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Laryngeal edema as the only symptom of hypersenitivity to salicylic acid and other substances

  • G. Hillerdal (a1) and H. Lindholm (a2)

Idiosyncrasy to salicylic acid and related substances is well known, the most common symptoms being asthma, rhinorrhea and urticaria. We here describe two cases whose only symptoms were hoarseness and in which inspection revealed laryngeal edema when the patients ingested any of these substances. In cases of chronic recurring hoarseness, a history should be taken with respect to such hypersensitivity and suspect cases should be challenged, since a strict diet may improve the symptoms.

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G. A. Settipane , and R. K. Pudupakkam (1975) Aspirin intolerance. III. Subtypes, familial occurrence and cross-reactivity with tartrazine. Journal of Allergy and Clinical Immunology, 56: 215221.

B. Stenius and M. Lemola (1976) Hypersensitivity to acetylsalicylic acid (ASA) and tartrazine in patients with asthma. Clinical Allergy, 6: 119129.

A. Szczeklik , R. J. Gryglewski , and G. Czerniawska-Mysik (1975) Relationship of inhibition of prostaglandin biosynthesis by analgesics to asthma-attacks in aspirin-sensitive patients. British Medical Journal, 1: 6769.

A. Szczeklik , R. J. Gryglewski and G. Czerniawska-Mysik (1977) Clinical patterns of hypersensitivity to non-steroidal anti-inflammatory drugs and their pathogenesis. Journal of Allergy and Clinical Immunology 60: 276284.

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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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