Skip to main content

Plasma levels of endothelial cell-specific molecule-1 and pentraxin-3 in idiopathic sudden sensorineural hearing loss

  • F Gündoğan (a1), A Bayram (a2), M Kalkan (a2) and İ Özcan (a2)

To evaluate the plasma levels of endothelial cell-specific molecule-1 (ESM-1) and pentraxin-3 (PTX-3) in patients with idiopathic sudden sensorineural hearing loss, and to compare the pre- and post-treatment levels in patients responsive and non-responsive to therapy.


The study included 108 subjects: 51 with idiopathic sudden sensorineural hearing loss and 57 controls. For ESM-1 and PTX-3 analyses, blood samples were collected before and three months after treatment initiation in the idiopathic sudden sensorineural hearing loss group and once for the control group. Treatment response was evaluated three months after therapy initiation with pure tone audiometry, and the patients were divided into two groups: responsive and non-responsive to treatment.


Serum ESM-1 levels were significantly higher in the idiopathic sudden sensorineural hearing loss group than the control group, whereas the difference was not significant for PTX-3. In the responsive and non-responsive groups, ESM-1 and PTX-3 levels were not statistically different before and after treatment.


To our knowledge, this is the first study investigating plasma ESM-1 and PTX-3 levels in idiopathic sudden sensorineural hearing loss. Increased plasma ESM-1 levels may confirm endothelial dysfunction involvement in idiopathic sudden sensorineural hearing loss pathogenesis, which could be associated with vascular impairment.

Corresponding author
Author for correspondence: Dr Ali Bayram, Kayseri Training and Research Hospital, Sanayi Mah. Atatürk Bulvarı Hastane Cad. No: 78, Kayseri 38010, Turkey E-mail: Fax: +90 352 3207313
Hide All

Dr A Bayram takes responsibility for the integrity of the content of the paper

Presented at the 39th Turkish National Congress of Otolaryngology Head and Neck Surgery, 8–12 November 2017, Antalya, Turkey.

