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Exposure to p,p´-DDE during early pregnancy, anthropometry, and gestational age at birth, in a flower-growing region of Mexico
Published online by Cambridge University Press: 20 May 2022
Abstract
Prenatal exposure to dichlorodiphenyldichloroethylene (p,p´-DDE) may interfere with fetal development; however, studies evaluating anthropometry and gestational age at birth show inconsistent results. Typically, p,p´-DDE exposure has been measured during the third trimester and missed the key early pregnancy period. We evaluated the association between p,p´-DDE exposure before week 18 of pregnancy and anthropometry at birth, as well as gestational length, in 170 mother–child pairs from a cohort study in a flower-growing mexican region. Maternal serum p,p´-DDE concentrations were determined by gas chromatography. The associations between p,p´-DDE and z-scores of birth weight, birth length, and gestational age were evaluated by linear multiple regression models. Logistic regression models were used for low birth weight and small size for gestational age. Effect modification by child’s sex was explored. The average gestational age at the blood sample extraction was 10.6 weeks. p,p'-DDE was detected in 64.7% of mothers, at a geometric mean of 0.24 ng/mL. Prenatal p,p´-DDE exposure was not associated with the birth outcomes in the whole sample. However, a high p,p´-DDE exposure was marginally associated with greater small for gestational age risk in male newborns (OR≥0.076 ng/mL vs <0.076 ng/mL = 3.09, 95% CI: 0.61; 15.58), but not in female (p for interaction = 0.08).
Even though, we found no reductions in anthropometric measurements or gestational length associated with early prenatal p,p´-DDE exposure, the potential effect modification by infant’s sex in terms of small for the gestational age risk deserves future studies.
- Type
- Original Article
- Information
- Journal of Developmental Origins of Health and Disease , Volume 14 , Issue 1 , February 2023 , pp. 15 - 23
- Copyright
- © The Author(s), 2022. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease
References
Barker, DJ, Osmond, C. Low birth weight and hypertension. BMJ. 1988; 297(6641), 134–135.CrossRefGoogle ScholarPubMed
Gillman, MW. Developmental origins of health and disease. N Engl J Med. 2005; 353(17), 1848–1850. DOI 10.1056/NEJMe058187.CrossRefGoogle ScholarPubMed
World Health Organization. Promoting optimal fetal development. In Report of a Technical Consultation, 2006. WHO Press, Geneva.Google Scholar
LaRocca, J, Binder, AM, McElrath, TF, Michels, KB. The impact of first trimester phthalate and phenol exposure on IGF2/H19 genomic imprinting and birth outcomes. Environ Res. 2014; 133(4), 396–406. DOI 10.1016/j.envres.2014.04.032.CrossRefGoogle ScholarPubMed
Torres-Sanchez, L, Zepeda, M, Cebrián, ME, et al. Dichlorodiphenyldichloroethylene exposure during the first trimester of pregnancy alters the anal position in male infants. Ann N Y Acad Sci. 2008; 1140(1), 155–162. DOI 10.1196/annals.1454.004.CrossRefGoogle ScholarPubMed
Hernández-Mariano, JÁ., Torres-Sánchez, L, Bassol-Mayagoitia, S, et al. Effect of exposure to p,p´-DDE during the first half of pregnancy in the maternal thyroid profile of female residents in a Mexican floriculture area. Environ Res. 2017; 156(20), 597–604. DOI 10.1016/j.envres.2017.04.013.CrossRefGoogle Scholar
