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Adult worm tegumental damage and egg-granulomas in praziquantel-resistant and -susceptible Schistosoma mansoni treated in vivo

Published online by Cambridge University Press:  12 April 2024

Y.-S. Liang ,
G.C. Coles ,
J.-R. Dai ,
Y.-C. Zhu  and
M.J. Doenhoff
Y.-S. Liang
Affiliation:
Jiangsu Institute of Parasitic Diseases, Meiyuan, Wuxi, Jiangsu 214064, People's Republic of China: Department of Clinical Veterinary Science, University of Bristol, Langford House, Langford, Bristol, BS40 5DU, UK
G.C. Coles*
Affiliation:
Department of Clinical Veterinary Science, University of Bristol, Langford House, Langford, Bristol, BS40 5DU, UK
J.-R. Dai
Affiliation:
Jiangsu Institute of Parasitic Diseases, Meiyuan, Wuxi, Jiangsu 214064, People's Republic of China:
Y.-C. Zhu
Affiliation:
Jiangsu Institute of Parasitic Diseases, Meiyuan, Wuxi, Jiangsu 214064, People's Republic of China:
M.J. Doenhoff
Affiliation:
3School of Biological Sciences, University of Wales, Bangor, Gwynedd, LL57 2UW, UK
*
*Fax: +44 (0) 117 928 9505 E-mail: gerald.c.coles@bristol.ac.uk
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Abstract

The effect of treatment with praziquantel (PZQ) on the tegument of adult Schistosoma mansoni worms and on liver egg-granulomas has been examined in mice infected with PZQ-resistant and -susceptible parasite isolates. Two PZQ-resistant S. mansoni isolates, one selected by passage in the laboratory under drug pressure and one from Senegal established from eggs excreted by an uncured patient, were compared with PZQ-susceptible control isolates. Scanning electron microscopic observations on the tegument of Schistosoma adult worms treated in vivo with PZQ showed that more severe damage was inflicted by PZQ on susceptible worms than on drug-resistant worms. Observations on the pathology of Schistosoma egg-granulomas in the liver of infected mice after treatment with PZQ indicated that eggs from susceptible control isolates were more sensitive to PZQ than those from drug-resistant isolates.

Type
Research Article
Information
Journal of Helminthology , Volume 76 , Issue 4 , December 2002 , pp. 327 - 333
Copyright
Copyright © Cambridge University Press 2002

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