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Sensorineural hearing loss following induction chemotherapy plus concurrent chemoradiotherapy for advanced nasopharyngeal carcinoma

Published online by Cambridge University Press:  26 June 2015

V Atchariyasathian*
Affiliation:
Department of Otolaryngology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand
K Pruegsanusak
Affiliation:
Department of Otolaryngology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand
S Wongsriwattanakul
Affiliation:
Department of Otolaryngology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand
*
Address for correspondence: Dr Viraporn Atchariyasathian, Department of Otolaryngology, Prince of Songkla University, 15 Karnjanavanit Road, Songkhla, Thailand90110 Fax: +66 74 429 620 E-mail: aviraporn@gmail.com

Abstract

Objective:

To compare the incidence of sensorineural hearing loss between those treated with docetaxel, cisplatin and 5-fluorouracil induction chemotherapy followed by carboplatin concurrent chemoradiotherapy and those treated with conventional concurrent chemoradiotherapy for advanced nasopharyngeal carcinoma.

Methods:

Serial pure tone audiometry was conducted in 36 nasopharyngeal carcinoma patients who were randomised into 2 groups. The first group received docetaxel, cisplatin and 5-fluorouracil induction chemotherapy followed by carboplatin concurrent chemoradiotherapy. The second group received conventional concurrent chemoradiotherapy.

Results:

The incidence of sensorineural hearing loss at speech frequency in the first group was 10 per cent and in the second group was 50 per cent (p = 0.0027). Bone conduction thresholds were significantly increased after completion of the treatment at 2–4 kHz in the first group and at all frequencies in the second group.

Conclusion:

The docetaxel, cisplatin and 5-fluorouracil induction chemotherapy regimen followed by concurrent chemoradiotherapy was associated with a lower incidence of sensorineural hearing loss than conventional concurrent chemoradiotherapy. This regimen may be the preferred choice of treatment for hearing preservation.

Type
Main Articles
Copyright
Copyright © JLO (1984) Limited 2015 

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