Skip to main content
×
Home
    • Aa
    • Aa

Chondrosarcomas of the skull base and temporal bone

  • L R Lustig (a1), J Sciubba (a2) and M J Holliday (a2)
Abstract
AbstractObjective:

To evaluate the clinical presentation and outcomes of treatment for patients with chondrosarcomas involving the skull base and temporal bone.

Study design:

Retrospective review.

Setting:

Tertiary medical centre.

Patients:

Cases of histologically confirmed chondrosarcoma involving the skull base and temporal bones.

Intervention:

Surgery.

Main outcome measures:

Demographic features of presenting patients; presenting symptoms and signs; surgical approach employed; use of post-operative radiation therapy; histological grade of tumour; and interval of post-operative follow up.

Results: Twelve patients were identified with chondrosarcomas involving the skull base, with post-operative follow up ranging from three to 33 years. The average age at presentation was 42 years. The most common presenting symptoms were diplopia, decreased visual acuity and headaches. Five of the 12 patients required multiple surgical procedures.

Conclusions:

Patients with chondrosarcoma involving the skull base and temporal bone may present in a variety of ways. Surgical resection, even subtotal, in combination with radiation therapy, can often provide good tumour control over many years for these rare tumours.

Copyright
Corresponding author
Address for correspondence: Dr Lawrence R Lustig, Associate Professor, Department of Otolaryngology – Head & Neck Surgery, 400 Parnassus Avenue, A746, Box 0342, San Francisco, CA 94143-0342, USA. E-mail: llustig@ohns.ucsf.edu
References
Hide All
1Hug E, Slater J. Proton radiation therapy for chordomas and chondrosarcomas of the skull base. Neurosurg Clin N Am 2000;11:627–38
2Berkmen Y, Blatt E. Cranial and intracranial cartilaginous tumours. Clin Radiol 1968;19:327–33
3Jaffe H. Tumours and Tumourous Conditions of the Bone and Joints. Philadelphia: Lea Ferbiger, 1958;314–40
4Rosenberg A, Nielsen P, Keel SB, Renard LG, Fitzek MM, Munzenrider JE et al. Chondrosarcomas of the base of skull. Am J Surg Path 1999;23:1370–8
5Dahlin D, Unni K. Giant cell tumor in bone tumors: General aspects and data on 8542 cases. In: Thomas C, ed. Osteoblastoma, 4th edn. Springfield, Illinois: McGraw-Hill, 1986;119–40
6Adegbite AB, McQueen JD, Paine KW, Rozdilsky B. Primary intracranial chondrosarcoma: a report of two cases. Neurosurgery 1985;17:490–4
7Coltrera MD, Googe PB, Harrist TJ, Hyams VJ, Schiller AL, Goodman ML. Chondrosarcoma of the temporal bone. Diagnosis and treatment of 13 cases and review of the literature. Cancer 1986;58:2689–96
8Naufal PM. Primary sarcomas of the temporal bone. Arch Otolaryngol 1973;98:4450
9Lau DP, Wharton SB, Antoun NM, Bottrill ID, Moffat DA. Chondrosarcoma of the petrous apex. Dilemmas in diagnosis and treatment. J Laryngol Otol 1997;111:368–71
10Seidman MD, Nichols RD, Raju UB, Mehta B, Levy HG. Extracranial skull base chondrosarcoma. Ear Nose Throat J 1989;68:626–32, 635
11Burkey BB, Hoffman HT, Baker SR, Thornton AF, McClatchey KD. Chondrosarcoma of the head and neck. Laryngoscope 1990;100:1301–5
12Brown E, Hug EB, Weber AL. Chondrosarcoma of the skull base. Neuroimaging Clin N Am 1994;4:529–41
13Weber A, Brown E, Hug E, Liebsch N. Cartilaginous tumors and chordomas of the cranial base. Otolaryngol Clin N Am 1995;28:453–71
14Korten A, ter Berg H, Spincemaille G, van der Laan R, Van de Wel A. Intracranial chondrosarcoma: review of the literature and report of 15 cases. J Neurol Neurosurg Psychiatry 1988;65:8892
15Munzenrider J, Liebsch N, Efird J. Chordomas and chondrosarcomas of the skull base: treatment with fractionated X-ray and proton radiotherapy. In: Johnson J, Didolkar M, eds. Head and Neck Cancer. New York, NY: Elsevier Science Publishers, 1993;649–54
16Koch BB, Karnell LH, Hoffman HT, Apostolakis LW, Robinson RA, Zhen W et al. National cancer database report on chondrosarcoma of the head and neck. Head Neck 2000;22:408–25
17Kveton JF, Brackmann DE, Glasscock ME 3rd, House WF, Hitselberger WE. Chondrosarcoma of the skull base. Otolaryngol Head Neck Surg 1986;94:2332
18Volpe NJ, Liebsch NJ, Munzenrider JE, Lessell S. Neuro-ophthalmologic findings in chordoma and chondrosarcoma of the skull base. Am J Ophthalmol 1993;115:97104
19Evans HL, Ayala AG, Romsdahl MM. Prognostic factors in chondrosarcoma of bone: a clinicopathologic analysis with emphasis on histologic grading. Cancer 1977;1:818–31
20Sheth DS, Yasko AW, Johnson ME, Ayala AG, Murray JA, Romsdahl MM. Chondrosarcoma of the pelvis. Prognostic factors for 67 patients treated with definitive surgery. Cancer 1996;78:745–50
21Fisch U. Infratemporal fossa approach to tumours of the temporal bone and base of the skull. J Laryngol Otol 1978;92:949–67
22Al-Mefty O, Fox JL, Rifai A, Smith RR. A combined infratemporal and posterior fossa approach for the removal of giant glomus tumors and chondrosarcomas. Surg Neurol 1987;28:423–31
23Blevins NH, Jackler RK, Kaplan MJ, Gutin PH. Combined transpetrosal-subtemporal craniotomy for clival tumors with extension into the posterior fossa. Laryngoscope 1995;105:975–82
24Megerian CA, Chiocca EA, McKenna MJ, Harsh GFT, Ojemann RG. The subtemporal-transpetrous approach for excision of petroclival tumors. Am J Otol 1996;17:773–9
25Sekhar LN, Schramm VL Jr, Jones NF. Subtemporal-preauricular infratemporal fossa approach to large lateral and posterior cranial base neoplasms. J Neurosurg 1987;67:488–99
26Samii M, Ammirati M. The combined supra-infratentorial pre-sigmoid sinus avenue to the petro-clival region. Surgical technique and clinical applications. Acta Neurochir (Wien) 1988;95:612
27Lalwani AK, Kaplan MJ, Gutin PH. The transsphenoethmoid approach to the sphenoid sinus and clivus. Neurosurgery 1992;31:1008–14
28Ammirati M, Ma J, Cheatham ML, Mei ZT, Bloch J, Becker DP. The mandibular swing-transcervical approach to the skull base: anatomical study. Technical note. J Neurosurg 1993;78:673–81
29Crockard HA, Steel T, Plowman N, Singh A, Crossman J, Revesz T et al. A multidisciplinary team approach to skull base chondrosarcomas. J Neurosurg 2001;95:175–83
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Full text views

Total number of HTML views: 1
Total number of PDF views: 22 *
Loading metrics...

Abstract views

Total abstract views: 117 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 21st October 2017. This data will be updated every 24 hours.