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Specific cross-immunity between Hymenolepis nana and H. diminuta: immunization with heterologous and homologous light infections

Published online by Cambridge University Press:  05 June 2009

F. Gabriele ,
D. Wakelin  and
C. Palmas
F. Gabriele
Affiliation:
Istituto di Parassitologia, Via della Pineta, 77 09125 Cagliari, Italy
D. Wakelin
Affiliation:
MRC Experimental Parasitology Group, Department of Zoology, University of Nottingham, Nottingham NG7 2RD, U.K.
C. Palmas
Affiliation:
Istituto di Parassitologia, Via della Pineta, 77 09125 Cagliari, Italy
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Abstract

The consequences of previous and concurrent infection with two related species of cestodes, Hymenolepis nana and H. diminuta, were studied in CD1 mice. A H. diminuta infection strongly affected the establishment and the survival of a secondary H. nana egg or cyst infection administered 30 days later. An infection of 20 H. nana eggs strongly protected against a 5-cyst H. diminuta challenge, whereas an infection of 10 H. nana cysts was ineffective; 20 H. nana eggs also protected against a challenge with 5 cysts of H. diminuta administered 5 days later. No effects were observed in either parasite during a concurrent infection established by administration of cysts. An H. nana egg-infection was unable to affect the establishment of a secondary H. nana cyst-infection given 1 month later; however a significant decrease in growth was found. Similar results were found when a primary H. nana egg-infection was followed 5 days later by the homologous cyst-infection. But an infection with 5 H. nana cysts was unable to protect against a homologous challenge of 5 cysts or 20 eggs. The reciprocal cross immunity between the heterologous parasites and the failure of protection of homologous challenges are discussed in relation to light infections.

Keywords

Hymenolepis nanaHymenolepis diminutaimmune responsescross immunityconcurrent infectionimmunogenicitytissue phaselumenal phase
Type
Research Papers
Information
Journal of Helminthology , Volume 62 , Issue 2 , June 1988 , pp. 115 - 123
Copyright
Copyright © Cambridge University Press 1988

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