Watkins, DJ, Milewski, S, Domino, SE, Meeker, JD, Padmanabhan, V. Maternal phthalate exposure during early pregnancy and at delivery in relation to gestational age and size at birth: a preliminary analysis. Reprod Toxicol. 2016; 65(1), 59–66. DOI 10.1016/j.reprotox.2016.06.021.CrossRefGoogle ScholarPubMed
Kezios, KL, Liu, X, Cirillo, PM, et al. Dichlorodiphenyltrichloroethane (DDT), DDT metabolites and pregnancy outcomes. Reprod Toxicol. 2013; 35, 156–164. DOI 10.1016/j.reprotox.2012.10.013.CrossRefGoogle ScholarPubMed
Arrebola, JP, Cuellar, M, Bonde, JP, González-Alzaga, B, Mercado, LA. Associations of maternal o,p'-DDT and p,p'-DDE levels with birth outcomes in a Bolivian cohort. Environ Res. 2016; 151, 469–477. DOI 10.1016/j.envres.2016.08.008.CrossRefGoogle Scholar
Casas, M, Nieuwenhuijsen, M, Martínez, D, et al. Prenatal exposure to PCB-153, p,p'-DDE and birth outcomes in 9000 mother-child pairs: exposure-response relationship and effect modifiers. Environ Int. 2015; 74, 23–31. DOI 10.1016/j.envint.2014.09.013.CrossRefGoogle ScholarPubMed
Jusko, TA, Koepsell, TD, Baker, RJ, et al. Maternal DDT exposures in relation to fetal and 5-year growth. Epidemiology. 2006; 17(6), 692–700. DOI 10.1097/01.ede.0000232226.06807.90.CrossRefGoogle ScholarPubMed
Govarts, E, Iszatt, N, Trnovec, T, et al. Prenatal exposure to endocrine disrupting chemicals and risk of being born small for gestational age: pooled analysis of seven European birth cohorts. Environ Int. 2018; 115, 267–278. DOI 10.1016/j.envint.2018.03.017.CrossRefGoogle ScholarPubMed
Farhang, L, Weintraub, JM, Petreas, M, Eskenazi, B, Bhatia, R. Association of DDT and DDE with birth weight and length of gestation in the child health and development studies, 1959-1967. Am J Epidemiol. 2005; 162(8), 717–725. DOI 10.1093/aje/kwi276.CrossRefGoogle ScholarPubMed
Wolff, MS, Engel, S, Berkowitz, G, et al. Prenatal pesticide and PCB exposures and birth outcomes. Pediatr Res. 2007; 61(2), 243–250. DOI 10.1203/pdr.0b013e31802d77f0.CrossRefGoogle ScholarPubMed
Guo, H, Jin, Y, Cheng, Y, et al. Prenatal exposure to organochlorine pesticides and infant birth weight in China. Chemosphere. 2014; 110, 1–7. DOI 10.1016/j.chemosphere.2014.02.017.CrossRefGoogle ScholarPubMed
Longnecker, MP, Klebanoff, MA, Zhou, H, Brock, JW. Association between maternal serum concentration of the DDT metabolite DDE and preterm and small-for-gestational-age babies at birth. Lancet. 2001; 358(9276), 110–114. DOI 10.1016/S0140-6736(01)05329-6.CrossRefGoogle ScholarPubMed
Siddiqui, MK, Srivastava, S, Srivastava, SP, Mehrotra, PK, Mathur, N, Tandon, I. Persistent chlorinated pesticides and intra-uterine foetal growth retardation: a possible association. Int Arch Occup Environ Health. 2003; 76(1), 75–80. DOI 10.1007/s00420-002-0393-6.CrossRefGoogle ScholarPubMed
Ribas-Fito, N, Sala, M, Cardo, E, et al. Association of hexachlorobenzene and other organochlorine compounds with anthropometric measures at birth. Pediatr Res. 2002; 52(2), 163–167. DOI 10.1203/00006450-200208000-00006.CrossRefGoogle ScholarPubMed
Chevrier, J, Rauch, S, Crause, M, et al. Associations of maternal exposure to dichlorodiphenyltrichloroethane and pyrethroids with birth outcomes among participants in the venda health examination of mothers, babies and their environment residing in an area sprayed for malaria control. Am J Epidemiol. 2019; 188(1), 130–140. DOI 10.1093/aje/kwy143.CrossRefGoogle Scholar
Cupul-Uicab, LA, Hernández-Avila, M, Terrazas-Medina, EA, Pennell, ML, Longnecker, MP. Prenatal exposure to the major DDT metabolite 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and growth in boys from Mexico. Environ Res. 2010; 110(6), 595–603. DOI 10.1016/j.envres.2010.06.001.CrossRefGoogle Scholar
