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    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Mosler, Katharina Coraux, Christelle Fragaki, Konstantina Zahm, Jean-Marie Bajolet, Odile Bessaci-Kabouya, Katia Puchelle, Edith Abély, Michel and Mauran, Pierre 2008. Feasibility of nasal epithelial brushing for the study of airway epithelial functions in CF infants. Journal of Cystic Fibrosis, Vol. 7, Issue. 1, p. 44.


    Loris, Remy Tielker, Denis Jaeger, Karl-Erich and Wyns, Lode 2003. Structural Basis of Carbohydrate Recognition by the Lectin LecB from Pseudomonas aeruginosa. Journal of Molecular Biology, Vol. 331, Issue. 4, p. 861.


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Cilia from a cystic fibrosis patient react to the ciliotoxic Pseudomonas aeruginosa II lectin in a similar manner to normal control cilia – a case report

  • Elizabeth C. Adam (a1), Dietlind U. Schumacher (a2) and Udo Schumacher (a1)
  • DOI: http://dx.doi.org/10.1017/S0022215100138551
  • Published online: 01 June 2007
Abstract
Abstract

The ciliary beat frequency measurements taken from a nasal polyp from a cystic fibrosis patient were similar to that of the control nasal polyps. The addition of a ciliotoxic lectin produced by Pseudomonas aeruginosa stopped the beating of the cilia as in the controls. This reaction could be blocked by the pre-incubation of the lectin with its inhibitor fucose. As in the control, the addition of fucose after the cilia had slowed resulted in a return to normal ciliary beating within 24 hours. This shows that the delta F508 CF mutation observed in this patient does not affect ciliary beating and suggests that treatment with fucose in the early stages of a Pseudomonas aeruginosa infection could be advantageous for cystic fibrosis patients.

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Corresponding author
Address for correspondence: E. C. Adam, Human Morphology, University of Southampton, Bassett Crescent East, Southampton SO16 7PX. Fax: +44 (0)1703 594433 email: ECA@soton.ac.uk
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

E. C. Adam , B. S. Mitchell , D. U. Schumacher , G. Grant , U. Schumacher (1997) Pseudomonas aeruginosa II lectin stops human ciliary beating: therapeutic implications of fucose. American Journal of Respiratory and Critical Care Medicine 155: 21022104.

S. De Bentzmann , P. Roger , E. Puchelle (1996) Pseudomonas aeruginosa adherence to remodelling respiratory epithelium. European Respiratory Journal 9: 21452150.

R. B. Fick , R. S. Baltimore , S. V. Squier , S. Y. Reynolds (1985) IgG proteolytic activity of Pseudomonas aeruginosa in cystic fibrosis. Journal of Infectious Diseases 151: 589598.

Y. H. Ko , M. Delannoy , P. L. Pederson (1997) Cystic fibrosis, lung infections, and a human tracheal antimicrobial peptide (hTAP). FEBS Letters 405: 200208.

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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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