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Adenosquamous carcinoma of maxillary sinus: case showing complete response to S-1

Published online by Cambridge University Press:  20 January 2009

S Suzuki ,
K Hanata ,
H Nanjo  and
K Ishikawa
S Suzuki*
Affiliation:
Department of Otolaryngology and Head and Neck Surgery, Akita University School of Medicine, Akita, Japan
K Hanata
Affiliation:
Department of Otolaryngology and Head and Neck Surgery, Akita University School of Medicine, Akita, Japan
H Nanjo
Affiliation:
Department of Pathology, Akita University School of Medicine, Akita, Japan
K Ishikawa
Affiliation:
Department of Otolaryngology and Head and Neck Surgery, Akita University School of Medicine, Akita, Japan
*
Address for correspondence: Dr Shinsuke Suzuki, Department of Otolaryngology and Head and Neck Surgery, Akita University School of Medicine, Akita, Akita 010-0851, Japan. Fax: +81 (018) 836 2622 E-mail: shinsukesx@hotmail.com
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Abstract

Background:

Adenosquamous carcinoma is a very rare tumour which is characterised pathologically by the simultaneous presence of distinct areas of adenocarcinoma and squamous cell carcinoma. Generally, adenosquamous carcinoma has an aggressive clinical course and is associated with a poor prognosis. Most cases have been treated by surgery alone or combined with radiotherapy. Chemotherapy is rarely used in treating adenosquamous carcinoma, and it has been difficult to establish treatment guidelines due to the paucity of cases.

Case:

We report a case of adenosquamous carcinoma which arose in the maxillary sinus of a 77-year-old man. Despite surgical treatment and chemoradiotherapy to the primary site, he developed bilateral neck metastases after the surgery. The patient was treated with S-1, a novel oral fluoropyrimidine anticancer agent, with a complete (albeit finite) response.

Conclusion:

This report presents the aggressive character of adenosquamous carcinoma and the possible role of S-1 in the treatment of this uncommon neoplasm.

Keywords

Head and Neck NeoplasmsMaxillary NeoplasmsAdenosquamous CarcinomaDrug Therapy
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 123 , Issue 11 , November 2009 , pp. 1271 - 1275
Copyright
Copyright © JLO (1984) Limited 2009

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References

1Pindborg, JJRP, Smith, CJ, Van der Wall, I. Histological Typing of Cancer and Precancer of the Oral Mucosa. New York, Heidelberg, Berlin: Springer, 1997CrossRefGoogle Scholar
2Keelawat, S, Liu, CZ, Roehm, PC, Barnes, L. Adenosquamous carcinoma of the upper aerodigestive tract: a clinicopathologic study of 12 cases and review of the literature. Am J Otolaryngol 2002;23:160–8CrossRefGoogle ScholarPubMed
3Napier, SS, Gormely, JS, Newlands, C, Ramsay-Baggs, P. Adenosquamous carcinoma. A rare neoplasm with an aggressive course. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995;79:607–11CrossRefGoogle ScholarPubMed
4Sheahan, P, Fitzgibbon, J, Lee, G, O'Leary, G. Adenosquamous carcinoma of the tongue in a 22-year-old female: report of a case with immunohistochemistry. Eur Arch Otorhinolaryngol 2003;260:509–12CrossRefGoogle Scholar
5Schoffski, P. The modulated oral fluoropyrimidine prodrug S-1, and its use in gastrointestinal cancer and other solid tumors. Anticancer Drugs 2004;15:85–106CrossRefGoogle ScholarPubMed
6Gerughty, RM, Hennigar, GR, Brown, FM. Adenosquamous carcinoma of the nasal, oral and laryngeal cavities. A clinicopathologic survey of ten cases. Cancer 1968;22:1140–553.0.CO;2-1>CrossRefGoogle ScholarPubMed
7Alos, L, Castillo, M, Nadal, A, Caballero, M, Mallofre, C, Palacin, A et al. Adenosquamous carcinoma of the head and neck: criteria for diagnosis in a study of 12 cases. Histopathology 2004;44:570–9CrossRefGoogle Scholar
8Som, PM, Silvers, AR, Catalano, PJ, Brandwein, M, Khorsandi, AS. Adenosquamous carcinoma of the facial bones, skull base, and calvaria: CT and MR manifestations. AJNR Am J Neuroradiol 1997;18:173–5Google ScholarPubMed
9Yoshimura, Y, Mishima, K, Obara, S, Yoshimura, H, Maruyama, R. Clinical characteristics of oral adenosquamous carcinoma: report of a case and an analysis of the reported Japanese cases. Oral Oncol 2003;39:309–15CrossRefGoogle Scholar
10Sheahan, P, Toner, M, Timon, CV. Clinicopathological features of head and neck adenosquamous carcinoma. ORL J Otorhinolaryngol Relat Spec 2005;67:10–15Google Scholar
11Izumi, K, Nakajima, T, Maeda, T, Cheng, J, Saku, T. Adenosquamous carcinoma of the tongue: report of a case with histochemical, immunohistochemical, and ultrastructural study and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;85:178–84Google Scholar
12Evans, HL. Mucoepidermoid carcinoma of salivary glands: a study of 69 cases with special attention to histologic grading. Am J Clin Pathol 1984;81:696–701Google Scholar
13Abdelsayed, RA, Sangueza, OP, Newhouse, RF, Singh, BS. Adenosquamous carcinoma: a case report with immunohistochemical evaluation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;85:173–7CrossRefGoogle ScholarPubMed
14Ellis, G, Auclair, P. Tumors of the salivary glands. Atlas of Tumor Pathlogy. Bethesda, Maryland: Armed Forces Institute of Pathology, Washington, 1996Google Scholar
15Neville, B, Damm, D, Allen, C, Bouquot, J. Oral & Maxillofacial Pathology. Philadelphia, London, New York, St Louis, Sydney, Toronto: WB Saunders, 2002Google Scholar