Hostname: page-component-76fb5796d-r6qrq Total loading time: 0 Render date: 2024-04-27T19:25:22.908Z Has data issue: false hasContentIssue false

Rhinitis medicamentosa – comparing two treatment strategies: a retrospective analysis

Published online by Cambridge University Press:  05 February 2024

Itai Margulis*
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Lady Davis Carmel Medical Center and Ruth and Bruce Rappaport Faculty of Medicine, and Technion – Israel Institute of Technology, Haifa, Israel
Jenny Jrbashyan
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Lady Davis Carmel Medical Center and Ruth and Bruce Rappaport Faculty of Medicine, and Technion – Israel Institute of Technology, Haifa, Israel
Sivan Bitterman Fisher
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Lady Davis Carmel Medical Center and Ruth and Bruce Rappaport Faculty of Medicine, and Technion – Israel Institute of Technology, Haifa, Israel
Nir Feibish
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Lady Davis Carmel Medical Center and Ruth and Bruce Rappaport Faculty of Medicine, and Technion – Israel Institute of Technology, Haifa, Israel
Nili Stein
Affiliation:
Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel
Raanan Cohen-Kerem
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Lady Davis Carmel Medical Center and Ruth and Bruce Rappaport Faculty of Medicine, and Technion – Israel Institute of Technology, Haifa, Israel
*
Corresponding author: Itai Margulis; Email: itaimargulis@gmail.com

Abstract

Objective

Rhinitis medicamentosa poses a therapeutic challenge for both patients and physicians. Treatment strategies vary, starting with avoidance of decongestants, followed by medications or surgical intervention. This study aimed to compare two treatment strategies for this condition.

Methods

A review was conducted of patients diagnosed with rhinitis medicamentosa from 2013 to 2021, who were managed conservatively with medications or surgically by inferior turbinate reduction.

Results

Forty-seven patients were included: 21 patients were treated conservatively and 26 underwent turbinate reduction. Following surgical therapy, the frequency of using decongestants was significantly reduced (p < 0.001), with a significant improvement in Sino-Nasal Outcome Test-22 scores (p < 0.001). The conservative treatment group was significantly older with more co-morbidities. Following medical therapy, the conservative treatment group had a significant decrease in the frequency of decongestant use, but there was no significant improvement in their Sino-Nasal Outcome Test-22 scores.

Conclusion

Compared to conservative treatment, inferior turbinate reduction for rhinitis medicamentosa resulted in reduced decongestant use and improved quality of life.

Type
Main Article
Copyright
Copyright © The Author(s), 2024. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Itai Margulis takes responsibility for the integrity of the content of the paper

The paper was presented at the Israeli Rhinology Society annual meeting, 10 June 2022, Kfar Giladi, Israel.