Hide All
1Stachler, RJ, Chandrasekhar, SS, Archer, SM, Rosenfeld, RM, Schwartz, SR, Barrs, DM et al. Clinical practice guideline: sudden hearing loss. Otolaryngol Head Neck Surg 2012;146:135
2Byl, FM Jr. Sudden hearing loss: eight years’ experience and suggested prognostic table. Laryngoscope 1984;94:647–61
3Kuhn, M, Heman-Ackah, SE, Shaikh, JA, Roehm, PC. Sudden sensorineural hearing loss: a review of diagnosis, treatment, and prognosis. Trends Amplif 2011;15:91105
4Conlin, AE, Parnes, LS. Treatment of sudden sensorineural hearing loss: I. A systematic review. Arch Otolaryngol Head Neck Surg 2007;133:573–81
5Chau, JK, Lin, JR, Atashband, S, Irvine, RA, Westerberg, BD. Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss. Laryngoscope 2010;120:1011–21
6Mattox, DE, Simmons, FB. Natural history of sudden sensorineural hearing loss. Ann Otol Rhinol Laryngol 1977;86:463–80
7Quaranta, N, De Ceglie, V, D'Elia, A. Endothelial dysfunction in idiopathic sudden sensorineural hearing loss: a review. Audiol Res 2016;6:151
8Lassalle, P, Molet, S, Janin, A, Heyden, JV, Tavernier, J, Fiers, W et al. ESM-1 is a novel human endothelial cell-specific molecule expressed in lung and regulated by cytokines. J Biol Chem 1996;271:20458–64
9Yang, WE, Hsieh, MJ, Lin, CW, Kuo, CY, Yang, SF, Chuang, CY et al. Plasma levels of endothelial cell-specific molecule-1 as a potential biomarker of oral cancer progression. Int J Med Sci 2017;14:1094–100
10Balta, I, Balta, S, Koryurek, OM, Demirkol, S, Mikhailidis, DP, Celik, T et al. Serum endocan levels as a marker of disease activity in patients with Behçet disease. J Am Acad Dermatol 2014;70:291–6
11Balta, I, Balta, S, Demirkol, S, Mikhailidis, DP, Celik, T, Akhan, M et al. Elevated serum levels of endocan in patients with psoriasis vulgaris: correlations with cardiovascular risk and activity of disease. Br J Dermatol 2013;169:1066–70
12Yilmaz, MI, Siriopol, D, Saglam, M, Kurt, YG, Unal, HU, Eyileten, T et al. Plasma endocan levels associate with inflammation, vascular abnormalities, cardiovascular events, and survival in chronic kidney disease. Kidney Int 2014;86:1213–20
13Mantovani, A, Garlanda, C, Bottazzi, B, Peri, G, Doni, A, Martinez de la Torre, Y et al. The long pentraxin PTX3 in vascular pathology. Vascul Pharmacol 2006;45:326–30
14Yasunaga, T, Ikeda, S, Koga, S, Nakata, T, Yoshida, T, Masuda, N et al. Plasma pentraxin 3 is a more potent predictor of endothelial dysfunction than high-sensitive C-reactive protein. Int Heart J 2014;55:160–4
15Liu, S, Qu, X, Liu, F, Wang, C. Pentraxin 3 as a prognostic biomarker in patients with systemic inflammation or infection. Mediators Inflamm 2014;2014:421429
16World Health Organization. International Classification of Impairments, Disabilities and Handicaps. Geneva: World Health Organization, 1980;73
17Siegel, LG. The treatment of idiopathic sudden sensorineural hearing loss. Otolaryngol Clin North Am 1975;8:467–73
18Li, P, Zeng, XL, Ye, J, Yang, QT, Zhang, GH, Li, Y. Intratympanic methylprednisolone improves hearing function in refractory sudden sensorineural hearing loss: a control study. Audiol Neurootol 2011;16:198202
19Nakagawa, T, Yamamoto, M, Kumakawa, K, Usami, S, Hato, N, Tabuchi, K et al. Prognostic impact of salvage treatment on hearing recovery in patients with sudden sensorineural hearing loss refractory to systemic corticosteroids: a retrospective observational study. Auris Nasus Larynx 2016;43:489–94
20Dai, Y, Lu, L, Hou, J, Yang, X, Li, H, Yang, Y et al. Intratympanic methylprednisolone perfusion as a salvage treatment for profound idiopathic sudden sensorineural hearing loss. J Laryngol Otol 2017;131:404–10
21Pezzoli, M, Magnano, M, Maffi, L, Pezzoli, L, Marcato, P, Orione, M et al. Hyperbaric oxygen therapy as salvage treatment for sudden sensorineural hearing loss: a prospective controlled study. Eur Arch Otorhinolaryngol 2015;272:1659–66
22Quaranta, N, Ramunni, A, De Luca, C, Brescia, P, Dambra, P, De Tullio, G et al. Endothelial progenitor cells in sudden sensorineural hearing loss. Acta Otolaryngol 2011;131:347–50
23Capaccio, P, Pignataro, L, Gaini, LM, Sigismund, PE, Novembrino, C, De Giuseppe, R et al. Unbalanced oxidative status in idiopathic sudden sensorineural hearing loss. Eur Arch Otorhinolaryngol 2012;269:449–53
24Gul, F, Muderris, T, Yalciner, G, Sevil, E, Bercin, S, Ergin, M et al. A comprehensive study of oxidative stress in sudden hearing loss. Eur Arch Otorhinolaryngol 2017;274:1301–8
25Quaranta, N, Ramunni, A, Brescia, P, D'Elia, A, Vacca, A, Ria, R. Soluble intercellular adhesion molecule 1 and soluble vascular cell adhesion molecule 1 in sudden hearing loss. Otol Neurotol 2008;29:470–4
26Ciccone, MM, Cortese, F, Pinto, M, Di Teo, C, Fornarelli, F, Gesualdo, M et al. Endothelial function and cardiovascular risk in patients with idiopathic sudden sensorineural hearing loss. Atherosclerosis 2012;225:511–16
27Berjis, N, Moeinimehr, M, Hashemi, SM, Hashemi, SM, Bakhtiari, EK, Nasiri, S. Endothelial dysfunction in patients with sudden sensorineural hearing loss. Adv Biomed Res 2016;5:5
28Kanbay, A, Ceylan, E, İnönü Köseoğlu, H, Çalışkan, M, Takir, M, Tulu, S et al. Endocan: a novel predictor of endothelial dysfunction in obstructive sleep apnea syndrome. Clin Respir J 2018;12:8490
29Hamad, RR, Eriksson, MJ, Berg, E, Larsson, A, Bremme, K. Impaired endothelial function and elevated levels of pentraxin 3 in early-onset preeclampsia. Acta Obstet Gynecol Scand 2012;91:50–6
30Witasp, A, Ryden, M, Carrero, JJ, Qureshi, AR, Nordfors, L, Näslund, E et al. Elevated circulating levels and tissue expression of pentraxin 3 in uremia: a reflection of endothelial dysfunction. PLoS One 2013;8:e63493
31Tong, M, Carrero, JJ, Qureshi, AR, Anderstam, B, Heimbürger, O, Bárány, P et al. Plasma pentraxin 3 in patients with chronic kidney disease: associations with renal function, protein-energy wasting, cardiovascular disease, and mortality. Clin J Am Soc Nephrol 2007;2:889–97
32Suliman, ME, Yilmaz, MI, Carrero, JJ, Qureshi, AR, Saglam, M, Ipcioglu, OM et al. Novel links between the long pentraxin 3, endothelial dysfunction, and albuminuria in early and advanced chronic kidney disease. Clin J Am Soc Nephrol 2008;3:976–85
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *



Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed