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Cochlear implantation in auditory neuropathy spectrum disorders: role of transtympanic electrically evoked auditory brainstem responses and serial neural response telemetry

Published online by Cambridge University Press:  20 May 2021

S N Dutt ,
A Kumar ,
A A Mittal ,
S Vadlamani  and
S K Gaur
S N Dutt
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Apollo Hospitals, Bangalore, India
A Kumar
Affiliation:
Audiology, Ashadeep ENT Centre, Bangalore, India
A A Mittal
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Apollo Hospitals, Bangalore, India
S Vadlamani*
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Apollo Hospitals, Bangalore, India
S K Gaur
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Apollo Hospitals, Bangalore, India
*
Author for correspondence: Dr Swathi Vadlamani, Department of Otorhinolaryngology, Head and Neck Surgery, 154/11, Apollo Hospitals, Bannerghatta Road (opposite IIM), Bangalore, India – 560076 E-mail: vhkswat@gmail.com
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Abstract

Objective

To evaluate the utility of pre-operative transtympanic electrically evoked auditory brainstem responses and post-operative neural response telemetry in auditory neuropathy spectrum disorder patients.

Methods

Four auditory neuropathy spectrum disorder patients who had undergone cochlear implantation and used it for more than one year were studied. All four patients underwent pre-operative transtympanic electrically evoked auditory brainstem response testing, intra-operative and post-operative (at 3, 6 and 12 months after switch-on) neural response telemetry, and out-patient cochlear implant electrically evoked auditory brainstem response testing (at 12 months).

Results

Patients with better waveforms on transtympanic electrically evoked auditory brainstem response testing showed superior performance after one year of implant use. Neural response telemetry and electrically evoked auditory brainstem response measures improved in all patients.

Conclusion

Inferences related to cochlear implantation outcomes can be based on the waveform of transtympanic electrically evoked auditory brainstem responses. Robust transtympanic electrically evoked auditory brainstem responses suggest better performance. Improvements in electrically evoked auditory brainstem responses and neural response telemetry over time indicate that electrical stimulation is favourable in auditory neuropathy spectrum disorder patients. These measures provide an objective way to monitor changes and progress in auditory pathways following cochlear implantation.

Keywords

Auditory NeuropathyCochlear ImplantationEvoked PotentialsAuditoryBrain StemTelemetry
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 135 , Issue 7 , July 2021 , pp. 602 - 609
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

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Footnotes

Dr S Vadlamani takes responsibility for the integrity of the content of the paper

