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Chemotherapy: United Kingdom National Multidisciplinary Guidelines

  • C G Kelly (a1)
Abstract
Abstract

This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. This paper summarises the role of chemotherapy in head and neck cancer management, recent advances and what the future holds for this modality.

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Copyright
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Corresponding author
Address for correspondence: Charles G Kelly, Northern Centre for Cancer Care and Newcastle University, Freeman Hospital, Newcastle upon Tyne, UK E-mail: Charles.Kelly@nuth.nhs.uk
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1The Department of Veterans Affairs Laryngeal Cancer Study Group. Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med 1991;324:1685–90

2 JP Pignon , A le Maitre , E Maillard , J Bourhis , M-NC. Group Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients. Radiother Oncol 2009;92:414

3 R Hitt , JJ Grau , A Lopez-Pousa , A Berrocal , C García-Girón , A Irigoyen A randomized phase III trial comparing induction chemotherapy followed by chemoradiotherapy versus chemoradiotherapy alone as treatment of unresectable head and neck cancer. Ann Oncol 2014;25:216–25

5 MR Posner , DM Hershock , CR Blajman , E Mickiewicz , E Winquist , V Gorbounova Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer. N Engl J Med 2007;357:1705–15

7 EE Cohen , TG Karrison , M Kocherginsky , J Mueller , R Egan , CH Huang Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer. J Clin Oncol 2014;32:2735–43

11 JA Bonner , PM Harari , J Giralt , N Azarnia , DM Shin , RB Cohen Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 2006;354:567–78

12 JA Bonner , PM Harari , J Giralt Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol 2010;11:21–8

13 SA Spencer , J Harris , RH Wheeler , M Machtay , C Schultz , W Spanos Final report of RTOG 9610, a multi-institutional trial of reirradiation and chemotherapy for unresectable recurrent squamous cell carcinoma of the head and neck. Head Neck 2008;30:281–8

14 A Argiris , Y Li , BA Murphy , CJ Langer , AA. Forastiere Outcome of elderly patients with recurrent or metastatic head and neck cancer treated with cisplatin-based chemotherapy. J Clin Oncol 2004;22:262–8

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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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