1.Guh, DP, Zhang, W, Bansback, N, Amarsi, Z, Birmingham, CL, Anis, AH. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health. 2009; 9, 88.
2.Abete, I, Navas-Carretero, S, Marti, A, Martinez, JA. Nutrigenetics and nutrigenomics of caloric restriction. Prog Mol Biol Transl Sci. 2012; 108, 323–346.
3.Martinez, JA, Cordero, P, Campion, J, Milagro, FI. Interplay of early-life nutritional programming on obesity, inflammation and epigenetic outcomes. Proc Nutr Soc. 2012; 71, 276–283.
4.Zou, M, Arentson, EJ, Teegarden, D, Koser, SL, Onyskow, L, Donkin, SS. Fructose consumption during pregnancy and lactation induces fatty liver and glucose intolerance in rats. Nutr Res. 2012; 32, 588–598.
5.Blackmore, HL, Ozanne, SE. Maternal diet-induced obesity and offspring cardiovascular health. J Dev Orig Health Dis. 2013; 4, 338–347.
6.Roseboom, T, de Rooij, S, Painter, R. The Dutch famine and its long-term consequences for adult health. Early Hum Dev. 2006; 82, 485–491.
7.Ohlsson, A, Shah, PS. Effects of the September 11, 2001 disaster on pregnancy outcomes: a systematic review. Acta Obstet Gynecol Scand. 2011; 90, 6–18.
8.Behl, M, Rao, D, Aagaard, K, et al. Evaluation of the association between maternal smoking, childhood obesity, and metabolic disorders: a national toxicology program workshop review. Environ Health Perspect. 2013; 121, 170–180.
9.Vucetic, Z, Kimmel, J, Totoki, K, Hollenbeck, E, Reyes, TM. Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes. Endocrinology. 2010; 151, 4756–4764.
10.Waterland, RA, Travisano, M, Tahiliani, KG, Rached, MT, Mirza, S. Methyl donor supplementation prevents transgenerational amplification of obesity. Int J Obes (Lond). 2008; 32, 1373–1379.
11.Lillycrop, KA, Phillips, ES, Jackson, AA, Hanson, MA, Burdge, GC. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr. 2005; 135, 1382–1386.
12.Szeto, IM, Das, PJ, Aziz, A, Anderson, GH. Multivitamin supplementation of Wistar rats during pregnancy accelerates the development of obesity in offspring fed an obesogenic diet. Int J Obes (Lond). 2009; 33, 364–372.
13.Cordero, P, Campion, J, Milagro, FI, Martinez, JA. Dietary supplementation with methyl donor groups could prevent nonalcoholic fatty liver. Hepatology. 2011; 53, 2151–2152.
14.Cordero, P, Gomez-Uriz, AM, Campion, J, Milagro, FI, Martinez, JA. Dietary supplementation with methyl donors reduces fatty liver and modifies the fatty acid synthase DNA methylation profile in rats fed an obesogenic diet. Genes Nutr. 2013; 8, 105–113.
15.Ding, Y, He, J, Liu, X, Chen, X, Long, C, Wang, Y. Expression of DNA methyltransferases in the mouse uterus during early pregnancy and susceptibility to dietary folate deficiency. Reproduction. 2012; 144, 91–100.
16.Cordero, P, Campion, J, Milagro, FI, Martinez, JA. Transcriptomic and epigenetic changes in early liver steatosis associated to obesity: effect of dietary methyl donor supplementation. Mol Genet Metab. 2013; 110, 388–395.
17.Cordero, P, Gomez-Uriz, AM, Milagro, FI, Campion, J, Martinez, JA. Maternal weight gain induced by an obesogenic diet affects adipose accumulation, liver weight, and insulin homeostasis in the rat offspring depending on the sex. J Endocrinol Invest. 2012; 35, 981–986.
18.Faust, IM, Johnson, PR, Hirsch, J. Long-term effects of early nutritional experience on the development of obesity in the rat. J Nutr. 1980; 110, 2027–2034.
