Skip to main content
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 6
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Moore, Jaime Greenberg, Caprice and Thibeault, Susan L. 2016. Predictors of Six-month Change in the Voice Handicap Index in a Treatment-seeking Population. Journal of Voice,

    Powell, J. Carding, P. Birdi, R. and Wilson, J.A. 2014. Injection laryngoplasty in the outpatient clinic under local anaesthetic: a case series of sixty-eight patients. Clinical Otolaryngology, Vol. 39, Issue. 4, p. 224.

    Bergamini, G. Alicandri-Ciufelli, M. Molteni, G. Villari, D. Luppi, M.P. Genovese, E. and Presutti, L. 2010. Therapy of Unilateral Vocal Fold Paralysis With Polydimethylsiloxane Injection Laryngoplasty: Our Experience. Journal of Voice, Vol. 24, Issue. 1, p. 119.

    Hagemann, Matthias and Seifert, Eberhard 2008. The Use of Polydimethylsiloxane for Injection Laryngoplasty. World Journal of Surgery, Vol. 32, Issue. 9, p. 1940.

    Randhawa, P S Ramsay, A D and Rubin, J S 2008. Foreign body reaction to polymethylsiloxane gel (Bioplastique™) after vocal fold augmentation. The Journal of Laryngology & Otology, Vol. 122, Issue. 07,

    Zeitler, Daniel M and Amin, Milan R 2007. The thyrohyoid approach to in-office injection augmentation of the vocal fold. Current Opinion in Otolaryngology & Head and Neck Surgery, Vol. 15, Issue. 6, p. 412.


Bioplastique™ injection laryngoplasty: voice performance outcome

  • D W Hamilton (a1), R Sachidananda (a1), P N Carding (a2) and J A Wilson (a1)
  • DOI:
  • Published online: 12 December 2006

Aim: To compare voice performance following Bioplastique™ injection with that following Isshiki thyroplasty.

Measures: A 12 item, self-reported voice performance questionnaire was completed and observer-rated perceptual voice analysis scores were also measured, before and after Bioplastique injection, for 14 patients. Results were compared with our previously reported outcomes for 28 thyroplasty patients.

Results: Only 14 of 30 patients had complete datasets. For these patients, the mean pre-operative voice performance questionnaire score improved significantly, from 40.3 to 18.9 (p=0.002, Wilcoxon test). All perceptual analysis parameters showed significant improvement. These results compare favourably with the thyroplasty cohort (mean voice performance questionnaire score: pre-operative 35; post-operative 18; p<0.001). One Bioplastique patient developed contralateral paresis, requiring partial removal of the material 18 months later. Two thyroplasty patients experienced complications and three required revision.

Conclusions: Both Bioplastique injection and Isshiki thyroplasty resulted in a significant improvement in both subjective and perceptual voice performance. Our data suggest that the effect size of the two interventions is approximately similar (in nonrandomised cohorts of surviving patients). As in many similar studies, the incomplete follow-up data reflect severe comorbidity. Bioplastique injection is a quicker procedure associated with fewer complications, and thus appears superior to framework surgery in patients with limited life expectancy.

Corresponding author
Address for correspondence: Mr David Hamilton, 59 Lavender Gardens, Jesmond, Newcastle Upon Tyne NE2 3DD, UK. E-mail:
Hide All
Presented in part at the International Federation of Otorhinolaryngologists, XVIII World Congress, 25th to 30th June 2005 in Rome, Italy, and at the North of England Otolaryngology Society Spring Meeting, 12th March 2005 in Middlesbrough, England, UK.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *