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Intranasal Helicobacter pylori infection in patients with chronic rhinosinusitis with polyposis

  • N Siupsinskiene (a1) (a2), I Katutiene (a3), V Jonikiene (a3), D Janciauskas (a4) and S Vaitkus (a2)...

To determine the prevalence of Helicobacter pylori infection in nasal biopsy specimens from patients with chronic rhinosinusitis with polyposis versus control patients, and to assess the correlations between H pylori infection identified in the nasal tissue and patients’ sociodemographic data and reflux-related symptoms and signs.


Nasal biopsy samples were taken from 75 adult patients who underwent nasal surgery for chronic rhinosinusitis with polyposis (clinical group, n = 45) and a deviated septum (control group, n = 30). H pylori infection was identified using histochemical and rapid urease tests.


The prevalence of intranasal H pylori infection was significantly higher in the clinical group (28.9 per cent) compared to the control group (3.3 per cent) (p = 0.005). A significant yet weak association was found between positive H pylori status and laryngopharyngeal reflux related hypertrophy of the posterior commissure of the larynx. No other correlations reached statistical significance.


H pylori infection is potentially related to chronic rhinosinusitis with polyposis. Further research is needed to clarify the role of H pylori as a risk factor for the development of sinonasal diseases and to examine its link with laryngopharyngeal reflux.

Corresponding author
Author for correspondence: Habil. Dr Nora Siupsinskiene, Department of Otolaryngology, Academy of Medicine, Lithuanian University of Health Sciences, Eiveniu 2, Kaunas LT-50009, Lithuania E-mail: Fax: +370 37 326862
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Habil. Dr N Siupsinskiene takes responsibility for the integrity of the content of the paper

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1Ozdek, A, Cirak, MY, Samim, E, Bayiz, U, Safak, MA, Turet, S. A possible role of Helicobacter pylori in chronic rhinosinusitis: a preliminary report. Laryngoscope 2003;113:679–82
2Kariya, S, Okano, M, Nishizaki, K. An association between Helicobacter pylori and upper respiratory tract disease: fact or fiction? World J Gastroenterol 2014;20:1470–84
3Yemisen, M, Mete, B, Kanbay, A, Balkan, II, Ozaras, R. The role of Helicobacter pylori in upper respiratory system infections: is it more than colonization? Curr Infect Dis Rep 2012;14:128–36
4Kurtaran, H, Uyar, ME, Kasapoglu, B, Turkay, C, Yilmaz, T, Akcay, A et al. Role of Helicobacter pylori in pathogenesis of upper respiratory system diseases. J Natl Med Assoc 2008;100:1224–30
5Siupsinskiene, N, Katutiene, I, Jonikiene, V, Janciauskas, D, Vaitkus, S. Helicobacter pylori in the tonsillar tissue: a possible association with chronic tonsillitis and laryngopharyngeal reflux. J Laryngol Otol 2017;131:549–56
6Siupsinskiene, N, Jurgutaviciute, V, Katutiene, I, Janciauskas, D, Vaitkus, S, Adamonis, K. Helicobacter pylori infection in laryngeal diseases. Eur Arch Otorhinolaryngol 2013;270:2283–8
7Malfertheiner, P, Megraud, F, O'Morain, CA, Gilbert, JP, Kuipers, EJ, Axon, AT et al. Management of Helicobacter pylori infection—the Maastricht V/Florence Consensus Report. Gut 2017;66:630
8Hagymási, K, Tulassay, Z. Helicobacter pylori infection: new pathogenetic and clinical aspects. World J Gastroenterol 2014;20:6386–99
9Katra, R, Kabelka, Z, Jurovcik, M, Hradsky, O, Kraus, J, Pavlik, E et al. Pilot study: association between Helicobacter pylori in adenoid hyperplasia and reflux episodes detected by multiple intraluminal impedance in children. Int J Pediatr Otorhinolaryngol 2014;78:1243–9
10Morinaka, S, Ichimiya, M, Nakamura, H. Detection of Helicobacter pylori in nasal and maxillary sinus specimens from patients with chronic sinusitis. Laryngoscope 2003;113:1557–63
11Bansal, D, Sharma, S, Agarwal, S, Saha, RN. Detection of Helicobacter pylori in nasal polyps. Head Neck Pathol 2016;10:306–13
12Belafsky, PC, Postma, GN, Amin, MR, Koufman, JA. Symptoms and findings of laryngopharyngeal reflux. Ear Nose Throat J 2002;81:1013
13Belafsky, PC, Postma, GN, Koufman, JA. The validity and reliability of the Reflux Finding Score (RFS). Laryngoscope 2001;111:1313–17
14Jančiauskas, D. Histomorphological Changes of Gastric Mucosa in Functional Dyspepsia Patients and their Dynamics after Treatment with the Natural Antioxidant Astaxanthin. Kaunas: Kaunas Medical University, 2010
15Tseng, CA, Wang, WM, Wu, DC. Comparison of the clinical feasibility of three rapid urease tests in the diagnosis of Helicobacter pylori infection. Dig Dis Sci 2000;50:449–52
16Cvorovic, L, Brajovic, D, Strbac, M, Milutinovic, Z, Cvorovic, V. Detection of Helicobacter pylori in nasal polyps: preliminary report. J Otolaryngol Head Neck Surg 2008;37:192–5
17Koc, C, Arikan, OK, Atasoy, P, Aksoy, A. Prevalence of Helicobacter pylori in patients with nasal polyps: a preliminary report. Laryngoscope 2004;114:1941–4
18Včeva, A, Danić, D, Včev, A, Birtiċ, D, Mikalj, H, Zubčiċ, et al. The significance of Helicobacter pylori in patients with nasal polyposis. Med Glas (Zenica) 2012;9:281–6
19Noorbakhsh, S, Tabatabaei, A, Farhadi, M, Shamshiri, AR. Helicobacter pylori-DNA in nasal polyp tissues in compare with inferior nasal turbinate tissues: a case-control study in Tehran, Iran. J Infect Dis Immun 2011;3:73–8
20Burduk, PK, Kaczmarek, A, Budzynska, A, Kazmierczak, W, Gospodarek, E. Detection of Helicobacter pylori and cagA gene in nasal polyps and benign laryngeal diseases. Arch Med Res 2011;42:686–9
21Nikakhlagh, S, Samarbafzadeh, AR, Jahani, M, Poostchi, H, Kayedani, GA, Naghashpoor, M et al. Determining the role of Helicobacter pylori in chronic sinus infections using the polymerase chain reaction. Jundishapur J Microbiol 2015;8:e20783
22Jelavic, B, Grgić, M, Cupić, H, Kordić, M, Vasilj, M, Baudoin, T. Prognostic value of Helicobacter pylori sinonasal colonization for efficacy of endoscopic sinus surgery. Eur Arch Otorhinolaryngol 2012;269:2197–202
23Rook, GA. The changing microbial environment and chronic inflammatory disorders. Allergy Asthma Clin Immunol 2008;4:117–24
24Ozyurt, M, Gungor, A, Ergunay, K, Cekin, E, Erkul, E, Haznedaroglu, T. Real-time PCR detection of Helicobacter pylori and virulence-associated cagA in nasal polyps and laryngeal disorders. Otolaryngol Head Neck Surg 2009;141:131–5
25Dinis, PB, Subtil, J. Helicobacter pylori and laryngopharyngeal reflux in chronic rhinosinusitis. Otolaryngol Head Neck Surg 2006;134:6772
26Sella, GC, Tamashiro, E, Anselmo-Lima, WT, Valera, FC. Relation between chronic rhinosinusitis and gastroesophageal reflux in adults: systematic review. Braz J Otorhinolaryngol 2017;83:356–63
27Wong, IW, Omari, TI, Myers, JC, Rees, G, Nair, SB, Jamieson, GG et al. Nasopharyngeal pH monitoring in chronic sinusitis patients using a novel four channel probe. Laryngoscope 2004;114:1582–5
28Campbell, R, Kilty, SJ, Hutton, B, Bonaparte, JP. The role of Helicobacter pylori in laryngopharyngeal reflux. Otolaryngol Head Neck Surg 2017;156:255–62
29DelGaudio, JM. Direct nasopharyngeal reflux of gastric acid is a contributing factor in refractory chronic rhinosinusitis. Laryngoscope 2005;115:946–57
30Nemati, S, Mojtahedi, A, Naghavi, SE, Banan, R, Zia, F. Investigating Helicobacter pylori in nasal polyposis using polymerase chain reaction, urease test and culture. Eur Arch Otorhinolaryngol 2012;269:1457–61
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  • EISSN: 1748-5460
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