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Can curcumin modulate allergic rhinitis in rats?

  • M Acar (a1), N Bayar Muluk (a2), S Yigitaslan (a3), B P Cengiz (a4), P Shojaolsadati (a5), H Karimkhani (a6), S Ada (a7), M Berkoz (a8) and C Cingi (a9)...



This study aimed to explore the effects of curcumin on experimental allergic rhinitis in rats.


Twenty-eight male Wistar albino rats were randomly divided into four groups: a control group; a group in which allergic rhinitis was induced and no treatment given; a group in which allergic rhinitis was induced followed by treatment with azelastine hydrochloride on days 21–28; and a group in which allergic rhinitis was induced followed by treatment with curcumin on days 21–28. Allergy symptoms and histopathological features of the nasal mucosa were examined.


The sneezing and nasal congestion scores were higher in the azelastine and curcumin treatment groups than in the control group. Histopathological examination showed focal goblet cell metaplasia on the epithelial surface in the azelastine group. In the curcumin group, there was a decrease in goblet cell metaplasia in the epithelium, decreased inflammatory cell infiltration and vascular proliferation in the lamina propria.


Curcumin is an effective treatment for experimentally induced allergic rhinitis in rats.


Corresponding author

Address for correspondence: Dr Nuray Bayar Muluk, Birlik Mahallesi, Zirvekent 2. Etap Sitesi, C-3 blok, No: 62/43, 06610 Çankaya / ANKARA, Turkey Fax: +90 312 4964073 E-mail:


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1 Owaga, EE, Mpondab, J, Nyang'injac, RA. Nutrigenomic approach in understanding the antiallergic effects of curcumin. Asian Journal of Biomedical and Pharmaceutical Sciences 2014;4:15
2 Srivastava, RM, Singh, S, Dubey, SK, Misra, K, Khar, A. Immunomodulatory and therapeutic activity of curcumin. Int Immunopharmacol 2011;11:331–41
3 Bousquet, J, Van Cauwenberge, P, Khaltaev, N. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 2001;108(suppl 5):S147S334
4 Sih, T, Mion, O. Allergic rhinitis in the child and associated comorbidities. Pediatr Allergy Immunol 2010;21:e107e113
5 Vinke, JG, KleinJan, A, Severijnen, LW, Hoeve, LJ, Fokkens, WJ. Differences in nasal cellular infiltrates between allergic children and age-matched controls. Eur Respir J 1999;13:797803
6 Kurup, VP, Barrios, CS. Immunomodulatory effects of curcumin in allergy. Mol Nutr Food Res 2008;52:1031–9
7 Bozdemir, K, Şahin, E, Altintoprak, N, Muluk, NB, Cengiz, BP, Acar, M et al. Is resveratrol therapeutic when used to treat allergic rhinitisinitis in rats? Clin Invest Med 2016;39: E6372
8 Hancı, D, Altun, H, Çetinkaya, EA, Muluk, NB, Cengiz, BP, Cingi, C. Cinnamaldehyde is an effective anti-inflammatory agent for treatment of allergic rhinitis in a rat model. Int J Pediatr Otorhinolaryngol 2016;84:81–7
9 Xu, YY, Liu, X, Dai, LB, Zhou, SH. Effect of Tong Qiao drops on the expression of eotaxin, IL-13 in the nasal mucosa of rats with allergic rhinitis. J Chin Med Assoc 2012;75:524–9
10 Tsumuro, T, Ogawa, M, Minami, K, Takubo, M, Rahman, A, Fujii, Y et al. Effects of mometasone furoate on a rat allergic rhinitis model. Eur J Pharmacol 2005;524:155–8
11 Mizutani, N, Nabe, T, Takenaka, H, Kohno, S. Acquired nasal hyperresponsiveness aggravates antigen-induced rhinitis in the guinea pig. J Pharmacol Sci 2003;93:437–45
12 Brozmanová, M, Calkovský, V, Plevková, J, Bartos, V, Plank, L, Tatár, M. Early and late allergic phase related cough response in sensitized guinea pigs with experimental allergic rhinitis. Physiol Res 2006;55:577–84
13 Tirkey, N, Kaur, G, Vij, G, Chopra, K. Curcumin, a diferuloylmethane, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys. BMC Pharmacol 2005;5:15
14 Bahekar, PC, Shah, JH, Ayer, UB, Mandhane, SN, Thennati, R. Validation of guinea pig model of allergic rhinitis by oral and topical drugs. Int Immunopharmacol 2008;8:1540–51
15 Bengmark, S. Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipoxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases. JPEN J Parenter Enteral Nutr 2006;30:4551
16 Surh, YJ, Chun, KS, Cha, HH, Han, SS, Keum, YS, Park, KK et al. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Res 2001;480–481:243–68
17 Wallace, JM. Nutritional and botanical modulation of the inflammatory cascade – eicosanoids, cyclooxygenases, and lipoxygenases--as an adjunct in cancer therapy. Integr Cancer Ther 2002;1:737; discussion 37
18 Jovanovic, SV, Boone, CW, Steenken, S, Trinoga, M, Kaskey, RB. How curcumin works preferentially with water soluble antioxidants. J Am Chem Soc 2001;123:3064–8
19 Kang, BY, Song, YJ, Kim, KM, Choe, YK, Hwang, SY, Kim, TS. Curcumin inhibits Th1 cytokine profile in CD4+ T cells by suppressing interleukin-12 production in macrophages. Br J Pharmacol 1999;128:380–4
20 Stolina, M, Sharma, S, Lin, Y, Dohadwala, M, Gardner, B, Luo, J et al. Specific inhibition of cyclooxygenase-2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis. J Immunol 2000;164:361–70
21 Ram, A, Das, M, Ghosh, B. Curcumin attenuates allergen-induced hyperresponsiveness in sensitized guinea pigs. Biol Pharm Bull 2003;26:1021–4
22 Pulla Reddy, AC, Sudharshan, E, Appu Rao, AG, Lokesh, BR. Interactions of curcumin with human serum albumin: a spectroscopic study. Lipids 1999;34:1025–9
23 Choi, YH, Yan, GH, Chai, OH, Song, CH. Inhibitory effects of curcumin on passive cutaneous anaphylactoid response and compound 48/80-induced mast cell activation. Anat Cell Biol 2010;43:3643
24 Thakare, VN, Osama, M, Naik, SR. Therapeutic potential of curcumin in experimentally induced allergic rhinitis in guinea pigs. Int Immunopharmacol 2013;17:1825
25 Baek, OS, Kang, OH, Choi, YA, Choi, SC, Kim, TH, Nah, YH et al. Curcumin inhibits protease-activated receptor-2 and-4-mediated mast cell activation. Clin Chim Acta 2003;338:135–41
26 Lee, JH, Kim, JW, Ko, NY, Mun, SH, Her, E, Kim, BK et al. Curcumin, a constituent of curry, suppresses IgE-mediated allergic response and mast cell activation at the level of Syk. J Allergy Clin Immunol 2008;121:1225–31
27 Kalesnikoff, J, Galli, SJ. New developments in mast cell biology. Nat Immunol 2008;9:1215–23
28 Aggarwal, BB, Harikumar, KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol 2009;41:4059
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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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