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Effect of diethylcarbamazine on the concentration of Onchocerca volvulus microfilariae in hydrocoele fluid and urine

Published online by Cambridge University Press:  05 June 2009

Oladele O. Kale
Oladele O. Kale
Affiliation:
Department of Preventive and Social Medicine, University College Hospital, Ibadan, Nigeria
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Abstract

The effect of graded doses of diethylcarbamazine on the concentration of microfilariae in the hydrocoele fluid, urine and skin of patients suffering from onchocerciasis was studied. The results showed that a significant number of microfilariae migrated into hydrocoele fluid and urine immediately after the drug was given and thereafter returned to pre-treatment levels rather more quickly in the former than the latter. The increase was found to be roughly directly proportional to the intensity of infection in the skin. By contrast the skin concentration of microfilariae fell sharply after treatment and remained significantly lower than pre-treatment levels for over four weeks. The potential use to which these observations could be put with respect to clinical screening of drugs in onchocerciasis is discussed.

Type
Research Papers
Information
Journal of Helminthology , Volume 53 , Issue 2 , June 1979 , pp. 169 - 174
Copyright
Copyright © Cambridge University Press 1979

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References

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