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Teratogenic effects of Bocconia frutescens L.

Published online by Cambridge University Press:  07 January 2020

L. S. Lunagómez ,
I. Santiago-Roque ,
Y. A. Gheno-Heredia ,
A. A. Corona-Morales  and
V. E. Bolado-García Open the ORCID record for V. E. Bolado-García [Opens in a new window]
L. S. Lunagómez
Affiliation:
Maestría en Seguridad Alimentaria y Nutricional, Facultad de Nutrición, Universidad Veracruzana, Xalapa, México
I. Santiago-Roque
Affiliation:
Laboratorio de Neurotoxicología, Facultad de Bioanálisis, Universidad Veracruzana, Xalapa, México
Y. A. Gheno-Heredia
Affiliation:
Facultad de Ciencias Biológicas y Agropecuarias, Universidad Veracruzana, Córdoba Veracruz, México
A. A. Corona-Morales
Affiliation:
Laboratorio de Investigación Genómica y Fisiológica, Facultad de Nutrición, Universidad Veracruzana, Xalapa, México
V. E. Bolado-García*
Affiliation:
Laboratorio de Investigación Genómica y Fisiológica, Facultad de Nutrición, Universidad Veracruzana, Xalapa, México
*
Address for correspondence: Victoria Eugenia Bolado-García, Laboratorio de Investigación Genómica y Fisiológica, Facultad de Nutrición, Médicos y odontólogos s/n, Col. Unidad del Bosque, Universidad Veracruzana, Xalapa 91010, México. Email: vbolado@uv.mx
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Abstract

It is estimated that 80% of the world population trusts traditional medicine. A large number of Americans use infusions of Bocconia frutescens L. leaves to treat cough and gastrointestinal disorders. However, phytochemical studies reveal that this plant contains alkaloids and other potentially harmful substances. This study aimed to evaluate the teratogenic effects of B. frutescens L. in an experimental model. Pregnant Wistar rats were administered lyophilized B. frutescens L. extract at 300 mg/kg/day or vehicle by orogastric route during the organogenesis period (gestation days 7–13), and external and internal congenital malformations were analyzed on the progeny on gestational day 20. Bocconia frutescens L. produced a significant increase in the number of different malformations, relative to the control group. We conclude that the consumption of B. frutescens L. during pregnancy at a dose equivalent to that consumed by humans increases the risk of teratogenic effects.

Keywords

Teratogenesismedicinal plantspregnancymalformations
Type
Brief Report
Information
Journal of Developmental Origins of Health and Disease , Volume 11 , Issue 4 , August 2020 , pp. 415 - 418
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2020

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