Skip to main content
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 8
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Gan, Richard Wei Chern Gohil, Rohit Belfield, Katherine Davies, Patrick and Daniel, Matija 2014. Acute airway obstruction by Ascaris lumbricoides in a 14-month-old boy. International Journal of Pediatric Otorhinolaryngology, Vol. 78, Issue. 10, p. 1795.

    Conterno, Lucieni O Garcia, Marcos VF Mukai, Natalia S and Conterno, Lucieni O 2013. Cochrane Database of Systematic Reviews.

    Galván-Ramírez, Ma. de la Luz Dueñas Jiménez, Judith Marcela Rocío Rodríguez Pérez, Laura Troyo-Sanroman, Rogelio Ramírez-Herrera, Mario and García-Iglesias, Trinidad 2013. Effect of Nitaxozanide and Pyrimethamine on Astrocytes Infected by Toxoplasma gondii In Vitro. Archives of Medical Research, Vol. 44, Issue. 6, p. 415.

    Marcelín-Jiménez, Gabriel Contreras-Zavala, Leticia Maggi-Castellanos, Martha Ángeles-Moreno, Alionka P and García-González, Alberto 2012. Development of a method by UPLC–MS/MS for the quantification of tizoxanide in human plasma and its pharmacokinetic application. Bioanalysis, Vol. 4, Issue. 8, p. 909.

    Kappagoda, Shanthi Singh, Upinder and Blackburn, Brian G. 2011. Antiparasitic Therapy. Mayo Clinic Proceedings, Vol. 86, Issue. 6, p. 561.

    MAGUIRE, JAMES H. 2010. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases.

    Weese, J. Scott Peregrine, Andrew S. Anderson, Maureen E. C. and Fulford, Martha B. 2010. Companion Animal Zoonoses.

    Khandelwal, Niraj Shaw, Joanna and Jain, Mamta K. 2008. Biliary parasites: Diagnostic and therapeutic strategies. Current Treatment Options in Gastroenterology, Vol. 11, Issue. 2, p. 85.


Nitazoxanide in the treatment of Ascaris lumbricoides in a rural zone of Colima, Mexico

  • M.L. Galvan-Ramirez (a1), N. Rivera (a1), M.E. Loeza (a1), X. Avila (a1), J. Acero (a1), R. Troyo (a1) and R. Bernal (a2)
  • DOI:
  • Published online: 01 September 2007

Intestinal parasites in Mexico are an endemic problem. A study was conducted in children, teenagers and adults in a rural community in Colima, Mexico to examine the prevalence and intensity of Ascaris lumbricoides infection and to evaluate the parasitological and clinical efficacy of nitazoxanide (NTZ). Two hundred and eighty children, teenagers and adults participated in this study. Parasitological diagnosis from faeces was confirmed by three consecutive stool samples using the floatation concentration Faust method. Egg counts were performed as described by the Kato–Katz technique before and after treatment. A questionnaire was systematically applied to obtain information about socio-economic status and hygienic habits. One hundred and six participants (38%) were diagnosed as harbouring intestinal parasites, and 86 of them (81%) were infected with A. lumbricoides. All patients with ascariasis infections underwent a complete physical examination before and after NTZ treatment. NTZ resolved 88% of the ascariasis cases, with a 89% clinical efficacy, and there was a 97.5% reduction in the levels of morbidity. The most intense infections for A. lumbricoides were found in housewives, and statistically significant associations were found between ascariasis and the absence of drainage and living in houses with dirt floors.

Corresponding author
*Fax +52 5761 80 01 E-mail:
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

H. Abaza , A. El-Zayali , S.M. Kabil & H. Rizk (1998) Nitazoxanide in the treatment of patients with intestinal protozoan and helmintic infections: a report on 546 patiens in Egypt. Current Therapeutic Research 59, 116121.

B. Amadi , M. Mwiya , J. Musuku , A. Watusu , S. Sianongo , A. Ayoub & P. Kelly (2002) Effect of nitazoxanide on morbidity and mortality in Zambian children with cryptosporidiosis: a randomised controlled trial. Lancet 360, 13751380.

L. Fox & L. Saravolatz (2005) Nitazoxanide: A new thiazolide antiparasitic agent. Clinical Infectious Disease 40, 11731179.

S. Geerts & B. Gryseels (2000) Drug resistance in human helminths: Current situation on lessons from livestock. Clinical Microbiology Reviews 13, 207222.

S. Geets , G.C. Coles & B. Gryseels (1997) Anthelmintic resistance in human helminths: learning from the problem with worm control in livestock. Parasitology Today 13, 149151.

H. Gilles & P. Hoffman (2002) Treatment of intestinal parasitic infections: a review of nitazoxanide. Trends in Parasitology 18, 9597.

A. Hall , K.S. Anwar & M.A. Tomkins (1992) Intensity of reinfection with Ascaris lumbricoides and its implications for parasite control. Lancet 339, 12531257.

J. Ortiz , A. Ayoub , G. Gargala , N.L. Chegne & L. Favennec (2001) Randomized clinical study of nitazoxanide compared to metronidazole in the treatment of symptomatic giardiasis in children from Northern Peru. Alimentary Pharmacology and Therapeutics 15, 14091415.

J.F. Rossignol , H. Abaza & H. Friedman (1998) Successful treatment of human fascioliasis with nitazoxanide. Transactions of the Royal Society of Tropical Medicine and Hygiene 92, 103104.

H.M. Smith , R.G. DeKaminsky , S. Niwas , R.J. Soto & P.E. Jolly (2001) Prevalence and intensity of infections of Ascaris lumbricoides and Trichuris trichiura and associated socio-demographic variables in four rural Honduran communities. Memory Institute Oswaldo Cruz 96, 303314.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Journal of Helminthology
  • ISSN: 0022-149X
  • EISSN: 1475-2697
  • URL: /core/journals/journal-of-helminthology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *