Hostname: page-component-76fb5796d-qxdb6 Total loading time: 0 Render date: 2024-04-29T23:42:35.366Z Has data issue: false hasContentIssue false

A machine learning model for predicting the three-year survival status of patients with hypopharyngeal squamous cell carcinoma using multiple parameters

Published online by Cambridge University Press:  23 January 2023

Z Li*
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Beijing, China Department of Otorhinolaryngology – Head and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
S Ding
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Beijing, China
Q Zhong
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Beijing, China
J Fang
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Beijing, China
J Huang
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Beijing, China
Z Huang
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Beijing, China
Y Zhang
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Beijing, China
*
Corresponding author: Zufei Li, Department of Otorhinolaryngology - Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, 1, Dong Jiao Min Xiang Street, Dong Cheng District, Beijing 100730, PR China Email: 18710097558@163.com

Abstract

Objective

This study aimed to establish a model for predicting the three-year survival status of patients with hypopharyngeal squamous cell carcinoma using artificial intelligence algorithms.

Method

Data from 295 patients with hypopharyngeal squamous cell carcinoma were analysed retrospectively. Training sets comprised 70 per cent of the data and test sets the remaining 30 per cent. A total of 22 clinical parameters were included as training features. In total, 12 different types of machine learning algorithms were used for model construction. Accuracy, sensitivity, specificity, area under the receiver operating characteristic curve and Cohen's kappa co-efficient were used to evaluate model performance.

Results

The XGBoost algorithm achieved the best model performance. Accuracy, sensitivity, specificity, area under the receiver operating characteristic curve and kappa value of the model were 80.9 per cent, 92.6 per cent, 62.9 per cent, 77.7 per cent and 58.1 per cent, respectively.

Conclusion

This study successfully identified a machine learning model for predicting three-year survival status for patients with hypopharyngeal squamous cell carcinoma that can offer a new prognostic evaluation method for the clinical treatment of these patients.

Type
Main Article
Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Dr Y Zhang takes responsibility for the integrity of the content of the paper

References

Hall, SF, Groome, PA, Irish, J, O'Sullivan, B. The natural history of patients with squamous cell carcinoma of the hypopharynx. Laryngoscope 2008;118:1362–71CrossRefGoogle ScholarPubMed
Edge, SB, Compton, CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 2010;17:1471–4CrossRefGoogle ScholarPubMed
Garneau, JC, Bakst, RL, Miles, BA. Hypopharyngeal cancer: a state of the art review. Oral Oncol 2018;86:244–50CrossRefGoogle ScholarPubMed
Eckel, HE, Bradley, PJ. Treatment options for hypopharyngeal cancer. Adv Otorhinolaryngol 2019;83:4753Google ScholarPubMed
Lefebvre, JL, Chevalier, D, Luboinski, B, Kirkpatrick, A, Collette, L, Sahmoud, T. Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. EORTC Head and Neck Cancer Cooperative Group. J Natl Cancer Inst 1996;88:890–9CrossRefGoogle ScholarPubMed
Newman, JR, Connolly, TM, Illing, EA, Kilgore, ML, Locher, JL, Carroll, WR. Survival trends in hypopharyngeal cancer: a population-based review. Laryngoscope 2015;125:624–9CrossRefGoogle ScholarPubMed
Okada, Y, Mataga, I, Katagiri, M, Ishii, K. An analysis of cervical lymph nodes metastasis in oral squamous cell carcinoma. Relationship between grade of histopathological malignancy and lymph nodes metastasis. Int J Oral Maxillofac Surg 2003;32:284–8CrossRefGoogle ScholarPubMed
Howard, FM, Kochanny, S, Koshy, M, Spiotto, M, Pearson, AT. Machine learning-guided adjuvant treatment of head and neck cancer. JAMA Netw Open 2020;3:e2025881CrossRefGoogle ScholarPubMed
Smith, JB, Shew, M, Karadaghy, OA, Nallani, R, Sykes, KJ, Gan, GN et al. Predicting salvage laryngectomy in patients treated with primary nonsurgical therapy for laryngeal squamous cell carcinoma using machine learning. Head Neck 2020;42:2330–9CrossRefGoogle ScholarPubMed
Zhang, L, Wu, Y, Zheng, B, Su, L, Chen, Y, Ma, S et al. Rapid histology of laryngeal squamous cell carcinoma with deep-learning based stimulated Raman scattering microscopy. Theranostics 2019;9:2541–54CrossRefGoogle ScholarPubMed
Spicer, J, Sanborn, AN. What does the mind learn? A comparison of human and machine learning representations. Curr Opin Neurobiol 2019;55:97102CrossRefGoogle Scholar
Chen, T, Guestrin, C. Xgboost: a scalable tree boosting system. Proceedings of the 22nd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining. New York: Association for Computing Machinery, 2016:785–94CrossRefGoogle Scholar
Delen, D, Walker, G, Kadam, A. Predicting breast cancer survivability: a comparison of three data mining methods. Artif Intell Med 2005;34:113–27CrossRefGoogle ScholarPubMed
Gong, X, Zheng, B, Xu, G, Chen, H, Chen, C. Application of machine learning approaches to predict the 5-year survival status of patients with esophageal cancer. J Thorac Dis 2021;13:6240–51CrossRefGoogle ScholarPubMed
Lavieille, JP, Brambilla, E, Riva-Lavieille, C, Reyt, E, Charachon, R, Brambilla, C. Immunohistochemical detection of p53 protein in preneoplastic lesions and squamous cell carcinoma of the head and neck. Acta Otolaryngol 1995;115:334–9CrossRefGoogle ScholarPubMed
Dong, P, Sakata, K, Miyajima, Y, Chijiwa, K, Mori, K, Nakashima, T. The predictive value of p53, Ki-67 and angiogenetic factors in primary hypopharyngeal carcinoma. Kurume Med J 2001;48:261–6CrossRefGoogle ScholarPubMed
Wang, JX, Zhang, YY, Yu, XM, Jin, T, Pan, XL. Role of centromere protein H and Ki67 in relapse-free survival of patients after primary surgery for hypopharyngeal cancer. Asian Pac J Cancer Prev 2012;13:821–5CrossRefGoogle ScholarPubMed
Kılıç, S, Kılıç, SS, Hsueh, WD, Eloy, JA, Baredes, S, Woo Park, RC et al. Radiotherapy modality as a predictor of survival in hypopharyngeal cancer. Head Neck 2018;40:2441–8CrossRefGoogle ScholarPubMed
Wang, Y, Yue, C, Fang, J, Gong, L, Lian, M, Wang, R et al. Transcobalamin I: a novel prognostic biomarker of neoadjuvant chemotherapy in locally advanced hypopharyngeal squamous cell cancers. Onco Targets Ther 2018;11:4253–61CrossRefGoogle ScholarPubMed
Supplementary material: File

Li et al. supplementary material

Figure S1

Download Li et al. supplementary material(File)
File 50.7 KB