19.Nixon, JP, Zhang, M, Wang, C, et al.Evaluation of a quantitative magnetic resonance imaging system for whole body composition analysis in rodents. Obesity (Silver Spring). 2010; 18, 1652–1659.
20.Friedewald, WT, Levy, RI, Fredrickson, DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972; 18, 499–502.
21.Desjardins, P, Conklin, D. NanoDrop microvolume quantitation of nucleic acids. J Vis Exp. 2010; 45, e2562.
22.Livak, KJ, Schmittgen, TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001; 25, 402–408.
23.Paternain, L, de la Garza, AL, Batlle, MA, Milagro, FI, Martinez, JA, Campion, J. Prenatal stress increases the obesogenic effects of a high-fat-sucrose diet in adult rats in a sex-specific manner. Stress. 2013; 16, 220–232.
24.Kovacheva, VP, Mellott, TJ, Davison, JM, et al.Gestational choline deficiency causes global and Igf2 gene DNA hypermethylation by up-regulation of Dnmt1 expression. J Biol Chem. 2007; 282, 31777–31788.
25.Hebbard, L, George, J. Animal models of nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol. 2011; 8, 35–44.
26.Starlard-Davenport, A, Tryndyak, V, Kosyk, O, et al.Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis. J Nutrigenet Nutrigenomics. 2010; 3, 259–266.
27.Khan, IY, Dekou, V, Douglas, G, et al. A high-fat diet during rat pregnancy or suckling induces cardiovascular dysfunction in adult offspring. Am J Physiol Regul Integr Comp Physiol. 2005; 288, 127–133.
28.Flynn, ER, Alexander, BT, Lee, J, Hutchens, ZM Jr., Maric-Bilkan, C. High-fat/fructose feeding during prenatal and postnatal development in female rats increases susceptibility to renal and metabolic injury later in life. Am J Physiol Regul Integr Comp Physiol. 2013; 304, 278–285.
29.Alzamendi, A, Castrogiovanni, D, Gaillard, RC, Spinedi, E, Giovambattista, A. Increased male offspring’s risk of metabolic-neuroendocrine dysfunction and overweight after fructose-rich diet intake by the lactating mother. Endocrinology. 2010; 151, 4214–4223.
30.Palou, M, Priego, T, Sanchez, J, Torrens, JM, Palou, A, Pico, C. Moderate caloric restriction in lactating rats protects offspring against obesity and insulin resistance in later life. Endocrinology. 2010; 151, 1030–1041.
31.United States Department of Agriculture (USDA). National nutrient database for standard reference. Retrieved 10 June 2014 from http://ndb.nal.usda.gov
32.Perseghin, G. Lipids in the wrong place: visceral fat and nonalcoholic steatohepatitis. Diabetes Care. 2011; 34, S367–S370.
33.Fabbrini, E, Magkos, F, Mohammed, BS, et al. Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc Natl Acad Sci U S A. 2009; 106, 15430–15435.
34.Pooya, S, Blaise, S, Moreno Garcia, M, et al. Methyl donor deficiency impairs fatty acid oxidation through PGC-1α hypomethylation and decreased ER-α, ERR-α, and HNF-4α in the rat liver. J Hepatol. 2012; 57, 344–351.
35.Huang, Y, He, Y, Sun, X, He, Y, Li, Y, Sun, C. Maternal high folic acid supplement promotes glucose intolerance and insulin resistance in male mouse offspring fed a high-fat diet. Int J Mol Sci. 2014; 15, 6298–6313.
36.Wells, JC. The thrifty phenotype as an adaptive maternal effect. Biol Rev Camb Philos Soc. 2007; 82, 143–172.
37.Koo, SH. Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis. Clin Mol Hepatol. 2013; 19, 210–215.
38.D’Alessandro, ME, Oliva, ME, Fortino, MA, Chicco, A. Maternal sucrose-rich diet and fetal programming: changes in hepatic lipogenic and oxidative enzymes and glucose homeostasis in adult offspring. Food Funct. 2014; 5, 446–453.
39.Speakman, J, Hambly, C, Mitchell, S, Król, E. Animal models of obesity. Obes Rev. 2007; 1, 55–61.
