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Studies with Brugia pahangi 7. Changes in lymphatics of injected cats

  • Rosemary Rogers and D. A. Denham (a1)

Abstract

Histological and gross changes in the lymphatics of cats singly or repeatedly infected with Brugia pahangi were studied chronologically over a period of 5 years. Lymphatic dilatation occurred within 2 weeks of injection and an initial acute inflammatory reaction in the lymphatic wall and lumen was followed by chronic inflammation within 4 months. In some long-term repeatedly infected cats, the lymphatics became non-functional fibrous cords and conditions of oedema and early elephantiasis, similar to those seen in early human filariasis, were produced. The main points of contention in the study of filariasis which were cluciaated in this system were: (1) that living worms cause lymphatic damage, not exacerbated by their death; (2) that lymphatic damage is not progressive after a certain peak of reaction is reached, except in repeatedly challenged animals; (3) that microfilariae do not appear to cause lymphatic damage.

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Bloom, W. and Fawcett, D. W. (1968) A textbook of Histology. 9th ed., W. B. Saunders&Co.: Philadelphia, London and Toronto.
Boggon, R. P. and Plafrey, A. J. (1969) Fine structure of human lymphatic trunks. Journal of Anatomy, 105, 192194.
Burn, J. I. (1969) Obstructive lymphopathy. British Journal of Hospital Medicine, 2, 755763.
Castellani, A. (1962) Elephantiasis nostra and elephantiasis tropica; a comparative study. Dermatologlca tropica, 1, 1722.
Cohen, L. B., Nelson, G., Wood, A. M., Manson-Bahr, P. E. C. and Bowen, R. (1961) Lymphangiography in filarial lymphoedema and elephantiasis. American Journal of Tropical Medicine and Hygiene., 10, 843848.
Denham, D. A., Ponnudurai, T., Nelson, G. S., Rogers, Rosemary, and Guy, , Frances. (1972b) Studies with Brugia pahangi 11. The effect of repeated infection on parasite levels in cats. International Journal of Parasitology, 2, 401407.
Ewert, A., Balderach, R. and Elbihari, S. (1972) Lymphographic changes in regional lymphatics of cats infected with Brugia malayi. American Journal of Tropical Medicine and Hygiene., 21, 407414.
Frayley, E. E. and Weiss, L. (1961) An electron microscope study of the lymphatic vessels in the penile skin in the rat. American Journal of Anatomy, 109, 85101.
Galliard, H. (1968) Clinical, pathological and therapeutic aspects of bancroftian and Malayan filariasis. International Congress of Tropical Medicine and Malariology (8th); Teheran. Abstracts and Reviews, 9596.
Gooneratne, B. W. M.Nelson, G. S., Denham, D. A., Furze, H. and Monson, E. (1971) Lymphographic changes in cats with filariasis. Transactions of the Royal Society of Tropical Medicine and Hygiene, 65, 195198.
Hartz, P. H. (1944) Contribution to the histopathology of filariasis. American Journal of Clinical Pathology, 14, 3443.
Lane, C. (1948) Bancroftian filariasis—Biological mechanisms that underly its periodicity and other of its clinical manifestations. Transactions of the Royal Society of Tropical Medicine and Hygiene, 41, 717784.
Leak, L. V. (1970) Electron microscopic observations on lymphatic capillaries and the structural components of the connective tissue—lymph interface. Microvascular Research, 2, 361391.
Nelson, G. S. (1966) The pathology of filarial infections. Helminthological Abstracts, 35, (4) 311336.
O'connor, F. W. and Hulse, C. R. (1932) Some pathological changes associated with Wuchereria (Filaria) bancrofti infection. Transactions of the Royal Society of Tropical Medicine and Hygiene, 25, 445454.
Pfleger, L. (1964) Histology and histopathology of cutaneous lymph vessels of the lower extremities. I. Morphology of cutaneous lymph vessels. II. Pathology of cutaneous lymph vessels. Archiv für Klinishe und Experimented Dermatologie, 221, 122, 23–58.
Reddy, D. B. and Ray, J. C. (1963) Observations on tissue reactions in filariasis with particular reference to histopathological changes in the lymph glands. Journal of the Indian Medical Association, 41, 5361.
Rogers, Rosemary, Denham, D. A., Nelson, G. S., Guy, Frances, and Ponnudurai, T. (1974) Studies with Brugia pahangi 3. Histological changes in the affected lymph nodes of infected cats. Annals of Tropical Medicine and Parasitology, in Press.
Schacher, J. F. and Sahyoun, P. F. (1967) A chronological study of the histopathology of filarial disease in cats and dogs caused by Brugia pahangi (Buckley and Edeson, 1956). Transactions of the Royal Society of Tropical Medicine and Hygiene, 61, 234243.
Schacher, J. F., Sulahain, Annie, and Edeson, J. F. B. (1969) Experimental lymphoedema in dogs infected with Brugia spp. Transactions of the Royal Society of Tropical Medicine and Hygiene, 63, 682683.
Schacher, J. F. and Sulahain, A. (1972) Lymphatic drainage patterns and experimental filariasis in dogs. Annals of Tropical Medicine and Parasitology, 66, 209217.
Schacher, J. F., Edeson, J. F. B., Sulahain, A. and Rizk, G. (1973) An 18-month longitudinal Iymphographic study of filarial disease in dogs infected with Brugia pahangi (Buckley and Edeson,1956). Annals of Tropical Medicine and Parasitology, 67, 8194.
Wartman, W. B. (1944) Lesions of the lymphatic system in early filariasis. American Journal of Tropical Medicine, 24, 299313.
Wartman, W. B. (1947) Filariasis in American Armed Forces in World War II. Medicine, 26, 333394
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Journal of Helminthology
  • ISSN: 0022-149X
  • EISSN: 1475-2697
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