Sipahi, Aytan Miranda and Baptista, Daniel Machado 2017. Helminths as an alternative therapy for intestinal diseases. World Journal of Gastroenterology, Vol. 23, Issue. 33, p. 6009.
Pastille, Eva Frede, Annika McSorley, Henry J. Gräb, Jessica Adamczyk, Alexandra Kollenda, Sebastian Hansen, Wiebke Epple, Matthias Buer, Jan Maizels, Rick M. Klopfleisch, Robert Westendorf, Astrid M. and Loke, P'ng 2017. Intestinal helminth infection drives carcinogenesis in colitis-associated colon cancer. PLOS Pathogens, Vol. 13, Issue. 9, p. e1006649.
Williams, Andrew R. Dige, Anders Rasmussen, Tue Kruse Hvas, Christian L. Dahlerup, Jens F. Iversen, Lars Stensvold, C. Rune Agnholt, Jørgen and Nejsum, Peter 2017. Immune responses and parasitological observations induced during probiotic treatment with medicinal Trichuris suis ova in a healthy volunteer. Immunology Letters, Vol. 188, p. 32.
Elliott, D. E. and Weinstock, J. V. 2017. Nematodes and human therapeutic trials for inflammatory disease. Parasite Immunology, Vol. 39, Issue. 5, p. e12407.
Atya, Hanaa B. Ali, Sahar A. Hegazy, Mohamed I. and El Sharkawi, Fathia Z. 2017. Urinary Urea, Uric Acid and Hippuric Acid as Potential Biomarkers in Multiple Sclerosis Patients. Indian Journal of Clinical Biochemistry,
Maizels, R.M. 2016. Parasitic helminth infections and the control of human allergic and autoimmune disorders. Clinical Microbiology and Infection, Vol. 22, Issue. 6, p. 481.
Cvetkovic, J. Sofronic-Milosavljevic, Lj. Ilic, N. Gnjatovic, M. Nagano, I. and Gruden-Movsesijan, A. 2016. Immunomodulatory potential of particular Trichinella spiralis muscle larvae excretory–secretory components. International Journal for Parasitology, Vol. 46, Issue. 13-14, p. 833.
Schmitz, Katja Barthelmes, Julia Stolz, Leonie Beyer, Susanne Diehl, Olaf and Tegeder, Irmgard 2015. “Disease modifying nutricals” for multiple sclerosis. Pharmacology & Therapeutics, Vol. 148, p. 85.
Bashi, Tomer Bizzaro, Giorgia Ben-Ami Shor, Dana Blank, Miri and Shoenfeld, Yehuda 2015. The mechanisms behind helminth's immunomodulation in autoimmunity. Autoimmunity Reviews, Vol. 14, Issue. 2, p. 98.
Leonardi, Irina Frey, Isabelle and Rogler, Gerhard 2015. Helminth therapy for organic diseases?. Translational Research, Vol. 166, Issue. 6, p. 586.
Fleming, J. O. and Weinstock, J. V. 2015. Clinical trials of helminth therapy in autoimmune diseases: rationale and findings. Parasite Immunology, Vol. 37, Issue. 6, p. 277.
Vejzagić, Nermina Adelfio, Roberto Keiser, Jennifer Kringel, Helene Thamsborg, Stig Milan and Kapel, Christian M.O. 2015. Bacteria-induced egg hatching differs for Trichuris muris and Trichuris suis. Parasites & Vectors, Vol. 8, Issue. 1,
Voldsgaard, A Bager, P Garde, E Åkeson, P Leffers, AM Madsen, CG Kapel, C Roepstorff, A Thamsborg, SM Melbye, M Siebner, H Søndergaard, HB Sellebjerg, F and Sørensen, P Soelberg 2015. Trichuris suis ova therapy in relapsing multiple sclerosis is safe but without signals of beneficial effect. Multiple Sclerosis Journal, Vol. 21, Issue. 13, p. 1723.
Nascimento, Wheverton C. Silva, Roeckson P. Fernandes, Erica S. Silva, Maria C. Holanda, Gabriela C. Santos, Patrícia A. Albuquerque, Mônica P. Costa, Vlaudia A. Pontes-Filho, Nicodemos T. and Souza, Valdênia O. 2014. Immunomodulation of liver injury by Ascaris suum extract in an experimental model of autoimmune hepatitis. Parasitology Research, Vol. 113, Issue. 9, p. 3309.
Ebner, F. Hepworth, M. R. Rausch, S. Janek, K. Niewienda, A. Kühl, A. Henklein, P. Lucius, R. Hamelmann, E. and Hartmann, S. 2014. Therapeutic potential of larval excretory/secretory proteins of the pig whipwormTrichuris suisin allergic disease. Allergy, Vol. 69, Issue. 11, p. 1489.
Lin, Chen Hsing Kadakia, S. and Frieri, Marianne 2014. New insights into an autoimmune mechanism, pharmacological treatment and relationship between multiple sclerosis and inflammatory bowel disease. Autoimmunity Reviews, Vol. 13, Issue. 2, p. 114.
Correale, Jorge 2014. Helminth/Parasite Treatment of Multiple Sclerosis. Current Treatment Options in Neurology, Vol. 16, Issue. 6,
Initial clinical trials using Trichuris suis eggs (TSO) in autoimmune diseases such as inflammatory bowel disease, revealed a striking suppressive effect on the autoimmune response. Here, we analysed the effect of TSO therapy on the course of multiple sclerosis (MS), as a Th1/Th17-associated autoimmune disease. Different immunological parameters in four patients with secondary progressive MS were surveyed during a 6-month therapy with TSO, focusing on the modulation of T-cell Th1–Th2 balance as well as on the innate immune response. We are able to show a slight downregulation of the Th1-associated cytokine pattern, especially relevant in interleukin (IL)-2 (P < 0.05 after 2 months of therapy), with a temporary increase of Th2-associated cytokines such as IL-4. Furthermore, mild eosinophily and changes in CD4+ and CD8+T cells and natural killer (NK) CD56 bright cell numbers were observed. The findings observed in this group of patients suggest that TSO therapy has a moderate immunomodulatory impact in MS.
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