40.Ojeda, ML, Delgado-Villa, MJ, Llopis, R, Murillo, ML, Carreras, O. Lipid metabolism in ethanol-treated rat pups and adults: effects of folic acid. Alcohol Alcohol. 2008; 43, 544–550.
41.Aragno, M, Tomasinelli, CE, Vercellinatto, I, et al. SREBP-1c in nonalcoholic fatty liver disease induced by western-type high-fat diet plus fructose in rats. Free Radic Biol Med. 2009; 47, 1067–1074.
42.Strable, MS, Ntambi, JM. Genetic control of de novo lipogenesis: role in diet-induced obesity. Crit Rev Biochem Mol Biol. 2010; 45, 199–214.
43.Oliveira, LP, de Jesús, RP, Freire, TO, Oliveira, CP, Castro Lyra, A, Lyra, LG. Possible molecular mechanisms soy-mediated in preventing and treating nonalcoholic fatty liver disease. Nutr Hosp. 2012; 27, 991–998.
44.Majumder, S, Ghoshal, K, Datta, J, et al. Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma. J Biol Chem. 2002; 277, 16048–16058.
45.Jurkowska, RZ, Jurkowski, TP, Jeltsch, A. Structure and function of mammalian DNA methyltransferases. Chembiochem. 2011; 12, 206–222.
46.Gong, L, Pan, YX, Chen, H. Gestational low protein diet in the rat mediates Igf2 gene expression in male offspring via altered hepatic DNA methylation. Epigenetics. 2010; 5, 619–626.
47.Starley, BQ, Calcagno, CJ, Harrison, SA. Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection. Hepatology. 2010; 51, 1820–1832.
48.Kamei, Y, Suganami, T, Ehara, T, et al. Increased expression of DNA methyltransferase 3a in obese adipose tissue: studies with transgenic mice. Obesity (Silver Spring). 2010; 18, 314–321.
49.Lu, H, Cui, JY, Gunewardena, S, Yoo, B, Zhong, XB, Klaassen, CD. Hepatic ontogeny and tissue distribution of mRNAs of epigenetic modifiers in mice using RNA-sequencing. Epigenetics. 2012; 7, 914–929.
50.Cordero, P, Milagro, FI, Campion, J, Martinez, JA. Maternal methyl donors supplementation during lactation prevents the hyperhomocysteinemia induced by a high-fat-sucrose intake by dams. Int J Mol Sci. 2013; 14, 24422–24437.
51.Panchal, SK, Brown, L. Rodent models for metabolic syndrome research. J Biomed Biotechnol. 2011; 2011, 351982.
52.Garcia, AP, Palou, M, Priego, T, Sanchez, J, Palou, A, Pico, C. Moderate caloric restriction during gestation results in lower arcuate nucleus NPY- and alphaMSH-neurons and impairs hypothalamic response to fed/fasting conditions in weaned rats. Diabetes Obes Metab. 2010; 12, 403–413.
53.Gomez-Ruiz, A, Milagro, FI, Campion, J, Martinez, JA, de Miguel, C. High-fat diet feeding alters metabolic response to fasting/non fasting conditions. Effect on caveolin expression and insulin signalling. Lipids Health Dis.. 2011; 10, 55.
54.Tsuchiya, H, Ikeda, Y, Ebata, Y, et al. Retinoids ameliorate insulin resistance in a leptin-dependent manner in mice. Hepatology. 2012; 56, 1319–1330.
55.Tsiambas, E, Georgiannos, SN, Salemis, N, et al. Significance of estrogen receptor 1 (ESR-1) gene imbalances in colon and hepatocellular carcinomas based on tissue microarrays analysis. Med Oncol. 2011; 28, 934–940.
56.Byrne, JA, Meara, NJ, Rayner, AC, Thompson, RJ, Knisely, AS. Lack of hepatocellular CD10 along bile canaliculi is physiologic in early childhood and persistent in Alagille syndrome. Lab Invest. 2007; 87, 1138–1148.