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Studies of potential filaricides: Part 14—Activity of l-iso-butoxycarbonyl-4-methyIpiperazine against experimental filariasis*

  • R. Rastogi (a1), S. Sharma (a1), N. Anand (a1), A. Dutta, N. Fatma, R. K. Chatterjee and A. B. Sen...
Abstract

The synthesis and filaricidal activity of l-iso-butoxycarbonyl-4-mcthylpipcrazinc against Litomosoides carinii in Sigmodon hispidus and Dipctaloncma viteae in Mastomys natalcnsis is reported. At an intrapcritoncal or oral dose of 3 mg/kg given for 6 days, the compound removed 91% of the circulating microfilariac but had no effect on adult L carinii. However, it killed all microfilariae and adults of D. viteae at a subcutaneous dose of 50 mg/kg given for 6 days. The compound also possessed ehemoprophylaetic activity against the larvae of L. carinii and D. viteae at a dose of 30 and 50 mg/kg respectively.

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Misra, S., Chatterjee, R.K. & Sen, A.B. (1981) Antifilarial action of furazolidone. Indian Journal Medical Research, 73, 725728.
Rastogi, R., Sharma, S., Anand, N., Chowdhury, T.K.R., Chowdhury, T.K., Tyagi, K., Murthy, P.K., Chatterjee, R.K. & Sen, A.B. (1983) A process for the synthesis of 1,4-disubstitutcd piperazines. Indian Patent Application 320/Del/83, 05 16, 1983.
Singh, H., Sharma, S., Iyer, R.N. & Anand, N. (1976a) Studies in potential filaricides: Part VIII—Synthesis of 1-cthyl-3-(2-dialkylaminoethyl) and 1,3-dicthyl-4-dialkylamino mcthylhcxahydropyrimidin- 2-oncs. Indian Journal of Chemistry, 14B, 528531.
Singh, H., Sharma, S., Iyer, R.N. & Anand, N. (1976b) Studies in potential filaricides: Part IX—Synthesis of 1-cthyl-6-oxo-1,4-diazabicyclo[4,3,1]nonan-5-onc, 1,6-dialky1-1,4,6-triazabicyclo[4,3,1]nonan-5-onc and related thio analogs. Indian Journal of Chemistry, 14B, 532535.
Sharma, S., Iyer, R.N., Anand, N., Chatterjee, R.K., Chandra, S., Dutta, A. & Sen, A.B. (1975a) A process for the synthesis of antifilarial-1-substituted-4-carbamoylpiperazines. Indian Patent No. 141941; Chemical Abstract (1980) 92, 164002c.
Sharma, S., Iyer, R.N. & Anand, N. (1975b) Studies in potential filaricides: Part VII—Synthesis of 4,8-dialkyl-1,4,8-triazabicyclo[4,4,0]dccan-2-one, 3,7-diallcyl-1,3,7-triazabicyclo[4,3,0]nonan-2-one and related oxygen analogs. Indian Journal of Chemistry, 13B, 468472.
Sharma, S., Bindra, R., Iyer, R.N. & Anand, N. (1975c) Studies in potential filaricides. Part VI—Synthesis of 3,8-disubstituted-1,3,8-triazabicyclo[4,4,0]decon-2-ones and thioncs. Journal of Medicinal Chemistry, 18, 913917.
Wadia, P.S., Asthana, T.C., Anand, N. & Dhar, M.L. (1958a) Studies in Potential Filaricides: Part-I—Synthesis of N,N-disubstitutcd polymethylene Diamines as Hetrazan Analogs. Journal of Scientific and Industrial Research, 17B, 1124.
Wadia, P.S., Anand, N. & Dhar, M.L. (1958b) Studies in potential filaricides: Part II—Synthesis of substituted imidazolidines and 2-imidazolidinethiones. Journal of Scientific and Industrial Research, 17B, 2430.
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  • ISSN: 0022-149X
  • EISSN: 1475-2697
  • URL: /core/journals/journal-of-helminthology
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