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In vitro activities of fluconazole, itraconazole and voriconazole against otomycotic fungal pathogens

  • G Yenişehirli (a1), Y Bulut (a1), M Güven (a2) and E Günday (a1)

Abstract

Objective:

To determine the causative pathogens of otomycosis, and to evaluate the in vitro activity of antifungal agents against these pathogens.

Materials and methods:

A total of 96 fungal isolate were taken from 92 patients suspected of otomycosis. The in vitro activity of fluconazole, itraconazole and voriconazole against otomycotic pathogens was tested using the E-test method.

Results:

The most common pathogen was Aspergillus fumigatus (40.6 per cent), followed by A niger (35.4 per cent), A flavus (12.5 per cent) and Candida albicans (11.5 per cent). All Aspergillus species were found to be resistant to fluconazole (minimum inhibitory concentration ≥256 µg/ml). The mean minimum inhibitory concentrations of voriconazole for A fumigatus, A niger, A flavus and C albicans were significantly lower than those of itraconazole for the same pathogens.

Conclusion:

This study found that the most common otomycotic fungal pathogen was A fumigatus, and that voriconazole had more potent in vitro activity than itraconazole against all Aspergillus species as well as against C albicans.

Copyright

Corresponding author

Address for correspondence: Dr Gülgün Yenişehirli, Gaziosmanpaşa University, Faculty of Medicine, Department of Microbiology and Clinical Microbiology, 60100 Tokat, Turkey. Fax: +90 356 2133176 E-mail: gulguny@gop.edu.tr

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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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