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Endotoxic damage to the stria vascularis: the pathogenesis of sensorineural hearing loss secondary to otitis media?

Published online by Cambridge University Press:  29 June 2007

Yangchun Guo ,
Yiqin Wu ,
Wenlie Chen  and
Jizhen Lin
Yangchun Guo*
Affiliation:
Department of Otolaryngology, Union Hospital, Fuzhou, China.
Yiqin Wu
Affiliation:
Union Hospital and the Department of Electron Microscopy, Fujian Medical College, Fuzhou, China.
Wenlie Chen
Affiliation:
Union Hospital and the Department of Electron Microscopy, Fujian Medical College, Fuzhou, China.
Jizhen Lin
Affiliation:
Department of Otolaryngology, Union Hospital, Fuzhou, China.
*
Dr Yangchun Guo, Department of Otolaryngology, Union Hospital, Xinquan Road, Fuzhou 350001. PR China.
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Abstract

This study presents animal experiments on endotoxin (lipopolysaccharides: LPS) damage to the inner ear with special reference to the stria vascularis. The experimental group animals (albino guinea pigs) were injected with LPS into the perilymphatic space. Pyrogen-free saline (PFS) was injected into the control group. Strial structural evaluation and hearing tests were carried out before and one, three and five days after treatment. In PFS-treated (control) ears, no significant change was found either in hearing or structure. However, thresholds of Nl/Pl were elevated and latencies prolonged in LPS-treated ears. They had severe strial damage mainly to the cellular organelles. The mitochondria became swollen with a disordered, broken, degenerated or absent crest. Secondary lysosomes and autophagosomes increased in number with the presence of medulative inclusions. Na+-K+-ATPase reactant was obviously diminished. It is concluded that LPS-induced strial ototoxicityproduces ion imbalance, causing changesin endolymph composition and energy failure in the organ of Corti and is also responsible for the pathogenesis of inner ear sequelae secondary to otitis media.

Keywords

EndotoxinsLabyrinthtoxicityOtitis mediaHearing losssensorineural
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 108 , Issue 4 , April 1994 , pp. 310 - 313
Copyright
Copyright © JLO (1984) Limited 1994

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References

Bernstein, J. M., Praino, P. D., Neter, E. (1990) Detection of endotoxin in ear specimens from patient with otitis media by means of limulus amebocyte test. Canadian Journal of Microbiology 26(6): 645–648.Google Scholar
Cusimano, R, Cocita, V. C, D'Amico, A. (1989) Sensorineural hearing loss in chronic otitis media. Journal of Laryngology andOtology 103(2): 158–163.Google Scholar
Darrow, D. H., Keithley, E. M, Harris, J. P. (1992) Effects of bacterial endotoxin applied to the guinea pig cochleas. Laryngoscope 102(6): 683–688.Google Scholar
DeMaria, T. F. (1988) Endotoxin and otitis media. Annals of Otology, Rhinology and Laryngology 97 (Suppl. 132): 31–33.CrossRefGoogle Scholar
Levine, B. A., Shelton, C, Berliner, K. I., Sheehy, J. L. (1989) Sensorineural hearing loss in chronic otitis media. Is it clinically significant? Archives of Otolaryngology, Head and Neck Surgery 115(7): 814–816.Google Scholar
Lin, J-Z., Xu, G-Y., Li, G-F. (1988) Experimental study on endotoxin- induced damage to the organ of Corti in guinea pigs. Chinese Journal of Clinical Otolaryngology 2(4): 194–197.Google Scholar
Lin, J-Z., Wu, Y-Q., Xu, G-Y. (1989) Endotoxic damage to the neural components in the organ of Corti. Chinese Journal of Medicine 69(12): 674–676.Google Scholar
Konishi, T. (1970) Effect of ouabain on cochlear potentials and endolymph composition in guinea pigs. Ada Otolaryngologica 69(2): 192–196.Google Scholar
Nakai, Y., Morimoto, A., Chang, K-O., Yamanaka, M., Nishisato, K. (1980) Inner ear damage induced by bacterial endotoxin. A rchives of Otolaryngology 106: 209–220.Google Scholar
Paparella, M. M., Brady, D. R., Hoel, R. (1970) Sensorineural hearing loss in otitis media and mastoiditis. Transactions of American Academy of Ophthalmology and tolaryngology 74(2): 108–115.Google Scholar