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Spirometra mansonoides: effects of plerocercoid infection on glycogen deposition in rats

Published online by Cambridge University Press:  18 November 2009

C. K. Phares  and
Nguyen Duy Ai
C. K. Phares
Affiliation:
Department of Biochemistry, University of Nebraska Medical Center, Omaha, Nebraska 68105, USA
Nguyen Duy Ai
Affiliation:
Department of Biochemistry, University of Nebraska Medical Center, Omaha, Nebraska 68105, USA
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Abstract

The effects of infection with plerocercoids of Spirometra mansonoides on tissue glycogen deposition of rats was determined. Hypophysectomized rats infected for two days had higher liver glycogen concentrations than controls and this effect was greatest after one week. Elevated liver glycogen associated with plerocercoid infection was observed in fed animals both at the beginning and at the end of the light period as well as after an overnight fast. Glycogen phosphorylase (1,4αD glucan: orthophosphate α glucosyltransferase EC 2.4.1.1.) was inhibited but glucose-6-phosphatase (EC 3.1.3.9) was unaffected in the livers of infected hypophysectomized rats. While this effect is similar to actions of both growth hormone and insulin, plerocercoid infection had no influence on glycogen of cardiac or skeletal muscle at any time. Plerocercoid infection had no effect on the glycogen concentration of any tissue of intact rats.

Type
Research Papers
Information
Journal of Helminthology , Volume 56 , Issue 4 , December 1982 , pp. 315 - 322
Copyright
Copyright © Cambridge University Press 1982

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