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Maternal and early life factors of tooth emergence patterns and number of teeth at 1 and 2 years of age

  • G. Ntani (a1), P. F. Day (a2), J. Baird (a1), K. M. Godfrey (a1) (a3), S. M. Robinson (a1), C. Cooper (a1), H. M. Inskip (a1) and the Southampton Women’s Survey Study Group...


Various environmental factors have been associated with the timing of eruption of primary dentition, but the evidence to date comes from small studies with limited information on potential risk factors. We aimed to investigate associations between tooth emergence patterns and pre-conception, pregnancy and postnatal influences. Dentition patterns were recorded at ages 1 and 2 years in 2915 children born to women in the Southampton Women’s Survey from whom information had been collected on maternal factors before conception and during pregnancy. In mutually adjusted regression models we found that: children were more dentally advanced at ages 1 and 2 years if their mothers had smoked during pregnancy or they were longer at birth; mothers of children whose dental development was advanced at age 2 years tended to have poorer socioeconomic circumstances, and to have reported a slower walking speed pre-pregnancy; and children of mothers of Asian ethnicity had later tooth development than those of white mothers. The findings add to the evidence of environmental impacts on the timing of the eruption of primary dentition in indicating that maternal smoking during pregnancy, socio-economic status and physical activity (assessed by reported walking speed) may influence the child’s primary dentition. Early life factors, including size at birth are also associated with dentition patterns, as is maternal ethnicity.


Corresponding author

*Address for correspondence: G. Ntani, MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, SO16 6YD, Southampton, UK. (Email


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H.M.I. and C.C. are joint last authors.



