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Western diet in the perinatal period promotes dysautonomia in the offspring of adult rats

Published online by Cambridge University Press:  09 December 2016

R. Vidal-Santos ,
F. N. Macedo ,
M. N. S. Santana ,
V. U. De Melo ,
J. L. de Brito Alves ,
M. R. V. Santos ,
L. C. Brito ,
E. Nascimento ,
J. H. Costa-Silva  and
V. J. Santana-Filho
R. Vidal-Santos*
Affiliation:
Department of Physiology, Federal University of Sergipe, São Cristovão, Brazil
F. N. Macedo
Affiliation:
Department of Physiology, Federal University of Sergipe, São Cristovão, Brazil
M. N. S. Santana
Affiliation:
Department of Physiology, Federal University of Sergipe, São Cristovão, Brazil
V. U. De Melo
Affiliation:
Department of Physiology, Federal University of Sergipe, São Cristovão, Brazil
J. L. de Brito Alves
Affiliation:
Department of Physical Education and Sport Sciences, Academic Center of Vitória (CAV), Federal University of Pernambuco, Vitória do Santo Antão, Brazil
M. R. V. Santos
Affiliation:
Department of Physiology, Federal University of Sergipe, São Cristovão, Brazil
L. C. Brito
Affiliation:
Department of Nutrition, Federal University of Sergipe, São Cristovão, Brazil
E. Nascimento
Affiliation:
Department of Nutrition, Federal University of Pernambuco, Recife, Brazil
J. H. Costa-Silva
Affiliation:
Department of Physical Education and Sport Sciences, Academic Center of Vitória (CAV), Federal University of Pernambuco, Vitória do Santo Antão, Brazil
V. J. Santana-Filho
Affiliation:
Department of Physiology, Federal University of Sergipe, São Cristovão, Brazil
*
*Address for correspondence: R. V. dos Santos, Department of Physiology, Federal University of Sergipe, Frei Paulo St. 445, apt 303, Building Pegasus, Aracaju/SE 49052-270, Brazil. (Email robervanvidal@hotmail.com)
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Abstract

The present study investigated the impact of a western diet during gestation and lactation on the anthropometry, serum biochemical, blood pressure and cardiovascular autonomic control on the offspring. Male Wistar rats were divided into two groups according to their mother’s diet received: control group (C: 18% calories of lipids) and westernized group (W: 32% calories of lipids). After weaning both groups received standard diet. On the 60th day of life, blood samples were collected for the analysis of fasting glucose and lipidogram. Cardiovascular parameters were measured on the same period. Autonomic nervous system modulation was evaluated by spectrum analysis of heart rate (HR) and systolic arterial pressure (SAP). The W increased glycemia (123±2 v. 155±2 mg/dl), low-density lipoprotein (15±1 v. 31±2 mg/dl), triglycerides (49±1 v. 85±2 mg/dl), total cholesterol (75±2 v. 86±2 mg/dl), and decreased high-density lipoprotein (50±4 v. 38±3 mg/dl), as well as increased body mass (209±4 v. 229±6 g) than C. Furthermore, the W showed higher SAP (130±4 v. 157±2 mmHg), HR (357±10 v. 428±14 bpm), sympathetic modulation to vessels (2.3±0.56 v. 6±0.84 mmHg2) and LF/HF ratio (0.15±0.01 v. 0.7±0.2) than C. These findings suggest that a western diet during pregnancy and lactation leads to overweight associated with autonomic misbalance and hypertension in adulthood.

Keywords

autonomic controlhypertensionoffspringwesternized diet
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 8 , Issue 2 , April 2017 , pp. 216 - 225
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Copyright
© Cambridge University Press 2016. This is a work of the U.S. Government and is not subject to copyright protection in the United States. 

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