Wang, RY, Jain, RB, Wolkin, AF, Rubin, CH, Needham, LL. Serum concentrations of selected persistent organic pollutants in a sample of pregnant females and changes in their concentrations during gestation. Environ Health Perspect. 2009; 117(8), 1244–1249. DOI 10.1289/ehp.0800105.CrossRefGoogle Scholar
Robledo, CA, Yeung, E, Mendola, P, et al. Preconception maternal and paternal exposure to persistent organic pollutants and birth size: the LIFE study. Environ Health Perspect. 2015; 123(1), 88–94. DOI 10.1289/ehp.1308016.CrossRefGoogle ScholarPubMed
Yáñez, L, Ortiz-Pérez, D, Batres, LE, Borja-Aburto, VH, Díaz-Barriga, F. Levels of dichlorodiphenyltrichloroethane and deltamethrin in humans and environmental samples in malarious areas of Mexico. Environ Res. 2002; 88(3), 174–181. DOI 10.1006/enrs.2002.4333.CrossRefGoogle ScholarPubMed
Trejo Acevedo, A, Rivero Pérez, NE, Flores, RR, Varela Silva, JA, Pérez Maldonado, IN. Assessment of the levels of persistent organic pollutants and 1-hydroxypyrene in blood and urine samples from Mexican. Bull Environ Contam Toxicol. 2012; 88(6), 828–832. DOI 10.1007/s00128-012-0593-z.CrossRefGoogle ScholarPubMed
Waliszewski, SM, Sanchez, K, Caba, M, et al. Organochlorine pesticide levels in female adipose tissue from Puebla, Mexico. Bull Environ Contam Toxicol. 2012; 88(2), 296–301. DOI 10.1007/s00128-011-0438-1.CrossRefGoogle ScholarPubMed
Alvarado-Hernandez, DL, Montero-Montoya, R, Serrano-García, L, Arellano-Aguilar, O, Jasso-Pineda, Y, Yáñez-Estrada, L. Assessment of exposure to organochlorine pesticides and levels of DNA damage in mother-infant pairs of an agrarian community. Environ Mol Mutagen. 2013; 54(2), 99–111. DOI 10.1002/em.21753.CrossRefGoogle ScholarPubMed
Garced, S, Torres-Sánchez, L, Cebrián, ME, Claudio, L, López-Carrillo, L. Prenatal dichlorodiphenyldichloroethylene (DDE) exposure and child growth during the first year of life. Environ Res. 2012; 113, 58–62. DOI 10.1016/j.envres.2011.12.002.CrossRefGoogle ScholarPubMed
Meakin, AS, Saif, Z, Tuck, AR, Clifton, VL. Human placental androgen receptor variants: potential regulators of male fetal growth. Placenta. 2019; 80(5), 18–26. DOI 10.1016/j.placenta.2019.03.012.CrossRefGoogle ScholarPubMed
US Environmental Protection Agency. Manual of Analytical Methods for the Analysis of Pesticides in Humans and Environmental Samples, 1980. US Environmental Protection Agency, Washington, DC.Google Scholar
US Environmental Protection Agency. Assigning values to non-detected/non-quantified pesticide residues in human health food exposure assessments. In Office of Pesticide Programs, March 23, 2000; pp. 20460. U.S. Environmental Protection Agency, Washington, DC.Google Scholar
Villar, J, Cheikh Ismail, L, Victora, CG, et al. International standards for newborn weight, length, and head circumference by gestational age and sex: the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project. Lancet. 2014; 384(9946), 857–868. DOI 10.1016/S0140-6736(14)60932-6.CrossRefGoogle ScholarPubMed
Fang, J, Liu, H, Zhao, H, Wong, M, Xu, S, Cai, Z. Association of prenatal exposure to organochlorine pesticides and birth size. Sci Total Environ. 2019; 654(1–7), 678–683. DOI 10.1016/j.scitotenv.2018.10.384.CrossRefGoogle ScholarPubMed
