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Current status and clinical association of beta-catenin with juvenile nasopharyngeal angiofibroma

  • A Mishra (a1), V Singh (a1), V Verma (a1), S Pandey (a2), R Trivedi (a3), H P Singh (a1), S Kumar (a1), R C Dwivedi (a4) and S C Mishra (a5)...
Abstract
Abstract Objective:

A possible role of the APC/beta-catenin pathway in the pathogenesis of sporadic juvenile nasopharyngeal angiofibroma has been suggested. This paper presents its current status and clinical association in our patients.

Method:

A prospective observational study was conducted at King George Medical University and Central Drug Research Institute, in Lucknow, India. Western blot analysis was undertaken in 16 cases to examine beta-catenin expression. The clinical details were recorded along with follow up observations, to determine associations.

Results:

Up-regulation of beta-catenin expression was seen in 69 per cent of cases. The clinical variables did not reveal significant differences between patients with extremes of expression (extreme under- vs over-expression). However, absent expression was shown exclusively in young adults aged over 18 years, while enhanced expression was associated with an altered facial profile.

Conclusion:

Although a beta-catenin association was seen in a subset of our sporadic juvenile nasopharyngeal angiofibroma cases, its expression was not homogeneous. This is in contrast to the Western literature that suggests a universal (homogenous) enhanced expression in the majority. Hence, further research is required to better define its molecular cascade.

Copyright
Corresponding author
Address for correspondence: Dr Anupam Mishra, Department of Otorhinolaryngology, King George Medical University, Lucknow, India E-mail: amishra_ent@yahoo.com
References
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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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