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Limosilactobacillus fermentum prevents gut-kidney oxidative damage and the rise in blood pressure in male rat offspring exposed to a maternal high-fat diet

Published online by Cambridge University Press:  19 April 2022

Luciana Caroline Paulino do Nascimento ,
Evandro Leite de Souza ,
Micaelle Oliveira de Luna Freire ,
Valdir de Andrade Braga ,
Thatyane Mariano Rodrigues de Albuqeurque ,
Cláudia Jacques Lagranha  and
José Luiz de Brito Alves Open the ORCID record for José Luiz de Brito Alves [Opens in a new window]
Luciana Caroline Paulino do Nascimento
Affiliation:
Department of Nutrition, Health Sciences Center, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
Evandro Leite de Souza
Affiliation:
Department of Nutrition, Health Sciences Center, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
Micaelle Oliveira de Luna Freire
Affiliation:
Department of Biotechnology, Biotechnology Center, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
Valdir de Andrade Braga
Affiliation:
Department of Biotechnology, Biotechnology Center, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
Thatyane Mariano Rodrigues de Albuqeurque
Affiliation:
Department of Nutrition, Health Sciences Center, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
Cláudia Jacques Lagranha
Affiliation:
Laboraroty of Biochemistry and Exercise Biochemistry, Federal University of Pernambuco, Vitória DE Santo Antão, Pernambuco, Brazil
José Luiz de Brito Alves*
Affiliation:
Department of Nutrition, Health Sciences Center, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
*
Address for correspondence: José Luiz DE Brito Alves, Federal University of Paraiba, Department of Nutrition, Campus I – Jd, Cidade Universitária, CEP: 58051-900, João Pessoa, PB, Brazil. Emails: jose_luiz_61@hotmail.com; jose.luiz@academico.ufpb.br.
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Abstract

Oxidative stress along the gut-kidney axis is a risk factor for developing arterial hypertension in offspring from dams fed a high-fat diet. Considering the antioxidant capacity of probiotic strains, this study evaluated the effects of a daily multistrain formulation with Limosilactobacillus fermentum 139, 263, and 296 on blood pressure (BP), renal function, and oxidative stress and along the gut-kidney axis in male offspring from dams fed a high-fat high-cholesterol (HFHC) diet during pregnancy and lactation. Dams were fed a diet control or HFHC diet during pregnancy and lactation. At 100 days of age, part of the male offspring from dams fed a HFHC diet received Limosilactobacillus fermentum formulation for 4 weeks (HFHC + Lf) daily. After the 4-week intervention, BP (tail-cuff plethysmography) and urinary and biochemical variables were measured. In addition, malondialdehyde levels, enzymatic activities of superoxide dismutase, catalase, glutathione-S-transferase, and nonenzymatic antioxidant defense (thiols content) were measured in the colon and renal cortex. Male offspring from dams fed a HFHC had increased blood pressure, impaired renal function, and oxidative stress along the gut-kidney axis. Administration of Limosilactobacillus fermentum reduced systolic, diastolic, and mean blood pressure levels and alleviated renal function impairment and oxidative stress along the gut-kidney axis in male offspring from dams fed a HFHC diet. Administration of Limosilactobacillus fermentum formulation attenuated programmed hypertension in the HFHC group through oxidative stress modulation along the gut-kidney axis.

Keywords

High-fat dietLimosilactobacillusprobioticantioxidant capacitygut kidney axishypertension
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 13 , Issue 6 , December 2022 , pp. 719 - 726
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Copyright
© The Author(s), 2022. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease

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