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Idiopathic midline destructive disease – does it exist?

Published online by Cambridge University Press:  29 June 2007

T. H. W. Barker  and
A. A. Hosni
T. H. W. Barker*
Affiliation:
Department of Histopathology, Norfolk and Norwich Hospital, Norwich, Peterborough Hospital, Peterborough, UK.
A. A. Hosni
Affiliation:
Department of Otolaryngology, Peterborough Hospital, Peterborough, UK.
*
Address for correspondence: T. H. W. Barker, F.R.C.Path., Department of Histopathology, Norfolk and Norwich Health Care NHS Trust, Brunswick Road, Norwich NR1 3SR.
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Abstract

There is controversy whether idiopathic mid-line destructive disease remains a valid entity, some authors considering that such cases are unrecognized malignant lymphoma or Wegener's disease. A case is presented in which numerous nasal biopsies over several years failed to show evidence of either lymphoma or Wegener's disease. Molecular genetic analysis of archival tissue did not demonstrate a monoclonal lymphoid population. It is proposed that idiopathic mid-line destructive disease remains a valid description in a small number of cases.

Keywords

Granuloma, lethal mid-lineMalignant lymphomaWegener's disease
Type
Pathology in Focus
Information
The Journal of Laryngology & Otology , Volume 112 , Issue 3 , March 1998 , pp. 307 - 309
Copyright
Copyright © JLO (1984) Limited 1998

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