Skip to main content
×
Home
    • Aa
    • Aa

Causative factors of taste disorders in the elderly, and therapeutic effects of zinc

  • M Ikeda (a1), A Ikui (a1), A Komiyama (a1), D Kobayashi (a1) and M Tanaka (a1)...
Abstract
AbstractObjectives:

To determine the characteristics of causative factors of taste disorders amongst the elderly, and to examine the therapeutic effect of a zinc agent, taking into account age-related factors.

Subjects:

A total of 408 patients with taste disorders were divided into three groups by age: 49 years or younger, 50 to 64 years old, and 65 years or older.

Results:

The incidence of taste disorders caused by drug administration and systemic disease were significantly higher in the elderly group. A serum zinc concentration of 69 µg/dl or lower was found in 33 per cent of the elderly group, significantly more (p < 0.001) than the 19 per cent of the 49 years or younger group with such a concentration. Zinc administration was therapeutically effective in 70 per cent of the whole population studied, and in 74 per cent of the elderly population.

Conclusions:

In the elderly, the incidence of taste disorders caused by drug administration or systemic disease was significantly greater compared with other age groups. The curative effects of zinc administration were not observed to be influenced by age.

Copyright
Corresponding author
Address for correspondence: Dr Minoru Ikeda, Department of Otolaryngology – Head & Neck Surgery, Nihon University School of Medicine, 30-1 Oyaguchi-kamimachi, Itabashi-ku, Tokyo 173-8610, Japan. Fax: +81 3 3972 1321 E-mail: mikeda@med.nihon-u.ac.jp
References
Hide All
1 Deems DA, Doty RL, Settle RG, Moore-Gillon V, Shaman P, Mester AF et al. Smell and taste disorders, a study of 750 patients from the University of Pennsylvania Smell and Taste Center. Arch Otolaryngol Head Neck Surg 1991;117:519–28
2 Hamada N, Endo S, Tomita H. Characteristics of 2278 patients visiting the Nihon University Hospital Taste Clinic over a 10-year period with special reference to age and sex distribution. Acta Otolaryngol Suppl 2002;546:715
3 Grzegorczyk PK, Jones SW, Mistretta CM. Age-related differences in salt taste acuity. J Gerontol 1979;34:834–40
4 Schiffman SS. Taste and smell losses in normal aging and disease. JAMA 1997;278:1357–62
5 Hoffman H, Ishii EK, Macturk RH. Age-related changes in the prevalence of smell/taste problems among the United States adult population. Results of the 1994 Disability Supplement to the National Health Interview Survey (NHIS). Ann N Y Acad Sci 1998;855:716–22
6 Henkin RI, Bradley DF. Hypogeusia corrected by Ni++ and Zn++. Life Sci 1970;9:701–9
7 Yoshida S, Endo S, Tomita H. A double-blind study of the therapeutic efficacy of zinc gluconate on taste disorder. Auris Nasus Larynx 1991;18:153–61
8 Sakai F, Yoshida S, Endo S, Tomita H. Double-blind, placebo controlled trial of zinc picolinate for taste disorders. Acta Otolaryngol Suppl 2002;546:129–33
9 Mahajan SK, Prasad AS, Lambujon J, Abbasi AA, Briggs WA, McDonald FD. Improvement of uremic hypogeusia by zinc: a double-blind study. Am J Clin Nutr 1980;33:1517–21
10 Ripamonti C, Zecca E, Brunelli C, Fulfaro F, Villa S, Balzarini A et al. A randomised, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation. Cancer 1998;82:1938–45
11 Tomita H. Zinc in taste and smell disorders. In: Tomita H, ed. Trace Elements in Clinical Medicine. Tokyo: Springer-Verlag, 1990;1537
12 Pilch SM, Senti FR. Analysis of zinc data from the Second National Health and Nutrition Examination Survey (NHANESII). J Nutr 1985;115:1393–7
13 Burch RE, Sackin DA, Ursick JA, Jetton MM, Sullivan JF. Decreased taste and smell acuity in cirrhosis. Arch Intern Med 1978;138:743–6
14 Atkin-Thor E, Godderd BW, O'Nion J, Stephen RL, Kolff WJ. Hypogeusia and zinc depletion in chronic dialysis patients. Am J Clin Nutr 1978;31:1948–51
