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Rising incidence of head and neck mucosal melanoma in Australia

  • D Youssef (a1), S Vasani (a1), J Marquess (a2) and A Cervin (a1) (a3)
Abstract Objective:

To establish Australian population-based incidence trends for mucosal melanoma of the head and neck.


Cases between 1985 and 2009 were identified in the Australian Cancer Database. Age-standardised incidence trends were established, including subgroup stratification by sex and site.


A continuously progressive increase in incidence was evident in the 353 cases identified over the 25-year study period. This was particularly evident in sinonasal mucosal melanoma in men, despite the overall incidence remaining higher in women.


There is such paucity in published global incidence trends of head and neck mucosal melanoma. Comparisons of incidence patterns between countries can provide insight into aetiological factors of this rare disease.

Corresponding author
Address for correspondence: Dr Daniel Youssef, Department of Otolaryngology, Head and Neck Surgery, Royal Brisbane and Women's Hospital, Herston, Queensland 4006, Australia E-mail:
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Presented at the Australian Society of Head and Neck Surgery Annual Scientific Meeting, 7–9 March 2015, Sydney, Australia.

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1 EP Simard , EM Ward , R Siegel , A Jemal . Cancers with increasing incidence trends in the United States: 1999 through 2008. CA Cancer J Clin 2012;62:118–28

3 B Cagir , MH Whiteford , A Topham , J Rakinic , RD Fry . Changing epidemiology of anorectal melanoma. Dis Colon Rectum 1999;42:1203–8

4 TR Coté , LH Sobin . Primary melanomas of the esophagus and anorectum: epidemiologic comparison with melanoma of the skin. Melanoma Res 2009;19:5860

5 DM Marcus , RP Marcus , RS Prabhu , TK Owonikoko , DH Lawson , J Switchenko Rising incidence of mucosal melanoma of the head and neck in the United States. J Skin Cancer 2012;2012:231693

6 MA Weinstock . Malignant melanoma of the vulva and vagina in the United States: patterns of incidence and population-based estimates of survival. Am J Obstet Gynecol 1994;171:1225–30

7 BK Ragnarsson-Olding , PJ Nilsson , LB Olding , BR Nilsson . Primary ano-rectal malignant melanomas within a population-based national patient series in Sweden during 40 years. Acta Oncol 2009;48:125–31

8 CC McLaughlin , XC Wu , A Jemal , HJ Martin , LM Roche , VW Chen . Incidence of noncutaneous melanomas in the U.S. Cancer 2005;103:1000–7

9 B Ragnarsson-Olding , H Johansson , LE Rutqvist , U Ringborg . Malignant melanoma of the vulva and vagina. Trends in incidence, age distribution, and long-term survival among 245 consecutive cases in Sweden 1960–1984. Cancer 1993;71:1893–7

10 AE Chang , LH Karnell , HR Menck . The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer 1998;83:1664–78

11 NT Chiu , MA Weinstock . Melanoma of oronasal mucosa. Population-based analysis of occurrence and mortality. Arch Otolaryngol Head Neck Surg 1996;122:985–8

13 S Manolidis , PJ Donald . Malignant mucosal melanoma of the head and neck: review of the literature and report of 14 patients. Cancer 1997;80:1373–86

15 LD Thompson , JA Wieneke , M Miettinen . Sinonasal tract and nasopharyngeal melanomas: a clinicopathologic study of 115 cases with a proposed staging system. Am J Surg Pathol 2003;27:594611

16 AI Neugut , S Kizelnik-Freilich , C Ackerman . Black-white differences in risk for cutaneous, ocular, and visceral melanomas. Am J Public Health 1994;84:1828–9

18 JA Mackintosh . The antimicrobial properties of melanocytes, melanosomes and melanin and the evolution of black skin. J Theor Biol 2001;211:101–13

19 JL Maldonado , J Fridlyand , H Patel , AN Jain , K Busam , T Kageshita Determinants of BRAF mutations in primary melanomas. J Natl Cancer Inst 2003;95:1878–90

20 C Beadling , E Jacobson-Dunlop , FS Hodi , C Le , A Warrick , J Patterson KIT gene mutations and copy number in melanoma subtypes. Clin Cancer Res 2008;14:6821–8

21 JA Curtin , K Busam , D Pinkel , BC Bastian . Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol 2006;24:4340–6

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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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