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Variation in the larval recovery of Toxocara canis from the murine brain: implications for behavioural studies

Published online by Cambridge University Press:  05 June 2009

H. Skerrett  and
C.V. Holland
H. Skerrett
Affiliation:
Department of Zoology, Trinity College, Dublin 2, Ireland
C.V. Holland
Affiliation:
Department of Zoology, Trinity College, Dublin 2, Ireland
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Abstract

The migratory pathway of Toxocara canis larvae was determined by infecting mice with a low, medium or high dose of embryonated T. canis eggs and determining numbers of larvae present in the brain, liver, lungs, kidneys and muscle on days 5, 14 and 26 post infection. Variation was seen in the numbers of larvae recorded in the organs of mice which had received the same number of eggs and were at the same stage of infection. This variation was particularly marked in the brain indicating that, for the purposes of behavioural studies, the actual numbers of larvae found in the brain rather than the number assumed from the dose would have to be taken into account when analysing the behaviour of infected mice.

Type
Research Papers
Information
Journal of Helminthology , Volume 71 , Issue 3 , September 1997 , pp. 253 - 256
Copyright
Copyright © Cambridge University Press 1997

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References

Abo-Shehada, M.N. & Herbert, I.V. (1984) The migration of larval Toxocara canis in mice II. Post-intestinal migration in primary infections. Veterinary Parasitology 17, 75–83.CrossRefGoogle ScholarPubMed
Beaver, P.C. (1969) The nature of visceral larva migrans. Journal of Parasitology 55, 3–12.Google Scholar
Carter, K.C. (1992) The use of 35S-labelled Toxocara canis to determine larval numbers in tissues. Journal of Helminthology 66, 279–287.CrossRefGoogle ScholarPubMed
El-Shazly, A.M., Handousa, A.E., Youssef, M.E. & Abo-Shady, A.F. (1991) The effect of the initial inoculum dose and post-infection period on larval dispersal in experimental murine toxocariasis. Journal of the Egyptian Society of Parasitology 21, 785–789.Google ScholarPubMed
Gillespie, S.H. (1993) Human toxocariasis. Communicable Disease Report 3, Review no. 10.Google ScholarPubMed
Glickman, L.T. & Schantz, P.M. (1981) Epidemiology and pathogenesis of zoonotic toxocariasis. Epidemiological Reviews 3, 230–250.CrossRefGoogle ScholarPubMed
Hay, J. & Aitken, P.P. (1984) Experimental toxocariasis in mice and its effect on their behaviour. Annals of Tropical Medicine and Parasitology 78, 145–155.CrossRefGoogle ScholarPubMed
Kayes, S.G., Omholt, P.E. & Grieve, R.B. (1985) Immune responses of CBA/J mice to graded infections with Toxocara canis. Infection and Immunity 48, 697–703.CrossRefGoogle ScholarPubMed
Pritchard, M. & Kruse, G.O.W. (1982) The collection and preservation of animal parasites. p. 13. University of Nebraska Press.Google Scholar
Smith, H.V. (1991) Immune evasion and immunopathology in Toxocara canis infection. pp. 117–139in Kennedy, M.W. (Ed.) Parasitic nematodes – antigens, membranes and genes. London, Taylor & Francis.Google Scholar
Sprent, J.F.A. (1952) On the migratory behaviour of the larvae of various Ascaris species in white mice. II. Longevity of encapsulated larvae and their resistance to freezing and putrefication. Journal of Infectious Diseases 90, 165–176.Google Scholar