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1. Koussoulakou, DS, Margaritis, LH, Koussoulakos, SL. A curriculum vitae of teeth: evolution, generation, regeneration. Int J Biol Sci. 2009; 5, 226243.
2. Nanci, A. Ten Cate’s Oral Histology: Development, Structure, and Function, 8th edn, 2012. Elsevier Science Health Science Division: USA.
3. Hughes, TE, Bockmann, MR, Seow, K, et al. Strong genetic control of emergence of human primary incisors. J Dent Res. 2007; 86, 11601165.
4. Pillas, D, Hoggart, CJ, Evans, DM, et al. Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. PLoS Genet. 2010; 6, e1000856.
5. Barker, DJP. Mothers, Babies and Disease in Later Life. 1994. BMJ Publishing Group: London.
6. Ku, D, Ben-Shlomo, Y. A Life Course Approach to Chronic Disease Epidemiology. 1997. Oxford University Press: New York.
7. Bastos, JL, Peres, MA, Peres, KG, Barros, AJ. Infant growth, development and tooth emergence patterns: a longitudinal study from birth to 6 years of age. Arch Oral Biol. 2007; 52, 598606.
8. Rantakallio, P, Makinen, H. The effect of maternal smoking on the timing of deciduous tooth eruption. Growth. 1983; 47, 122128.
9. Rantakallio, P, Makinen, H. Number of teeth at the age of one year in relation to maternal smoking. Ann Hum Biol. 1984; 11, 4552.
10. Psoter, W, Gebrian, B, Prophete, S, Reid, B, Katz, R. Effect of early childhood malnutrition on tooth eruption in Haitian adolescents. Community Dent Oral Epidemiol. 2008; 36, 179189.
11. Al-Jasser, NM, Bello, LL. Time of eruption of primary dentition in Saudi children. J Contemp Dent Pract. 2003; 4, 6575.
12. Townsend, N, Hammel, EA. Age estimation from the number of teeth erupted in young children: an aid to demographic surveys. Demography. 1990; 27, 165174.
13. Inskip, HM, Godfrey, KM, Robinson, SM, et al. Cohort profile: the Southampton Women’s Survey. Int J Epidemiol. 2006; 35, 4248.
14. Syddall, HE, Westbury, LD, Cooper, C, Sayer, AA. Self-reported walking speed: a useful marker of physical performance among community-dwelling older people? J Am Med Dir Assoc . 2014; doi:10.1016/j.jamda.2014.11.004 (Epub ahead of print).
15. Robinson, S, Godfrey, K, Osmond, C, Cox, V, Barker, D. Evaluation of a food frequency questionnaire used to assess nutrient intakes in pregnant women. Eur J Clin Nutr. 1996; 50, 302308.
16. Robinson, SM, Crozier, SR, Borland, SE, et al. Impact of educational attainment on the quality of young women’s diets. Eur J Clin Nutr. 2004; 58, 11741180.
17. Haddad, AE, Correa, MS. The relationship between the number of erupted primary teeth and the child's height and weight: a cross-sectional study. J Clin Pediatr Dent. 2005; 29, 357362.
18. Royston, P, Parmar, MK. Flexible parametric proportional‐hazards and proportional‐odds models for censored survival data, with application to prognostic modelling and estimation of treatment effects. Stat Med. 2002; 21, 21752197.
19. StataCorp. Stata Statistical Software: Release 13. 2013. TSL: College Station, TX.
20. Macera, CA, Powell, KE. Population attributable risk: implications of physical activity dose. Med Sci Sports Exerc. 2001; 33(Suppl.), S635S639, discussion 40–41.
21. Falkner, F. Deciduous tooth eruption. Arch Dis Child. 1957; 32, 386391.
22. Hagg, U, Taranger, J. Timing of tooth emergence. A prospective longitudinal study of Swedish urban children from birth to 18 years. Swed Dent J. 1986; 10, 195206.
23. Hitchcock, NE, Gilmour, AI, Gracey, M, Kailis, DG. Australian longitudinal study of time and order of eruption of primary teeth. Community Dent Oral Epidemiol. 1984; 12, 260263.
24. Godfrey, K, Walker-Bone, K, Robinson, S, et al. Neonatal bone mass: influence of parental birthweight, maternal smoking, body composition, and activity during pregnancy. J Bone Miner Res. 2001; 16, 16941703.
25. Pfeiffer, CM, Sternberg, MR, Schleicher, RL, Rybak, ME. Dietary supplement use and smoking are important correlates of biomarkers of water-soluble vitamin status after adjusting for sociodemographic and lifestyle variables in a representative sample of U.S. adults. J Nutr. 2013; 143, 957s965s.
26. Lin, FJ, Fitzpatrick, JW, Iannotti, CA, et al. Effects of cadmium on trophoblast calcium transport. Placenta. 1997; 18, 341356.
27. Billewicz, WZ, Thomson, AM, Baber, FM, Field, CE. The development of primary teeth in Chinese (Hong Kong) children. Hum Biol. 1973; 45, 229241.
28. Holman, DJ, Yamaguchi, K. Longitudinal analysis of deciduous tooth emergence: IV. Covariate effects in Japanese children. Am J Phys Anthropol. 2005; 126, 352358.
29. Sajjadian, N, Shajari, H, Jahadi, R, Barakat, MG, Sajjadian, A. Relationship between birth weight and time of first deciduous tooth eruption in 143 consecutively born infants. Pediatr Neonatol. 2010; 51, 235237.
30. Seow, WK, Humphrys, C, Mahanonda, R, Tudehope, DI. Dental eruption in low birth-weight prematurely born children: a controlled study. Pediatr Dent. 1988; 10, 3942.
31. Aktoren, O, Tuna, EB, Guven, Y, Gokcay, G. A study on neonatal factors and eruption time of primary teeth. Community Dent Health. 2010; 27, 5256.
32. Ramos, SR, Gugisch, RC, Fraiz, FC. The influence of gestational age and birth weight of the newborn on tooth eruption. J Appl Oral Sci. 2006; 14, 228232.
33. Golden, NL, Takieddine, F, Hirsch, VJ. Teething age in prematurely born infants. Am J Dis Child. 1981; 135, 903904.
34. Viscardi, RM, Romberg, E, Abrams, RG. Delayed primary tooth eruption in premature infants: relationship to neonatal factors. Pediatr Dent. 1994; 16, 2328.
35. Delgado, H, Habicht, JP, Yarbrough, C, et al. Nutritional status and the timing of deciduous tooth eruption. Am J Clin Nutr. 1975; 28, 216224.
36. Sanchez-Perez, L, Irigoyen, ME, Zepeda, M. Dental caries, tooth eruption timing and obesity: a longitudinal study in a group of Mexican schoolchildren. Acta Odontol Scand. 2010; 68, 5764.
37. Soliman, NL, El-Zainy, MA, Hassan, RM, Aly, RM. Relationship of deciduous teeth emergence with physical growth. Indian J Dent Res. 2012; 23, 236240.
38. Infante, PF, Owen, GM. Relation of chronology of deciduous tooth emergence to height, weight and head circumference in children. Arch Oral Biol. 1973; 18, 14111417.
39. Oziegbe, EO, Adekoya-Sofowora, C, Folayan, MO, Esan, TA, Owotade, FJ. Relationship between socio-demographic and anthropometric variables and number of erupted primary teeth in suburban Nigerian children. Matern Child Nutr. 2009; 5, 8692.
40. Ounsted, M, Moar, V, Scott, A. A longitudinal study of tooth emergence and somatic growth in 697 children from birth to three years. Arch Oral Biol. 1987; 32, 787791.
41. Singh, N, Sharma, S, Sikri, V, Singh, P. To study the average age of eruption of primary dentition in Amritsar and surrounding area. Jewelry Industry Distributors Association. 2000; 71, 26.
42. Bambach, M, Saracci, R, Young, HB. Emergence of deciduous teeth in Tunisian children in relation to sex and social class. Hum Biol. 1973; 45, 435444.
43. Caufield, PW, Li, Y, Bromage, TG. Hypoplasia-associated severe early childhood caries – a proposed definition. J Dent Res. 2012; 91, 544550.
44. Ismail, AI, Lim, S, Sohn, W, Willem, JM. Determinants of early childhood caries in low-income African American young children. Pediatr Dent. 2008; 30, 289296.
45. Milgrom, P, Riedy, CA, Weinstein, P, et al. Dental caries and its relationship to bacterial infection, hypoplasia, diet, and oral hygiene in 6- to 36-month-old children. Community Dent Oral Epidemiol. 2000; 28, 295306.



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