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Expression of “a disintegrin and metalloproteinase-33” (ADAM-33) protein in laryngeal squamous cell carcinoma

Published online by Cambridge University Press:  02 March 2012

O Topal ,
H Erinanc ,
C Ozer ,
E T Canpolat ,
S B Celik  and
S S Erbek
O Topal*
Affiliation:
Department of Otolaryngology, Faculty of Medicine, Başkent University, Ankara, Turkey
H Erinanc
Affiliation:
Department of Pathology, Faculty of Medicine, Başkent University, Ankara, Turkey
C Ozer
Affiliation:
Department of Otolaryngology, Faculty of Medicine, Başkent University, Ankara, Turkey
E T Canpolat
Affiliation:
Department of Pathology, Faculty of Medicine, Başkent University, Ankara, Turkey
S B Celik
Affiliation:
Department of Otolaryngology, Faculty of Medicine, Başkent University, Ankara, Turkey
S S Erbek
Affiliation:
Department of Otolaryngology, Faculty of Medicine, Başkent University, Ankara, Turkey
*
Address for correspondence: Dr Ozgul Topal, Department of Otolaryngology, Başkent University Konya Research and Teaching Center, Saray Caddesi No 1 Selcuklu, Ankara, 42080Turkey Fax: +90 332 2570637 E-mail: ozgultopal75@yahoo.com
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Abstract

Objective:

A disintegrin and metalloproteinase domain containing protein 33 (also known as ADAM-33) is a member of a matrix metalloproteinase family which mediates extracellular matrix remodelling and changes in cellular adhesion. This study aimed to evaluate expression of this protein in laryngeal squamous cell carcinoma, and to determine its correlation with patients' clinicopathological characteristics.

Subjects and methods:

Forty paraffin blocks of laryngeal carcinoma underwent immunohistochemical staining to detect “a disintegrin and metalloproteinase-33” expression. Case records were reviewed to determine patient characteristics.

Results:

All epithelial, vascular and stromal staining scores were significantly increased in tumour tissue compared with controls (p < 0.001). However, patients' clinical characteristics at the time of diagnosis, and their disease extent, did not correlate significantly with the immunohistochemical staining scores.

Conclusion:

This study suggests that increased expression of “a disintegrin and metalloproteinase-33” may play a role in the pathogenesis of laryngeal carcinoma.

Keywords

Laryngeal NeoplasmsCarcinomaA Disintegrin And Metalloproteinase-33 ProteinHuman
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 126 , Issue 5 , May 2012 , pp. 511 - 515
Copyright
Copyright © JLO (1984) Limited 2012

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