Article contents
Metronidazole ototoxicity - report of two cases
Published online by Cambridge University Press: 29 June 2007
Abstract
Two cases of bilateral moderate to severe sensorineural hearing loss due to oral administration of metronidazole are reported. There has been only one case report of deafness following metronidazole therapy in the world literature. The hearing loss recovered gradually in a period of four to six weeks following withdrawal of drug and oral steroid therapy. The possible mechanism of ototoxicity is discussed. Awareness by the treating physician of ototoxicity due to any drug is stressed.
- Type
- Clinical Records
- Information
- Copyright
- Copyright © JLO (1984) Limited 1999
References
Lawford, R., Sorrel, T. C. (1994) Amoebic abscess of the spleen complicated by metronidazole-induced neurotoxicity; case report. Clinics of Infectious Diseases 19(2): 246–248.Google Scholar
Quick, C. A. (1980) Chemical and drug effects on the inner ear. In Otolaryngology. 2nd Edition. vol. 2, (Paparella, M. M., Shumrick, D. A., eds.) W. B. Saunders, Philadelphia, pp 1804–1824.Google Scholar
Tracy, J. W., Webster, L. T. (1996) Drugs used in the chemotherapy of protozoal infections. In Goodman and Gilmans The Pharmacological Basis of Therapeutics. 9th Edition. (Hardman, J. G., Limbird, L. E., Molinoff, P. B., Ruddon, R. W., eds.) McGraw Hill, New York, pp 995–998.Google Scholar
- 13
- Cited by