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Clinicopathological features of mucoepidermoid carcinoma

Published online by Cambridge University Press:  22 January 2014

K Yamazaki ,
H Ohta ,
R Shodo ,
H Matsuyama  and
S Takahashi
K Yamazaki*
Affiliation:
Niigata Prefecture Head and Neck Malignant Tumour Registration Committee, Faculty of Medicine, Niigata University, Japan Department of Otorhinolaryngology, Faculty of Medicine, Niigata University, Japan
H Ohta
Affiliation:
Niigata Prefecture Head and Neck Malignant Tumour Registration Committee, Faculty of Medicine, Niigata University, Japan Department of Otorhinolaryngology, Faculty of Medicine, Niigata University, Japan
R Shodo
Affiliation:
Niigata Prefecture Head and Neck Malignant Tumour Registration Committee, Faculty of Medicine, Niigata University, Japan Department of Otorhinolaryngology, Faculty of Medicine, Niigata University, Japan
H Matsuyama
Affiliation:
Niigata Prefecture Head and Neck Malignant Tumour Registration Committee, Faculty of Medicine, Niigata University, Japan Department of Otorhinolaryngology, Faculty of Medicine, Niigata University, Japan
S Takahashi
Affiliation:
Niigata Prefecture Head and Neck Malignant Tumour Registration Committee, Faculty of Medicine, Niigata University, Japan Department of Otorhinolaryngology, Faculty of Medicine, Niigata University, Japan
*
Address for correspondence: Dr Keisuke Yamazaki, Department of Otorhinolaryngology, Faculty of Medicine, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata-shi 951-8510, Japan Fax: +81 025 227 0786 E-mail: bymyself@med.niigata-u.ac.jp
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Abstract

Objective:

We aimed to examine the clinical usefulness of a new World Health Organization classification scheme for salivary gland mucoepidermoid carcinoma, and to identify the factors most strongly associated with prognosis and outcome.

Methods:

The clinicopathological features of 45 patients who received treatment for mucoepidermoid carcinoma between 1986 and 2010 were retrospectively investigated.

Results:

The overall disease-specific 5-year survival rate was 81.8 per cent. The rate for patients with low-grade tumours (92.5 per cent) was significantly higher than that for patients with intermediate or high-grade tumours (52.2 per cent). Univariate analysis revealed that five factors were significantly associated with five-year survival: age, tumour stage classification, lymph node status, histological grade and treatment method. Four factors were significant in multivariate analysis: age, sex, tumour stage classification and lymph node status.

Conclusion:

The new World Health Organization classification was useful in predicting disease progression in patients with mucoepidermoid carcinoma. Patients with high-grade tumours or other prognostic factors positively associated with disease progression should be carefully evaluated and monitored.

Keywords

Carcinoma, MucoepidermoidWorld Health OrganizationPrognosis
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 128 , Issue 1 , January 2014 , pp. 91 - 95
Copyright
Copyright © JLO (1984) Limited 2014 

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