, Davey Smith, G, Cook, DG. Effect of infant feeding on the risk of obesity across the life course: a quantitative review of published evidence. Pediatrics. 2005; 115, 1367–1377.CrossRefGoogle ScholarPubMed
36. Kramer, MS, Guo, T, Platt, RW, et al. Breastfeeding and infant growth: biology or bias? Pediatrics. 2002; 110, 343–347.CrossRefGoogle ScholarPubMed
37. Kramer, MS, Guo, T, Platt, RW, et al. Feeding effects on growth during infancy. J Pediatr. 2004; 145, 600–605.CrossRefGoogle ScholarPubMed
38. Koletzko, B, von Kries, R, Closa, R, et al. Lower protein in infant formula is associated with lower weight up to age 2 y: a randomized clinical trial. Am J Clin Nutr. 2009; 89, 1836–1845.CrossRefGoogle ScholarPubMed
39. Gillman, MW, Rifas-Shiman, S, Kleinman, K, et al. Developmental origins of childhood overweight: potential public health impact. Obesity (Silver Spring). 2008; 16, 1651–1656.CrossRefGoogle ScholarPubMed
40. Parker, M, Rifas-Shiman, SL, Belfort, MB et al. , Pre- and perinatal predictors of weight gain in early infancy 2009. Pediatric Academic Societies’ Annual Meeting, Baltimore, MD.Google Scholar
41. Pennell, CE, Ang, QW, Marsh, JA, et al. Gene-environment interactions between the fat mass and obesity-associated (fto) gene and nutrition modify the association between Fto and obesity in childhood and adolescence. J Dev Orig Health Dis. 2009; 1(Suppl 1), s34–s35.Google Scholar
42. deBeer, M, Vrijkotte, TGM, van der Wal, MF, van Weissenbruch, MM, Gemke, RJBJ. Relation of maternal hypertension with infant growth: the ABCD study. J Dev Orig Health Dis. 2009; 1(Suppl 1), s66–s67.Google Scholar
43. Algera, SJ, Twickler, ThB, van Eijsden, M, Vrijkotte, TGM. Maternal lipid profile in early pregnancy in relation to prenatal and postnatal growth. J Dev Orig Health Dis. 2009; 1(Suppl 1), s125.Google Scholar
44. Regnault, N, Dargent-Molina, P, Botton, J, et al. Higher serum C-peptide concentrations are associated with slower growth rate in the first year of life in girls. J Dev Orig Health Dis. 2009; 1(Suppl 1), s169–s170.Google Scholar
45. Lang, IA, Galloway, TS, Scarlett, A, et al. Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. JAMA. 2008; 300, 1303–1310.CrossRefGoogle ScholarPubMed
46. Turnbaugh, PJ, Ley, RE, Mahowald, MA, et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006; 444, 1027–1031.CrossRefGoogle ScholarPubMed
47. Fleisch, AF, Agarwal, N, Roberts, MD, et al. Influence of serum leptin on weight and body fat growth in children at high risk for adult obesity. J Clin Endocrinol Metab. 2007; 92, 948–954.CrossRefGoogle ScholarPubMed
48. Johnson, MS, Huang, TT, Figueroa-Colon, R, Dwyer, JH, Goran, MI. Influence of leptin on changes in body fat during growth in African American and white children. Obes Res. 2001; 9, 593–598.CrossRefGoogle ScholarPubMed
49. Mantzoros, CS, Rifas-Shiman, SL, Williams, CJ, et al. Cord blood leptin and adiponectin as predictors of adiposity in children at 3 years of age: a prospective cohort study. Pediatrics. 2009; 123, 682–689.CrossRefGoogle ScholarPubMed
50. Bouret, SG, Draper, SJ, Simerly, R. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science. 2004; 304, 108–110.CrossRefGoogle ScholarPubMed
51. Vickers, MH, Gluckman, PD, Coveny, AH, et al. Neonatal leptin treatment reverses developmental programming. Endocrinology. 2005; 146, 4211–4216.CrossRefGoogle ScholarPubMed
52. Sanchez, J, Priego, T, Palou, M, et al. Oral supplementation with physiological doses of leptin during lactation in rats improves insulin sensitivity and affects food preferences later in life. Endocrinology. 2008; 149, 733–740.CrossRefGoogle ScholarPubMed
53. Ehrenkranz, RA, Dusick, AM, Vohr, BR, et al. Growth in neonatal intensive care unit influences neurodevelopmental and growth outcomes of extremely low birth weight infants. Pediatrics. 2006; 117, 1253–1261.Google Scholar
54. Casey, PH, Whiteside-Mansell, L, Barrett, K, Bradley, RH, Gargus, R. Impact of prenatal and/or postnatal growth problems in low birth weight preterm infants on school-age outcomes: an 8-year longitudinal evaluation. Pediatrics. 2006; 118, 1078–1086.CrossRefGoogle ScholarPubMed
55. Belfort, MB, Martin, CR, Gillman, MW, McCormick, MC Does more rapid infant weight gain lead to higher blood pressure or better neurodevelopment in former preterm infants? 2009. 2009 Pediatric Academic Socities’ Annual Meeting, Baltimore, MD, May 2–5.Google Scholar
56. Washburn, LK, Nixon, PA, Snively, BM, O’Shea, TM. Early weight gain and outcomes at 9 years in very low birth weight children. J Dev Orig Health Dis. 2009; 1(Suppl 1), s223–s224.Google Scholar
57. Belfort, MB, Rifas-Shiman, SL, Rich-Edwards, JW, et al. Infant growth and child cognition at 3 years of age. Pediatrics. 2008; 122, e689–e695.CrossRefGoogle ScholarPubMed