Kamai, EM, McElrath, TF, Ferguson, KK. Fetal growth in environmental epidemiology: mechanisms, limitations, and a review of associations with biomarkers of non-persistent chemical exposures during pregnancy. Environ Health. 2019; 18(1), 43. DOI 10.1186/s12940-019-0480-8.CrossRefGoogle Scholar
Callan, AC, Hinwood, AL, Heyworth, J, Phi, DT, Odland, JØ. Sex specific influence on the relationship between maternal exposures to persistent chemicals and birth outcomes. Int J Hyg Environ Health. 2016; 219(8), 734–741. DOI 10.1016/j.ijheh.2016.09.018.CrossRefGoogle ScholarPubMed
de Cock, M, De Boer, MR, Lamoree, M, Legler, J, Van De Bor, M. Prenatal exposure to endocrine disrupting chemicals and birth weight-A prospective cohort study. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2016; 51(2), 178–185. DOI 10.1080/10934529.2015.1087753.CrossRefGoogle ScholarPubMed
Maccoby, EE, Doering, CH, Jacklin, CN, Kraemer, H. Concentrations of sex hormones in umbilical-cord blood: their relation to sex and birth order of infants. Child Dev. 1979; 50(3), 632–642.CrossRefGoogle ScholarPubMed
UNICEF. The State of the World’s Children 2019. Children, Food and Nutrition: Growing Well in a Changing World, 2019. UNICEF, New York.Google Scholar
de Castro, F, Allen-Leigh, B, Katz, G, Salvador-Carulla, L, Lazcano-Ponce, E. Child wellbeing and development indicators in Mexico. Salud Publica Mex. 2013; 55(Suppl 2), S267–S275.Google ScholarPubMed
Lazcano-Ponce, E, Reynales-Shigematsu, LM, Guerrero-López, CM, et al. Encuesta Nacional de Adicciones 2011: Tabaco, 2013. Instituto Nacional de Salud Pública, Cuernavaca, México.Google Scholar
Uribe-Leitz, T, Barrero-Castillero, A, Cervantes-Trejo, A, et al. Trends of caesarean delivery from 2008 to 2017. Mexico Bull World Health Organ. 2019; 97(7), 502–512. DOI 10.2471/BLT.18.224303.CrossRefGoogle ScholarPubMed
Mook-Kanamori, DO, Steegers, EA, Eilers, PH, Raat, H, Hofman, A, Jaddoe, VW. Risk factors and outcomes associated with first-trimester fetal growth restriction. JAMA. 2010; 303(6), 527–534. DOI 10.1001/jama.2010.78.CrossRefGoogle ScholarPubMed
Burton, GJ, Yung, HW, Cindrova-Davies, T, Charnock-Jones, DS. Placental endoplasmic reticulum stress and oxidative stress in the pathophysiology of unexplained intrauterine growth restriction and early onset preeclampsia. Placenta. 2009; 30(Suppl A), S43–S48. DOI 10.1016/j.placenta.2008.11.003.CrossRefGoogle ScholarPubMed
Moreno-Banda, G, Blanco-Muñoz, J, Lacasaña, M, et al. Maternal exposure to floricultural work during pregnancy, PON1 Q192R polymorphisms and the risk of low birth weight. Sci Total Environ. 2009; 407(21), 5478–5485. DOI 10.1016/j.scitotenv.2009.06.033.CrossRefGoogle ScholarPubMed
Lange, S, Shield, K, Koren, G, Rehm, J, Popova, S. A comparison of the prevalence of prenatal alcohol exposure obtained via maternal self-reports versus meconium testing: a systematic literature review and meta-analysis. BMC Pregnancy Childbirth. 2014; 14(1), 127. DOI 10.1186/1471-2393-14-127.CrossRefGoogle ScholarPubMed
Tong, VT, Althabe, F, Alemán, A, et al. Accuracy of self-reported smoking cessation during pregnancy. Acta Obstet Gynecol Scand. 2015; 94(1), 106–111. DOI 10.1111/aogs.12532.CrossRefGoogle ScholarPubMed
Lenters, V, Portengen, L, Rignell-Hydbom, A, et al. Prenatal phthalate, perfluoroalkyl acid, and organochlorine exposures and term birth weight in three birth cohorts: multi-pollutant models based on elastic net regression. Environ Health Perspect. 2016; 124(3), 365–372. DOI 10.1289/ehp.1408933.CrossRefGoogle ScholarPubMed
Torres-Sánchez et al. supplementary material
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