15 Matsuo S, Nakamoto M, Nishihara G, Yasunaga T, Matsuo K, Sakomi T. Impaired taste acuity in patients with diabetes mellitus on maintenance hemodialysis. Nephron Clin Pract 2003;94:4650
16 Solomons NW, Rosenberg IH, Sandstead HH, Vo-Khactu KP. Zinc deficiency in Crohn's disease. Digestion 1977;16:8795
17 Harris AM, Griffin SM. Postoperative taste and smell deficit after upper gastrointestinal cancer surgery – an unreported complication. J Surg Oncol 2003;82:147–52
18 Schelling J, Tetriault L, Lasaguna L, Davis M. Abnormal taste threshold in diabetics. Lancet 1965;i:508–12
19 Hardy SL, Brennand CP, Wyse BW. Taste thresholds of individuals with diabetes mellitus and of control subjects. J Am Diet Assoc 1981;79:286–9
20 Henkin RI, Larson AL, Powell RD. Hypogeusia, dysgeusia, hyposmia, and dysosmia following influenza-like infection. Ann Otol Rhinol Laryngol 1975;84:672–8
21 Tomita H, Ikeda M, Okuda Y. Basis and practice of clinical taste examinations. Auris Nasus Larynx 1986;13 (suppl 1):15
22 Ackerman BH, Kasbaker N. Disturbances of taste and smell induced by drugs. Pharmacotherapy 1997;17:482–96
23 Wickham RS, Rehwaldt M, Kefer C, Shott S, Abbas K, Glynn-Tucker E et al. Taste changes experienced by patients receiving chemotherapy. Oncol Nurs Forum 1999;26:697706
24 Itoh I, Ikui A, Ikeda M, Tomita H, Endo S. Taste disorder involving Hunter's glossitis following total gastrectomy. Acta Otolaryngol 2002;546:159–63
25 Onoda K, Ikeda M. Gustatory disturbance due to cerebrovascular disorder. Laryngoscope 1999;109:123–8
26 Henkin RI, Bradley DF. Regulation of taste acuity by thiols and metal ions. Proc Natl Acad Sci USA 1969;62:30–7
27 Hasegawa H, Tomita H. Assessment of taste disorders in rats by simultaneous study of the two-bottle preference test and abnormal ingesting behavior. Auris Nasus Larynx 1986;13(suppl 1):3341
28 Komai M, Goto T, Suzuki H, Takeda T, Furukawa Y. Zinc deficiency and taste dysfunction; contribution of carbonic anhydrase, a zinc-metalloenzyme, to normal taste sensation. Biofactors 2000;12:6570
29 Kobayashi T, Tomita H. Electron microscopic observation of vallate taste buds of zinc deficient rats with taste disturbance. Auris Nasus Larynx 1986;13(suppl 1):2531
30 Hambidge KH, Hambidge C, Jacobs M, Baum JD. Low levels of zinc in hair, anorexia, poor growth, and hypogeusia in children. Pediatr Res 1972;6:868–74
31 Henkin RI, Shechter PJ, Friedewald WT, Demets DL, Raff M. A double blind study of the effects of zinc sulfate on taste and smell dysfunction. Am J Med Sci 1976;272:285–99
32 Sekimoto K, Tomita H. Zinc chelation capacity of hypotensive agents causing taste disturbance. The Nihon University Journal of Medicine 1986;28:233–52
33 Yoshikawa T. Experimental study on drug-induced taste disorders in rats. The Nihon University Journal of Medicine 1997;39:353–67
34 Vallee BL, Wacker WEC, Bartholomay AF, Hoch FL. Zinc metabolism in hepatic dysfunction. II. Correlation of metabolic patterns with biochemical findings. New Engl J Med 1957;257:1055–65
35 Sullivan JF, Jetton MM, Burch RE. A zinc tolerance test. J Lab Clin Med 1979;93:485–92
36 Marumo F, Tsukamoto Y, Iwanami S, Kishimoto T, Yamagami S. Trace element concentrations in hair, fingernails and plasma of patients with chronic renal failure on hemodialysis and hemofiltration. Nephron 1984;38:267–72
37 Walter RM, Uriu-Hare JY, Olin KL, Oster MH, Anawalt BD, Critchfield JW et al. Copper, zinc, manganese, and magnesium status and complications of diabetes mellitus. Diabetes Care 1991;14:1050–6
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 1
Total number of PDF views: 13 *
Loading metrics...

Abstract views

Total abstract views: 180 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 21st October 2017. This data will be updated every 24 hours.