References

Starr, A, Picton, TW, Sininger, Y, Hood, LJ, Berlin, CI. Auditory neuropathy. Brain 1996;119:741–53CrossRefGoogle ScholarPubMed
Starr, A, Sininger, Y, Winter, M, Derebery, MJ, Oba, S, Michalewski, HJ. Transient deafness due to temperature-sensitive auditory neuropathy. Ear Hear 1998;19:169–79CrossRefGoogle ScholarPubMed
Berlin, CI, Hood, LJ, Morlet, T, Wilensky, D, Li, L, Mattingly, KR et al. Multi-site diagnosis and management of 260 patients with auditory neuropathy/dys-synchrony (auditory neuropathy spectrum disorder). Int J Audiol 2010;49:30–43CrossRefGoogle Scholar
Starr, A, Sininger, YS, Pratt, H. The varieties of auditory neuropathy. J Basic Clin Physiol Pharmacol 2000;11:215–30CrossRefGoogle ScholarPubMed
Starr, A. Pathology and physiology of auditory neuropathy with a novel mutation in the MPZ gene (Tyr145->Ser). Brain 2003;126:1604–19CrossRefGoogle Scholar
Starr, A, Zeng, FG, Michalewski, HJ, Moser, T. Perspectives on auditory neuropathy: disorders of inner hair cell, auditory nerve, and their synapse. In: Dallos, P, Oertel, D, eds. The Senses: A Comprehensive Reference, vol 3. Amsterdam: Elsevier, 2008;397–412CrossRefGoogle Scholar
McMahon, CM, Patuzzi, RB, Gibson, WPR, Sanli, H. Frequency-specific electrocochleography indicates that presynaptic and postsynaptic mechanisms of auditory neuropathy exist. Ear Hear 2008;29:314–25CrossRefGoogle ScholarPubMed
Starr, A, Rance, G. Auditory neuropathy. In: Aminoff, MJ, Boller, F, Swaab, DF, eds. Handbook of Clinical Neurology. Amsterdam: Elsevier, 2015;495–508Google Scholar
Rance, G, Barker, EJ. Speech perception in children with auditory neuropathy/dyssynchrony managed with either hearing aids or cochlear implants. Otol Neurotol 2008;29:179–82CrossRefGoogle ScholarPubMed
Roush, P, Frymark, T, Venediktov, R, Wang, B. Audiologic management of auditory neuropathy spectrum disorder in children: a systematic review of the literature. Am J Audiol 2011;20:159–70CrossRefGoogle ScholarPubMed
Psarommatis, I, Riga, M, Douros, K, Koltsidopoulos, P, Douniadakis, D, Kapetanakis, I et al. Transient infantile auditory neuropathy and its clinical implications. Int J Pediatr Otorhinolaryngol 2006;70:1629–37CrossRefGoogle ScholarPubMed
Madden, C, Hilbert, L, Rutter, M, Greinwald, J, Choo, D. Pediatric cochlear implantation in auditory neuropathy. Otol Neurotol 2002;23:163–8CrossRefGoogle ScholarPubMed
Shallop, JK, Facer, GW, Peterson, A. Neural response telemetry with the Nucleus CI24M cochlear implant. Laryngoscope 1999;109:1755–9CrossRefGoogle ScholarPubMed
Breneman, AI, Gifford, RH, DeJong, MD. Cochlear implantation in children with auditory neuropathy spectrum disorder: long-term outcomes. J Am Acad Audiol 2012;23:5–17Google ScholarPubMed
Gibson, W, Sanli, H. The role of round window electrophysiological techniques in the selection of children for cochlear implants. In: Kim, CS, Chang, SO, Lim, D, eds. Advances in Oto-Rhino-Laryngology. Basel: Karger, 2000;148–51Google Scholar
Kim, AH, Kileny, PR, Arts, HA, El-Kashlan, HK, Telian, SA, Zwolan, TA. Role of electrically evoked auditory brainstem response in cochlear implantation of children with inner ear malformations. Otol Neurotol 2008;29:626–34CrossRefGoogle ScholarPubMed
Kileny, PR, Zwolan, TA. Pre-perioperative, transtympanic electrically evoked auditory brainstem response in children. Int J Audiol 2004;43(suppl 1):S16–21Google ScholarPubMed
Gardner-Berry, K, Gibson, WP, Sanli, H. Pre-operative testing of patients with neuropathy or dys-synchrony. Hear J 2005;58:24–5CrossRefGoogle Scholar
Archbold, S, Lutman, ME, Marshall, DH. Categories of auditory performance. Ann Otol Rhinol Laryngol Suppl 1995;166:312–14Google ScholarPubMed
Allen, MC, Nikolopoulos, TP, O'Donoghue, GM. Speech intelligibility in children after cochlear implantation. Am J Otol 1998;19:742–6Google ScholarPubMed
Pau, H, Gibson, WPR, Sanli, H. Trans-tympanic electric auditory brainstem response (TT-EABR): the importance of the positioning of the stimulating electrode. Cochlear Implants Int 2006;7:183–7CrossRefGoogle ScholarPubMed
Dutt, SN, Kumar, A. The methodology and electro-physiological classification of pre-operative trans-tympanic electrically-evoked auditory brainstem response (TT-EABR). Indian J Otolaryngol Head Neck Surg 2019;71:1–4CrossRefGoogle Scholar
Mason, JC, De Michele, A, Stevens, C, Ruth, RA, Hashisaki, GT. Cochlear implantation in patients with auditory neuropathy of varied etiologies. Laryngoscope 2003;113:45–9CrossRefGoogle ScholarPubMed
Miyamoto, RT, Kirk, KH, Renshaw, J, Hussain, D. Cochlear implantation in auditory neuropathy. Laryngoscope 1999;109:181–5CrossRefGoogle ScholarPubMed
Peterson, A, Shallop, J, Driscoll, C, Breneman, A, Babb, J, Stoeckel, R et al. Outcomes of cochlear implantation in children with auditory neuropathy. J Am Acad Audiol 2003;14:188–201Google ScholarPubMed
Harrison, RV, Gordon, KA, Papsin, BC, Negandhi, J, James, AL. Auditory neuropathy spectrum disorder (ANSD) and cochlear implantation. Int J Pediatr Otorhinolaryngol 2015;79:1980–7CrossRefGoogle ScholarPubMed
Gibson, WPR, Sanli, H. Auditory neuropathy: an update: Ear Hear 2007;28(2 suppl):102S–6SCrossRefGoogle ScholarPubMed
Al Shaikh, AM, Eldin, HE, Abusetta, A. Outcome of auditory neuropathy spectrum disorder after cochlear implantation. J Child Dev Disord 2016;2:3CrossRefGoogle Scholar
Chisholm, K, Gibbons, A, Psarros, C, Bate, K, Gardner-Berry, K. Longitudinal outcomes of early implantation in children with auditory neuropathy spectrum disorder (ANSD). Cochlear Implants Int 2010;11(supp1):169–75CrossRefGoogle Scholar
Jeon, JH, Bae, MR, Song, MH, Noh, SH, Choi, KH, Choi, JY. Relationship between electrically evoked auditory brainstem response and auditory performance after cochlear implant in patients with auditory neuropathy spectrum disorder. Otol Neurotol 2013;34:1261–6CrossRefGoogle ScholarPubMed
Cinar, BC, Yarali, M, Atay, G, Bajin, MD, Sennaroglu, G, Sennaroglu, L. The role of eABR with intracochlear test electrode in decision making between cochlear and brainstem implants: preliminary results. Eur Arch Otorhinolaryngol 2017;274:3315–26CrossRefGoogle ScholarPubMed