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Nitazoxanide in the treatment of Ascaris lumbricoides in a rural zone of Colima, Mexico

  • M.L. Galvan-Ramirez (a1), N. Rivera (a1), M.E. Loeza (a1), X. Avila (a1), J. Acero (a1), R. Troyo (a1) and R. Bernal (a2)...

Intestinal parasites in Mexico are an endemic problem. A study was conducted in children, teenagers and adults in a rural community in Colima, Mexico to examine the prevalence and intensity of Ascaris lumbricoides infection and to evaluate the parasitological and clinical efficacy of nitazoxanide (NTZ). Two hundred and eighty children, teenagers and adults participated in this study. Parasitological diagnosis from faeces was confirmed by three consecutive stool samples using the floatation concentration Faust method. Egg counts were performed as described by the Kato–Katz technique before and after treatment. A questionnaire was systematically applied to obtain information about socio-economic status and hygienic habits. One hundred and six participants (38%) were diagnosed as harbouring intestinal parasites, and 86 of them (81%) were infected with A. lumbricoides. All patients with ascariasis infections underwent a complete physical examination before and after NTZ treatment. NTZ resolved 88% of the ascariasis cases, with a 89% clinical efficacy, and there was a 97.5% reduction in the levels of morbidity. The most intense infections for A. lumbricoides were found in housewives, and statistically significant associations were found between ascariasis and the absence of drainage and living in houses with dirt floors.

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Abaza, H., El-Zayali, A., Kabil, S.M. & Rizk, H. (1998) Nitazoxanide in the treatment of patients with intestinal protozoan and helmintic infections: a report on 546 patiens in Egypt. Current Therapeutic Research 59, 116121.
Amadi, B., Mwiya, M., Musuku, J., Watusu, A., Sianongo, S., Ayoub, A. & Kelly, P. (2002) Effect of nitazoxanide on morbidity and mortality in Zambian children with cryptosporidiosis: a randomised controlled trial. Lancet 360, 13751380.
Cooperstock, M., DuPont, H., Corrado, M., Fekety, R. & Morgan, D. (1992) Evaluation of new anti-infective drugs for the treatment of diarrhea caused by Giardia lamblia. Clinical Infectious Disease 15 (Suppl), 244248.
Dávila, C., Vasquez, C., Trujillo, B. & Huerta, M. (2002) Nitazoxanide compared with quinfamide and mebendazole in the treatment of helminthic infections and intestinal protozoa in children. American Journal of Tropical Medicine and Hygiene 66, 251254.
Diaz, E., Mondragon, J., Ramirez, E. & Bernal, R. (2003) Epidemiology and control of intestinal parasites with nitazoxanide in children in Mexico. American Journal of Tropical Medicine and Hygiene 68, 384385.
Doumbo, O., Rossignol, J.F., Pichard, E., Troare, H.A., Dembele, M., Diakite, M., Traore, F. & Diallo, D.A. (1999) Nitazoxanide in the treatment of cryptosporidial diarrhea and other intestinal parasitic infectious associated with acquired immunodeficiency syndrome in tropical Africa. American Journal Tropical Medicine and Hygiene 56, 637639.
Fox, L. & Saravolatz, L. (2005) Nitazoxanide: A new thiazolide antiparasitic agent. Clinical Infectious Disease 40, 11731179.
Geerts, S. & Gryseels, B. (2000) Drug resistance in human helminths: Current situation on lessons from livestock. Clinical Microbiology Reviews 13, 207222.
Geets, S., Coles, G.C. & Gryseels, B. (1997) Anthelmintic resistance in human helminths: learning from the problem with worm control in livestock. Parasitology Today 13, 149151.
Gilles, H. & Hoffman, P. (2002) Treatment of intestinal parasitic infections: a review of nitazoxanide. Trends in Parasitology 18, 9597.
Hall, A., Anwar, K.S. & Tomkins, M.A. (1992) Intensity of reinfection with Ascaris lumbricoides and its implications for parasite control. Lancet 339, 12531257.
INDRE (Instituto Nacional de Diagnóstico y Referencia Epidemiológicas) (1994) Encuestas centinelas para la evaluación de la eficacia de la quimioterapia masiva contra helmintos intestinales de octubre de 1993. México.
NCCLS (National Committee for Clinical Laboratory Standard) (1997) Procedures for the recovery and identification of parasites from intestinal tract. Approved Guideline. Pennsylvania, NCCLS.
Ortiz, J., Ayoub, A., Gargala, G., Chegne, N.L. & Favennec, L. (2001) Randomized clinical study of nitazoxanide compared to metronidazole in the treatment of symptomatic giardiasis in children from Northern Peru. Alimentary Pharmacology and Therapeutics 15, 14091415.
Romero, C.R., Robert, G.L., Muñoz, G.R. & Geyne, C.A. (1997) Nitaxozanide in the treatment of patients with intestinal protozoan and helminthic infections in Mexico. Transactions of the Royal Society of Tropical Medicine and Hygiene 91, 701703.
Rossignol, J. F. & Cavier, R. (1975) New derivative of 2-benzamido-5-nitrothiols. Chemical Abstracts 83, abstract 28216n.
Rossignol, J.F., Abaza, H. & Friedman, H. (1998) Successful treatment of human fascioliasis with nitazoxanide. Transactions of the Royal Society of Tropical Medicine and Hygiene 92, 103104.
Smith, H.M., DeKaminsky, R.G., Niwas, S., Soto, R.J. & Jolly, P.E. (2001) Prevalence and intensity of infections of Ascaris lumbricoides and Trichuris trichiura and associated socio-demographic variables in four rural Honduran communities. Memory Institute Oswaldo Cruz 96, 303314.
Torres, M., Flisser, A., Aguirre, M.T., Velasco, O., Mañon, M.L., Guzman, C., Dominguez, L., Gonzalez, G., Nava, M., del Rio, A., Garcia, L. & Valdespino, J.L. (2000) México. pp. 56–60 in OPS/OMS (Eds) Reunión sobre el control de las helmintiosis intestinales en el contexto de AIEPI. Rio de Janeiro, Brasil.
WHO (World Health Organization) (1987) Prevention and control of intestinal parasitic infections. Report of a WHO Expert Committee. Ginebra Technical Report Series 749: 1–86.
WHO (World Health Organization) (1996) Monitoring large-scale integrated control programmes: the Mexican experience. Report of the WHO informal consultation on the use of chemotherapy for the control of morbidity due to soil-transmitted nematodes in humans. WHO/CTD/SIP/96.2, pp. 32–36. Geneva, WHO.
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Journal of Helminthology
  • ISSN: 0022-149X
  • EISSN: 1475-2697
  • URL: /core/journals/journal-of-helminthology
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