Skip to main content
    • Aa
    • Aa

Cilia from a cystic fibrosis patient react to the ciliotoxic Pseudomonas aeruginosa II lectin in a similar manner to normal control cilia – a case report

  • Elizabeth C. Adam (a1), Dietlind U. Schumacher (a2) and Udo Schumacher (a1)

The ciliary beat frequency measurements taken from a nasal polyp from a cystic fibrosis patient were similar to that of the control nasal polyps. The addition of a ciliotoxic lectin produced by Pseudomonas aeruginosa stopped the beating of the cilia as in the controls. This reaction could be blocked by the pre-incubation of the lectin with its inhibitor fucose. As in the control, the addition of fucose after the cilia had slowed resulted in a return to normal ciliary beating within 24 hours. This shows that the delta F508 CF mutation observed in this patient does not affect ciliary beating and suggests that treatment with fucose in the early stages of a Pseudomonas aeruginosa infection could be advantageous for cystic fibrosis patients.

Corresponding author
Address for correspondence: E. C. Adam, Human Morphology, University of Southampton, Bassett Crescent East, Southampton SO16 7PX. Fax: +44 (0)1703 594433 email:
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

E. C. Adam , B. S. Mitchell , D. U. Schumacher , G. Grant , U. Schumacher (1997) Pseudomonas aeruginosa II lectin stops human ciliary beating: therapeutic implications of fucose. American Journal of Respiratory and Critical Care Medicine 155: 21022104.

S. De Bentzmann , P. Roger , E. Puchelle (1996) Pseudomonas aeruginosa adherence to remodelling respiratory epithelium. European Respiratory Journal 9: 21452150.

R. B. Fick , R. S. Baltimore , S. V. Squier , S. Y. Reynolds (1985) IgG proteolytic activity of Pseudomonas aeruginosa in cystic fibrosis. Journal of Infectious Diseases 151: 589598.

Y. H. Ko , M. Delannoy , P. L. Pederson (1997) Cystic fibrosis, lung infections, and a human tracheal antimicrobial peptide (hTAP). FEBS Letters 405: 200208.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *



Full text views

Total number of HTML views: 0
Total number of PDF views: 9 *
Loading metrics...

Abstract views

Total abstract views: 28 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 24th September 2017. This data will be updated every 24 hours.