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The effect of cadmium on the immune behaviour of guinea pigs with experimental ascariasis

Published online by Cambridge University Press:  05 June 2009

Z. Borošková  and
E. Dvorožňáková
Z. Borošková
Affiliation:
Parasitological Institute SAS, Hlinkova 3, Košice, Slovak Republic
E. Dvorožňáková
Affiliation:
Parasitological Institute SAS, Hlinkova 3, Košice, Slovak Republic
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Abstract

The subchronic effect of cadmium on selected immunological parameters was studied in guinea pigs with experimental ascariasis. Cadmium chloride given orally for 28 days caused a considerable suppression of T- and B- cells in the lymphoid organs of intoxicated animals, of the metabolic activity of their peritoneal macrophages and a moderate decline in the level of complement CH50 and AH50 from day 1 to day 28 of the experiment, in comparison with the initial value. After a subsequent infection of the subchronically intoxicated guinea pigs the values for both the cell populations and the macrophage metabolic activity remained considerably suppressed, compared with infected control animals. The phagocytic and metabolic activity of macrophages as well as the CH50 and AH50 level, however, increased conspicuously for a short time after application of heavy metal and after infection but it did not reach the level of the infected group. The level of specific circulating antibodies was not affected by intoxication. Compared with the controls, the mean intensity of infection with Ascaris larvae migrating in the lungs of intoxicated animals increased by 20%. The results have established the negative effect of cadmium on the immunological parameters of the cellular immunity and humoral immunity studied and the impairment of the organism's response to the antigenic stimulus after an A. suum infection.

Information

Type
Research Papers
Information
Journal of Helminthology , Volume 71 , Issue 2 , June 1997 , pp. 139 - 146
Copyright
Copyright © Cambridge University Press 1997

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References

Anon. (1986) Manual of veterinary parasitological laboratory techniques. 24 pp. Ministry of Agriculture, Fisheries and Food, Her Majesty's Stationary Office.Google Scholar
Bencko, V., Cikrt, M. & Lener, J. (1984) Toxic metals in working and living environment of man. pp. 125–144. Prague, Avicenum.Google Scholar
Borošková, Z., Šoltýs, J. & Benková, M. (1995) Comparison between the occurrence of T- and B-cells in the lymphoid organs of guinea pigs after heavy metal intoxication and experimental ascariosis. Helminthologia 32, 181–185.Google Scholar
Bruin, De A.D. (1980) Biochemical toxicology of environmental agents. pp. 1436–1438. Netherlands, Elsevier/North-Holland Biomedical Press.Google Scholar
Chopra, R.K. (1985) A nonimmunomodulatory effect of chronic cadmium exposure on lymphocyte transformation response in Rhesus monkeys (Macaca mulatta). Experimental Cellular Biology 53, 19–23.Google ScholarPubMed
Cook, J.A., Hoffmann, E.O. & Di Luzio, N.R. (1975) Influence of lead and cadmium on the susceptibility of rats to bacterial challenge. Proceedings of the Society for Experimental Biology and Medicine 150, 741–747.CrossRefGoogle ScholarPubMed
Descotes, J. (1992) Immunotoxicology of cadmium. pp. 385–390in Nordberg, G.E., Herber, R.F.M. & Alessio, L. (Eds) Cadmium in human environment: toxicity and carcinogenicity. Lyon, International Agency for Research of Cancer.Google Scholar
Greenspan, B.J. & Morrow, P.E. (1984) The effects of in vitro and aerosol exposures to cadmium on phagocytosis by rat pulmonary macrophages. Fundamental and Applied Toxicology 4, 48–57.CrossRefGoogle ScholarPubMed
Koller, L.D. (1973) Immunosuppression produced by lead, cadmium and mercury. American Journal of Veterinary Research 34, 1457–1458.Google ScholarPubMed
Koller, L.D., Exon, J.H. & Roan, J.G. (1976) Humoral antibody response in mice after single dose exposure to lead or cadmium. Proceedings of the Society for Experimental Biology and Medicine 151, 339–342.CrossRefGoogle ScholarPubMed
Krupicer, I. (1985) Effect of mercury-dominated heavy metal emission on the course of pasture helminthoses in sheep. Veterinární Medicina (Czech) 40, 11–15.Google Scholar
Lokaj, J. (1986) Tetrazolium reductase activity of the leucocytes. Imunologický Zpravodaj 1, 42–44.Google Scholar
Mančal, J. (1985) Immunoenzyme analysis methods. 83 pp. Prague, ÚSOL.Google Scholar
Staršia, Z. (1986) The determination of the level of complement, pp. 47–105in Procházková, M. & John, C. (Eds) The selected techniques in medical immunology. Prague, Avicenum.Google Scholar
Soulsby, E.J.L. (1987) Immunology, immunopathology and immunoprophylaxis of Ascaris spp. pp. 127–140in Soulsby, E.J.L. (Ed.) Immune responses in parasitic infections. Vol.1. Florida, CRC Press Inc.Google Scholar
Šoltýs, J., Borošková, Z. & Benková, M. (1994) Comparison of the acute and subacute effect of the industrial heavy metal emission on the cellular immunity of guinea pigs with experimental ascariosis. Helminthologia 31, 111–116.Google Scholar
Thomas, P.T., Ratajczak, H.V., Aranyi, C., Gibbons, R. & Fenters, J.D. (1985) Evaluation of host resistance and immune function in cadmium-exposed mice. Toxicology and Applied Pharmacology 80, 446–456.CrossRefGoogle ScholarPubMed
Toman, M. & Pšikal, J. (1985) Test of the phagocytic activity in calves. Veterinární Medicina (Czech) 7, 393–400.Google Scholar
Wagner, W. & Wagnerová, M. (1988) Ecoimmunology. pp. 122–144. Prague, Avicenum.Google Scholar
Winchester, R.J. & Ross, G.D. (1987) Enumerating cell populations, pp.221–223in Rose, N.R., Friedman, H. & Fahey, J.L. (Eds) Manual of clinical laboratory immunology. Washington DC, American Society for Microbiology.Google Scholar