References

Graf, P. Rhinitis medicamentosa: a review of causes and treatment. Treat Respir Med 2005;4:21–9CrossRefGoogle ScholarPubMed
Caffier, PP, Frieler, K, Scherer, H, Sedlmaier, B, Göktas, Ö. Rhinitis medicamentosa: therapeutic effect of diode laser inferior turbinate reduction on nasal obstruction and decongestant abuse. Am J Rhinol 2008;22:433–9CrossRefGoogle ScholarPubMed
Zucker, SM, Barton, BM, McCoul, ED. Management of rhinitis medicamentosa: a systematic review. Otolaryngol Head Neck Surg 2019;160:429–38CrossRefGoogle ScholarPubMed
Wallace, DV, Dykewicz, MS, Bernstein, DI, Blessing-Moore, J, Cox, L, Khan, DA et al. The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol 2008;122:184CrossRefGoogle ScholarPubMed
Shapira Galitz, Y, Halperin, D, Bavnik, Y, Warman, M. Sino-Nasal Outcome Test-22: translation, cross-cultural adaptation, and validation in Hebrew-speaking patients. Otolaryngol Head Neck Surg 2016;154:951–6CrossRefGoogle ScholarPubMed
Patel, A, Levi, JR, Brook, CD. Should excess topical decongestant use raise a red flag? Rhinitis medicamentosa and opioid use disorder. Ann Otol Rhinol Laryngol 2020;129:164–9CrossRefGoogle Scholar
De Corso, E, Mastrapasqua, RF, Tricarico, L, Settimi, S, Di Cesare, T, Mele, DA et al. Predisposing factors of rhinitis medicamentosa: what can influence drug discontinuation? Rhinology 2020;58:233–40Google ScholarPubMed
Li, LYJ, Wang, SY, Tsai, CY, Wu, CJ. Rhinitis medicamentosa. BMJ Case Rep 2021;14:e247051CrossRefGoogle ScholarPubMed
Neighbors, CL, Salvador, CF, Zhu, B, Camacho, M, Tsai, P. Intranasal corticosteroid and oxymetazoline for chronic rhinitis: a systematic review. J Laryngol Otol 2022;136:816CrossRefGoogle ScholarPubMed
Mortuaire, G, de Gabory, L, François, M, Massé, G, Bloch, F, Brion, N et al. Rebound congestion and rhinitis medicamentosa: nasal decongestants in clinical practice. Critical review of the literature by a medical panel. Eur Ann Otorhinolaryngol Head Neck Dis 2013;130:137–44CrossRefGoogle ScholarPubMed
Li, W, Misra, S, Harvey, RJ, Kalish, L. Long-term treatment outcomes in refractory rhinitis medicamentosa managed with nasal surgery. Int Forum Allergy Rhinol 2023;19. Epub 2023 Jul 14CrossRefGoogle Scholar
Hopkins, C, Gillett, S, Slack, R, Lund, VJ, Browne, JP. Psychometric validity of the 22-item Sinonasal Outcome Test. Clin Otolaryngol 2009;34:447–54CrossRefGoogle ScholarPubMed
Stewart, MG, Witsell, DL, Smith, TL, Weaver, EM, Yueh, B, Hannley, MT. Development and validation of the Nasal Obstruction Symptom Evaluation (NOSE) Scale. Otolaryngol Head Neck Surg 2004;130:157–63CrossRefGoogle ScholarPubMed
Fowler, J, Chin, CJ, Massoud, E. Rhinitis medicamentosa: a nationwide survey of Canadian otolaryngologists. J Otolaryngol Head Neck Surg 2019;48:70CrossRefGoogle ScholarPubMed
Vaidyanathan, S, Williamson, P, Clearie, K, Khan, F, Lipworth, B. Fluticasone reverses oxymetazoline-induced tachyphylaxis of response and rebound congestion. Am J Respir Crit Care Med 2010;182:1924CrossRefGoogle ScholarPubMed
Hallén, H, Enerdal, J, Graf, P. Fluticasone propionate nasal spray is more effective and has a faster onset of action than placebo in treatment of rhinitis medicamentosa. Clin Exp Allergy 1997;27:552–8CrossRefGoogle Scholar
Fokkens, WJ, Lund, VJ, Hopkins, C, Hellings, PW, Kern, R, Reitsma, S et al. Epos 2020. Off J Eur Int Rhinol Soc Confed Eur ORL-HNS 2020;Suppl 29:11Google Scholar
Menezes, AS, Guimarães, JR, Breda, M, Vieira, V, Dias, L. Septal and turbinate surgery: is overnight essential? Eur Arch Otorhinolaryngol 2018;275:131–8CrossRefGoogle ScholarPubMed
Bergmark, RW, Gray, ST. Surgical management of turbinate hypertrophy. Otolaryngol Clin North Am 2018;51:919–28CrossRefGoogle ScholarPubMed
Resende, L, Carmo, CD, Mocellin, L, Pasinato, R, Mocellin, M. Disease-specific quality of life after septoplasty and bilateral inferior turbinate outfracture in patients with nasal obstruction. Braz J Otorhinolaryngol 2018;84:591–8CrossRefGoogle ScholarPubMed
Orabi, AA, Sen, A, Timms, MS, Morar, P. Patient satisfaction survey of outpatient-based topical local anesthetic KTP laser inferior turbinectomy: a prospective study. Am J Rhinol 2007;21:198202CrossRefGoogle ScholarPubMed
Barham, HP, Thornton, MA, Knisely, A, Marcells, GN, Harvey, RJ, Sacks, R. Long-term outcomes in medial flap inferior turbinoplasty are superior to submucosal electrocautery and submucosal powered turbinate reduction. Int Forum Allergy Rhinol 2016;6:143–7CrossRefGoogle ScholarPubMed
Cam, B, Sari, M, Midi, A, Gergin, O. Xylitol treats nasal mucosa in rhinitis medicamentosa: an experimental rat model study. Eur Arch Otorhinolaryngol 2019;276:3123–30CrossRefGoogle ScholarPubMed
Casale, M, Vella, P, Moffa, A, Sabatino, L, Rinaldi, V, Grimaldi, V et al. Topical hyaluronic acid in rhinitis medicamentosa: could our perspective be changed? J Biol Regul Homeost Agents 2017;31:5562Google ScholarPubMed