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  • Cited by 6
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    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Chappell, L. H. 1988. The interactions between drugs and the parasite surface. Parasitology, Vol. 96, Issue. S1, p. S167.

    Popiel, I. 1986. The reproductive biology of schistosomes. Parasitology Today, Vol. 2, Issue. 1, p. 10.

    Watts, Stuart D.M. 1986. Schistosoma mansoni: Nitrothiazolines and the male tegument. Experimental Parasitology, Vol. 62, Issue. 2, p. 157.

    Popiel, Irene and Erasmus, David A. 1984. Schistosoma mansoni: Ultrastructure of adults from mice treated with oxamniquine. Experimental Parasitology, Vol. 58, Issue. 3, p. 254.

    Popiel, Irene Cioli, Donato and Erasmus, David A. 1984. The morphology and reproductive status of female Schistosoma mansoni following separation from male worms. International Journal for Parasitology, Vol. 14, Issue. 2, p. 183.

    Shaw, Michael K. and Erasmus, David A. 1984. Schistosoma mansoni: Electron probe X-ray microanalysis of the elemental composition of the tegument and subtegumental tissues of adult worms. Experimental Parasitology, Vol. 58, Issue. 2, p. 163.


Schistosoma mansoni: the survival and reproductive status of mature infections in mice treated with oxamniquine

  • Irene Popiel (a1) and David A. Erasmus (a1)
  • DOI:
  • Published online: 18 November 2009

A single oral dose of 50 mg/kg of oxamniquine administered to mice with mature infections of Schistosoma mansoni gave rise to a hepatic shift and almost total elimination of the male worms. Regression of the reproductive system and a conspicuous reduction in size took place in the residual females which eventually resembled sexually immature adults. A second dose of oxamniquine had no apparent effect on these females within a period of 28 days following this treatment and it is suggested that this change in reproductive status is the result of discontinued male stimulation.

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R. Foster & B. L. Cheetham (1973) Studies with the schistosomicide oxamniquine (UK-4271) 1. Activity in rodents and in vitro. Transactions of the Royal Society of Tropical Medicine and Hygiene, 67, 674684.

R. M. Michaels (1969) Mating of Schistosoma mansoniin vitro. Experimental Parasitology, 25, 5871.

J. R. Shaw , I. Marshall & D. A. Erasmus (1977) Schistosoma mansoni: In vitro stimulation of vitelline cell development by extracts of male worms. Experimental Parasitology, 42, 1420.

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Journal of Helminthology
  • ISSN: 0022-149X
  • EISSN: 1475-2697
  • URL: /core/journals/journal-of-helminthology
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