Skip to main content
×
×
Home

Do patients with p16-positive oropharyngeal squamous cell carcinoma get more bone metastasis than p16-negative patients?

  • A S Harris (a1), R G Thomas (a1) and C D Passant (a1)
Abstract
Background:

Oropharyngeal squamous cell carcinoma is thought to rarely metastasise to bone. This study hypothesised that in p16-positive disease there is a significant incidence of bony metastasis.

Methods:

This was an ambispective cohort review. All patients with oropharyngeal squamous cell carcinoma diagnosed and treated at one centre were included.

Results:

A total of 180 consecutive patients were identified over 5 years. Fifteen patients were excluded because of lack of p16 status, none of whom had bony metastasis. The final analysis included 165 patients: 48 (29.09 per cent) in the p16-negative group and 117 (70.91 per cent) in the p16-positive group. Ten patients (8.55 per cent) in the p16-positive group developed bony metastasis, compared with zero in the p16-negative group; this difference was statistically significant (p = 0.036).

Conclusion:

Expression of p16 was associated with an increased incidence in bony metastasis in this cohort. This is the first study to explore this specific question.

Copyright
Corresponding author
Address for correspondence: Mr Andrew S Harris, Ear, Nose and Throat Department, Royal Gwent Hospital, Cardiff Road, Newport NP20 2UB, Wales, UK E-mail: drewharris@doctors.org.uk
Footnotes
Hide All

Presented as a poster at the British Association of Head and Neck Oncology (‘BAHNO’) Annual Scientific Meeting, 12 May 2017, London, UK.

Footnotes
References
Hide All
1Takes, RP, Rinaldo, A, Silver, CE, Haigentz, M Jr, Woolgar, JA, Triantafyllou, A et al. Distant metastases from head and neck squamous cell carcinoma. Part I. Basic aspects. Oral Oncol 2012;48:775–9.
2Ferlito, A, Shaha, AR, Silver, CE, Rinaldo, A, Mondin, V. Incidence and sites of distant metastases from head and neck cancer. ORL J Otorhinolaryngol Relat Spec 2001;63:202–7.
3Kowalski, LP, Carvalho, AL, Priante, AV, Magrin, J. Predictive factors for distant metastasis from oral and oropharyngeal squamous cell carcinoma. Oral Oncol 2005;41:534–41.
4Gooi, Z, Chan, JY, Fakhry, C. The epidemiology of the human papillomavirus related to oropharyngeal head and neck cancer. Laryngoscope 2016;126:894900.
5Wittekindt, C, Gültekin, E, Weissenborn, SJ, Dienes, HP, Pfister, HJ, Klussmann, JP. Expression of p16 protein is associated with human papillomavirus status in tonsillar carcinomas and has implications on survival. Adv Otorhinolaryngol 2005;62:7280.
6Huang, SH, Perez-Ordonez, B, Liu, FF, Waldron, J, Ringash, J, Irish, J et al. Atypical clinical behavior of p16-confirmed HPV-related oropharyngeal squamous cell carcinoma treated with radical radiotherapy. Int J Radiat Oncol Biol Phys 2012;82:276–83.
7Müller, S, Khuri, FR, Kono, SA, Beitler, JJ, Shin, DM, Saba, NF. HPV positive squamous cell carcinoma of the oropharynx. Are we observing an unusual pattern of metastases? Head Neck Pathol 2012;6:336–44.
8Haigentz, M Jr, Hartl, DM, Silver, CE, Langendijk, JA, Strojan, P, Paleri, V et al. Distant metastases from head and neck squamous cell carcinoma. Part III. Treatment. Oral Oncol 2012;48:787–93.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed