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A moist edge environment aids the regeneration of traumatic tympanic membrane perforations

  • Z C Lou (a1) and Z H Lou (a2)

To review the history of moist therapy used to regenerate traumatic tympanic membrane perforations.

Study design:

Literature review.


The literature on topical agents used to treat traumatic tympanic membrane perforations was reviewed, and the advantages and disadvantages of moist therapy were analysed.


A total of 76 studies were included in the analysis. Topical applications of certain agents (e.g. growth factors, Ofloxacin Otic Solution, and insulin solutions) to the moist edges of traumatic tympanic membrane perforations shortened closure times and improved closure rates.


Dry tympanic membrane perforation edges may be associated with crust formation and centrifugal migration, delaying perforation closure. On the contrary, moist edges inhibit necrosis at the perforation margins, stimulate proliferation of granulation tissue and aid eardrum healing. Thus, moist perforation margins upon topical application of solutions of appropriate agents aid the regeneration of traumatic tympanic membrane perforations.

Corresponding author
Address for correspondence: Dr Zhengcai Lou, Department of Otorhinolaryngology, Affiliated Yiwu Hospital of Wenzhou Medical University, 699 Jiangdong Road, Yiwu, Zhejiang 322000, China Fax: +86 0579 520 9678 E-mail:
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